Catalytic asymmetric reduction of difficult-to-reduce ketones: triple-code saturation mutagenesis of an alcohol dehydrogenase Z Sun, R Lonsdale, A Ilie, G Li, J Zhou, MT Reetz ACS Catalysis 6 (3), 1598-1605, 2016 | 125 | 2016 |
Can machine learning revolutionize directed evolution of selective enzymes? G Li, Y Dong, MT Reetz Advanced Synthesis & Catalysis 361 (11), 2377-2386, 2019 | 120 | 2019 |
Structure-guided triple-code saturation mutagenesis: efficient tuning of the stereoselectivity of an epoxide hydrolase Z Sun, R Lonsdale, L Wu, G Li, A Li, J Wang, J Zhou, MT Reetz ACS Catalysis 6 (3), 1590-1597, 2016 | 118 | 2016 |
A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes F Cadet, N Fontaine, G Li, J Sanchis, M Ng Fuk Chong, R Pandjaitan, ... Scientific reports 8 (1), 16757, 2018 | 113 | 2018 |
Biocatalysts for the pharmaceutical industry created by structure-guided directed evolution of stereoselective enzymes G Li, J Wang, MT Reetz Bioorganic & medicinal chemistry 26 (7), 1241-1251, 2018 | 107 | 2018 |
Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N G Li, P Yao, R Gong, J Li, P Liu, R Lonsdale, Q Wu, J Lin, D Zhu, ... Chemical Science 8 (5), 4093-4099, 2017 | 105 | 2017 |
Enzymatic site-selectivity enabled by structure-guided directed evolution J Wang, G Li, MT Reetz Chemical Communications 53 (28), 3916-3928, 2017 | 101 | 2017 |
Multiparameter optimization in directed evolution: engineering thermostability, enantioselectivity, and activity of an epoxide hydrolase G Li, H Zhang, Z Sun, X Liu, MT Reetz ACS Catalysis 6 (6), 3679-3687, 2016 | 68 | 2016 |
Deracemization of 2-methyl-1, 2, 3, 4-tetrahydroquinoline using mutant cyclohexylamine oxidase obtained by iterative saturation mutagenesis G Li, J Ren, P Yao, Y Duan, H Zhang, Q Wu, J Feng, PCK Lau, D Zhu ACS Catalysis 4 (3), 903-908, 2014 | 60 | 2014 |
Overriding traditional electronic effects in biocatalytic Baeyer–Villiger reactions by directed evolution G Li, M Garcia-Borràs, MJLJ Fürst, A Ilie, MW Fraaije, KN Houk, ... Journal of the American Chemical Society 140 (33), 10464-10472, 2018 | 57 | 2018 |
FoEG1, a secreted glycoside hydrolase family 12 protein from Fusarium oxysporum, triggers cell death and modulates plant immunity L Zhang, J Yan, Z Fu, W Shi, V Ninkuu, G Li, X Yang, H Zeng Molecular Plant Pathology 22 (5), 522-538, 2021 | 56 | 2021 |
Comparing different strategies in directed evolution of enzyme stereoselectivity: single‐versus double‐code saturation mutagenesis Z Sun, R Lonsdale, G Li, MT Reetz ChemBioChem 17 (19), 1865-1872, 2016 | 38 | 2016 |
Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution G Li, MA Maria-Solano, A Romero-Rivera, S Osuna, MT Reetz Chemical Communications 53 (68), 9454-9457, 2017 | 37 | 2017 |
Biocatalytic route to chiral 2-substituted-1, 2, 3, 4-tetrahydroquinolines using cyclohexylamine oxidase muteins P Yao, P Cong, R Gong, J Li, G Li, J Ren, J Feng, J Lin, PCK Lau, Q Wu, ... ACS Catalysis 8 (3), 1648-1652, 2018 | 33 | 2018 |
Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution G Li, MJLJ Fürst, HR Mansouri, AK Ressmann, A Ilie, F Rudroff, ... Organic & Biomolecular Chemistry 15 (46), 9824-9829, 2017 | 31 | 2017 |
Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines G Li, J Ren, H Iwaki, D Zhang, Y Hasegawa, Q Wu, J Feng, PCK Lau, ... Applied microbiology and biotechnology 98, 1681-1689, 2014 | 30 | 2014 |
Machine learning enables selection of epistatic enzyme mutants for stability against unfolding and detrimental aggregation G Li, Y Qin, NT Fontaine, M Ng Fuk Chong, MA Maria‐Solano, F Feixas, ... ChemBioChem 22 (5), 904-914, 2021 | 27 | 2021 |
International Health Informatics Study (IHIS) Network G Tse, M Gong, CW Wong, C Chan, S Georgopoulos, YS Chan, BP Yan, ... Ann. Noninvasive Electrocardiol 23, e12495, 2018 | 27 | 2018 |
Ethylene‐responsive factor ERF114 mediates fungal pathogen effector PevD1‐induced disease resistance in Arabidopsis thaliana Z Li, Y Zhang, J Ren, F Jia, H Zeng, G Li, X Yang Molecular Plant Pathology 23 (6), 819-831, 2022 | 25 | 2022 |
Exploring the substrate scope of mutants derived from the robust alcohol dehydrogenase TbSADH Z Sun, G Li, A Ilie, MT Reetz Tetrahedron Letters 57 (32), 3648-3651, 2016 | 23 | 2016 |