| Folding-unfolding transitions in single titin molecules characterized with laser tweezers MSZ Kellermayer, SB Smith, HL Granzier, C Bustamante Science 276 (5315), 1112-1116, 1997 | 1472 | 1997 |
| The complete gene sequence of titin, expression of an unusual≈ 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system ML Bang, T Centner, F Fornoff, AJ Geach, M Gotthardt, M McNabb, ... Circulation research 89 (11), 1065-1072, 2001 | 825 | 2001 |
| The giant protein titin: a major player in myocardial mechanics, signaling, and disease HL Granzier, S Labeit Circulation research 94 (3), 284-295, 2004 | 749 | 2004 |
| Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments HL Granzier, TC Irving Biophysical journal 68 (3), 1027-1044, 1995 | 740 | 1995 |
| Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy B Gerull, M Gramlich, J Atherton, M McNabb, K Trombitás, ... Nature genetics 30 (2), 201-204, 2002 | 718 | 2002 |
| Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin MR Zile, CF Baicu, J S. Ikonomidis, RE Stroud, PJ Nietert, AD Bradshaw, ... Circulation 131 (14), 1247-1259, 2015 | 689 | 2015 |
| Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy SF Nagueh, G Shah, Y Wu, G Torre-Amione, NMP King, S Lahmers, ... Circulation 110 (2), 155-162, 2004 | 575 | 2004 |
| Differential expression of cardiac titin isoforms and modulation of cellular stiffness O Cazorla, A Freiburg, M Helmes, T Centner, M McNabb, Y Wu, ... Circulation research 86 (1), 59-67, 2000 | 513 | 2000 |
| Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain T Centner, J Yano, E Kimura, AS McElhinny, K Pelin, CC Witt, ML Bang, ... Journal of molecular biology 306 (4), 717-726, 2001 | 482 | 2001 |
| Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity A Freiburg, K Trombitas, W Hell, O Cazorla, F Fougerousse, T Centner, ... Circulation research 86 (11), 1114-1121, 2000 | 448 | 2000 |
| Muscle assembly: a titanic achievement? CC Gregorio, H Granzier, H Sorimachi, S Labeit Current opinion in cell biology 11 (1), 18-25, 1999 | 440 | 1999 |
| Calcium-dependent molecular spring elements in the giant protein titin D Labeit, K Watanabe, C Witt, H Fujita, Y Wu, S Lahmers, T Funck, ... Proceedings of the National Academy of Sciences 100 (23), 13716-13721, 2003 | 439 | 2003 |
| Right ventricular diastolic impairment in patients with pulmonary arterial hypertension S Rain, ML Handoko, P Trip, CTJ Gan, N Westerhof, GJ Stienen, ... Circulation 128 (18), 2016-2025, 2013 | 402 | 2013 |
| The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules MK Miller, ML Bang, CC Witt, D Labeit, C Trombitas, K Watanabe, ... Journal of molecular biology 333 (5), 951-964, 2003 | 400 | 2003 |
| Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium S Lahmers, Y Wu, DR Call, S Labeit, H Granzier Circulation research 94 (4), 505-513, 2004 | 394 | 2004 |
| The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity CC Gregorio, K Trombitás, T Centner, B Kolmerer, G Stier, K Kunke, ... The Journal of cell biology 143 (4), 1013, 1998 | 394 | 1998 |
| Protein kinase A phosphorylates titin’s cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes R Yamasaki, Y Wu, M McNabb, M Greaser, S Labeit, H Granzier Circulation research 90 (11), 1181-1188, 2002 | 368 | 2002 |
| MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination SH Witt, H Granzier, CC Witt, S Labeit Journal of molecular biology 350 (4), 713-722, 2005 | 361 | 2005 |
| Research priorities for heart failure with preserved ejection fraction: national heart, lung, and blood institute working group summary SJ Shah, BA Borlaug, DW Kitzman, AD McCulloch, BC Blaxall, R Agarwal, ... Circulation 141 (12), 1001-1026, 2020 | 352 | 2020 |
| Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy–overlap syndromes M Taylor, S Graw, G Sinagra, C Barnes, D Slavov, F Brun, B Pinamonti, ... Circulation 124 (8), 876-885, 2011 | 350 | 2011 |
