EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis European Association for the Study of the Liver Journal of hepatology 63 (1), 237-264, 2015 | 986 | 2015 |
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 S Adler, D Basketter, S Creton, O Pelkonen, J Van Benthem, V Zuang, ... Archives of toxicology 85, 367-485, 2011 | 639 | 2011 |
The Hippo pathway effector YAP controls mouse hepatic stellate cell activation I Mannaerts, SB Leite, S Verhulst, S Claerhout, N Eysackers, LFR Thoen, ... Journal of hepatology 63 (3), 679-688, 2015 | 355 | 2015 |
Human liver cell spheroids in extended perfusion bioreactor culture for repeated‐dose drug testing RM Tostões, SB Leite, M Serra, J Jensen, P Björquist, MJT Carrondo, ... Hepatology 55 (4), 1227-1236, 2012 | 264 | 2012 |
Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro SB Leite, T Roosens, A El Taghdouini, I Mannaerts, AJ Smout, M Najimi, ... Biomaterials 78, 1-10, 2016 | 232 | 2016 |
Generation of hepatic stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis M Coll, L Perea, R Boon, SB Leite, J Vallverdú, I Mannaerts, A Smout, ... Cell stem cell 23 (1), 101-113. e7, 2018 | 205 | 2018 |
Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches S Coecke, O Pelkonen, SB Leite, U Bernauer, JGM Bessems, FY Bois, ... Toxicology in vitro 27 (5), 1570-1577, 2013 | 159 | 2013 |
PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA–EURL ECVAM ADME workshop JG Bessems, G Loizou, K Krishnan, HJ Clewell III, C Bernasconi, F Bois, ... Regulatory Toxicology and Pharmacology 68 (1), 119-139, 2014 | 147 | 2014 |
Extending hepatocyte functionality for drug-testing applications using high-viscosity alginate–encapsulated three-dimensional cultures in bioreactors JP Miranda, A Rodrigues, RM Tostoes, S Leite, H Zimmerman, ... Tissue Engineering Part C: Methods 16 (6), 1223-1232, 2010 | 123 | 2010 |
Three-dimensional HepaRG model as an attractive tool for toxicity testing SB Leite, I Wilk-Zasadna, JM Zaldivar, E Airola, MA Reis-Fernandes, ... Toxicological sciences 130 (1), 106-116, 2012 | 111 | 2012 |
Perfusion of 3D encapsulated hepatocytes—A synergistic effect enhancing long‐term functionality in bioreactors RM Tostões, SB Leite, JP Miranda, M Sousa, DIC Wang, MJT Carrondo, ... Biotechnology and bioengineering 108 (1), 41-49, 2011 | 107 | 2011 |
Towards an Extended Functional Hepatocyte In Vitro Culture JP Miranda, SB Leite, U Muller-Vieira, A Rodrigues, MJT Carrondo, ... Tissue Engineering Part C: Methods 15 (2), 157-167, 2009 | 100 | 2009 |
Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods E Berggren, A White, G Ouedraogo, A Paini, AN Richarz, FY Bois, T Exner, ... Computational Toxicology 4, 31-44, 2017 | 90 | 2017 |
Standardisation needs for organ on chip devices M Piergiovanni, SB Leite, R Corvi, M Whelan Lab on a Chip 21 (15), 2857-2868, 2021 | 72 | 2021 |
Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data A Krebs, T Waldmann, MF Wilks, BMA van Vugt-Lussenburg, ... ALTEX-Alternatives to animal experimentation 36 (4), 682-699, 2019 | 65 | 2019 |
Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications SB Leite, AP Teixeira, JP Miranda, RM Tostões, JJ Clemente, MF Sousa, ... Toxicology in Vitro 25 (4), 825-832, 2011 | 64 | 2011 |
Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology JA Harrill, MR Viant, CL Yauk, M Sachana, TW Gant, SS Auerbach, ... Regulatory Toxicology and Pharmacology 125, 105020, 2021 | 58 | 2021 |
Stirred bioreactors for the expansion of adult pancreatic stem cells M Serra, C Brito, SB Leite, E Gorjup, H von Briesen, MJT Carrondo, ... Annals of Anatomy-Anatomischer Anzeiger 191 (1), 104-115, 2009 | 42 | 2009 |
Novel culture strategy for human stem cell proliferation and neuronal differentiation M Serra, SB Leite, C Brito, J Costa, MJT Carrondo, PM Alves Journal of neuroscience research 85 (16), 3557-3566, 2007 | 36 | 2007 |
Unfolded protein response is an early, non-critical event during hepatic stellate cell activation I Mannaerts, LFR Thoen, N Eysackers, FJ Cubero, S Batista Leite, ... Cell Death & Disease 10 (2), 98, 2019 | 33 | 2019 |