| AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance T O'Hare, WC Shakespeare, X Zhu, CA Eide, VM Rivera, F Wang, ... Cancer cell 16 (5), 401-412, 2009 | 1430 | 2009 |
| Stapled α− helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy YS Chang, B Graves, V Guerlavais, C Tovar, K Packman, KH To, ... Proceedings of the National Academy of Sciences 110 (36), E3445-E3454, 2013 | 732 | 2013 |
| 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. TK Sawyer, PJ Sanfilippo, VJ Hruby, MH Engel, CB Heward, JB Burnett, ... Proceedings of the National Academy of Sciences 77 (10), 5754-5758, 1980 | 673 | 1980 |
| A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation TJ McQuade, AG Tomasselli, L Liu, V Karacostas, B Moss, TK Sawyer, ... Science 247 (4941), 454-456, 1990 | 510 | 1990 |
| Probing the α‐helical structural stability of stapled p53 peptides: molecular dynamics simulations and analysis Z Guo, U Mohanty, J Noehre, TK Sawyer, W Sherman, G Krilov Chemical biology & drug design 75 (4), 348-359, 2010 | 432 | 2010 |
| Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent … WS Huang, CA Metcalf, R Sundaramoorthi, Y Wang, D Zou, RM Thomas, ... Journal of medicinal chemistry 53 (12), 4701-4719, 2010 | 402 | 2010 |
| Substrate specificity of the protein tyrosine phosphatases. ZY Zhang, AM Thieme-Sefler, D Maclean, DJ McNamara, EM Dobrusin, ... Proceedings of the National Academy of Sciences 90 (10), 4446-4450, 1993 | 317 | 1993 |
| . alpha.-Melanotropin: the minimal active sequence in the frog skin bioassay VJ Hruby, BC Wilkes, ME Hadley, F Al-Obeidi, TK Sawyer, DJ Staples, ... Journal of medicinal chemistry 30 (11), 2126-2130, 1987 | 307 | 1987 |
| Structure at 2.5-. ANG. resolution of chemically synthesized Human Immunodeficiency Virus Type 1 protease complexed with a hydroxyethylene-based inhibitor M Jaskolski, AG Tomasselli, TK Sawyer, DG Staples, RL Heinrikson, ... Biochemistry 30 (6), 1600-1609, 1991 | 285 | 1991 |
| Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML T O'Hare, R Pollock, EP Stoffregen, JA Keats, OM Abdullah, EM Moseson, ... Blood 104 (8), 2532-2539, 2004 | 270 | 2004 |
| Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell … VG Brunton, E Avizienyte, VJ Fincham, B Serrels, CA Metcalf III, ... Cancer research 65 (4), 1335-1342, 2005 | 264 | 2005 |
| α-melanocyte stimulating hormone: a cyclic α-melanotropin exhibiting superagonist biological activity TK Sawyer, VJ Hruby, PS Darman, ME Hadley Proc. Natl. Acad. Sci. USA 79, 1751-1755, 1982 | 248* | 1982 |
| Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates ZY Zhang, D Maclean, DJ McNamara, TK Sawyer, JE Dixon Biochemistry 33 (8), 2285-2290, 1994 | 239 | 1994 |
| Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function NO Carragher, SM Walker, LA Scott Carragher, F Harris, TK Sawyer, ... Oncogene 25 (42), 5726-5740, 2006 | 215 | 2006 |
| The generation of molecular diversity MR Pavia, TK Sawyer, WH Moos Bioorganic & Medicinal Chemistry Letters 3 (3), 387-396, 1993 | 200 | 1993 |
| Src homology‐2 domains: Structure, mechanisms, and drug discovery TK Sawyer Peptide Science 47 (3), 243-261, 1998 | 186 | 1998 |
| Melanotropins: structural, conformational and biological considerations in the development of superpotent and superprolonged analogs VJ Hruby, BC Wilkes, WL Cody, TK Sawyer, ME Hadley Pept. Protein Rev 3 (1), 64, 1984 | 170 | 1984 |
| Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity W Shakespeare, M Yang, R Bohacek, F Cerasoli, K Stebbins, ... Proceedings of the National Academy of Sciences 97 (17), 9373-9378, 2000 | 167 | 2000 |
| Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases DP Lesslie, JM Summy, NU Parikh, F Fan, JG Trevino, TK Sawyer, ... British journal of cancer 94 (11), 1710-1717, 2006 | 166 | 2006 |
| A study of Src SH2 domain protein-phosphopeptide binding interactions by electrospray ionization mass spectrometry JA Loo, P Hu, P McConnell, WT Mueller, TK Sawyer, V Thanabal Journal of the American Society for Mass Spectrometry 8 (3), 234-243, 1997 | 164 | 1997 |
