Structural basis for the modulation of voltage-gated sodium channels by animal toxins H Shen, Z Li, Y Jiang, X Pan, J Wu, B Cristofori-Armstrong, JJ Smith, ... Science 362 (6412), eaau2596, 2018 | 236 | 2018 |
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a IR Chassagnon, CA McCarthy, YKY Chin, SS Pineda, A Keramidas, ... Proceedings of the National Academy of Sciences 114 (14), 3750-3755, 2017 | 205 | 2017 |
Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities M Chandra, YKY Chin, C Mas, JR Feathers, B Paul, S Datta, KE Chen, ... Nature communications 10 (1), 1528, 2019 | 131 | 2019 |
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes JJ Paxman, NA Borg, J Horne, PE Thompson, Y Chin, P Sharma, ... Journal of biological chemistry 284 (26), 17835-17845, 2009 | 83 | 2009 |
Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene SS Pineda, YKY Chin, EAB Undheim, S Senff, M Mobli, C Dauly, ... Proceedings of the National Academy of Sciences 117 (21), 11399-11408, 2020 | 77 | 2020 |
PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold B Madio, S Peigneur, YKY Chin, BR Hamilton, ST Henriques, JJ Smith, ... Cellular and molecular life sciences 75, 4511-4524, 2018 | 45 | 2018 |
Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1. 7 JK Klint, YKY Chin, M Mobli Molecular Pharmacology 88 (6), 1002-1010, 2015 | 33 | 2015 |
The structure of integrin α1I domain in complex with a collagen-mimetic peptide YKY Chin, SJ Headey, B Mohanty, R Patil, PA McEwan, JD Swarbrick, ... Journal of Biological Chemistry 288 (52), 36796-36809, 2013 | 32 | 2013 |
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis JP Vivian, J Scoullar, AL Robertson, SP Bottomley, J Horne, Y Chin, ... Journal of Biological Chemistry 283 (47), 32452-32461, 2008 | 29 | 2008 |
A selective NaV1. 1 activator with potential for treatment of Dravet syndrome epilepsy CY Chow, YKY Chin, L Ma, EAB Undheim, V Herzig, GF King Biochemical pharmacology 181, 113991, 2020 | 28 | 2020 |
Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae—a 15N-1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA J Horne, EJ d’Auvergne, M Coles, T Velkov, Y Chin, WN Charman, ... Journal of molecular biology 371 (3), 703-716, 2007 | 27 | 2007 |
Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus A Touchard, A Brust, FC Cardoso, YKY Chin, V Herzig, AH Jin, A Dejean, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1860 (11), 2553-2562, 2016 | 24 | 2016 |
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity JS Wingerd, CA Mozar, CA Ussing, SS Murali, YKY Chin, ... Scientific reports 7 (1), 974, 2017 | 21 | 2017 |
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals DA Eagles, NJ Saez, B Krishnarjuna, JJ Bradford, YKY Chin, H Starobova, ... Proceedings of the National Academy of Sciences 119 (7), e2112630119, 2022 | 19 | 2022 |
Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs CY Chow, YKY Chin, AA Walker, S Guo, LV Blomster, MJ Ward, V Herzig, ... ACS Pharmacology & Translational Science 3 (1), 119-134, 2019 | 17 | 2019 |
Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider RK Finol-Urdaneta, R Ziegman, Z Dekan, JR McArthur, S Heitmann, ... Proceedings of the National Academy of Sciences 119 (5), e2110932119, 2022 | 15 | 2022 |
The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides E Deplazes, YKY Chin, GF King, RL Mancera Proteins: Structure, Function, and Bioinformatics 88 (3), 485-502, 2020 | 15 | 2020 |
Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target L Ma, YKY Chin, Z Dekan, V Herzig, CY Chow, J Heighway, SW Lam, ... Biochemical pharmacology 158, 60-72, 2018 | 15 | 2018 |
Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides V Herzig, AD De Araujo, KP Greenwood, YKY Chin, MJ Windley, Y Chong, ... Biomedicines 6 (3), 90, 2018 | 15 | 2018 |
Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom K Luna-Ramirez, A Csoti, JR McArthur, YKY Chin, R Anangi, ... Biochemical Pharmacology 174, 113782, 2020 | 12 | 2020 |