Transcriptional regulatory networks underlying gene expression changes in Huntington's disease SA Ament, JR Pearl, JP Cantle, RM Bragg, PJ Skene, SR Coffey, ... Molecular systems biology 14 (3), e7435, 2018 | 70 | 2018 |
Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations S Malaiya, M Cortes-Gutierrez, BR Herb, SR Coffey, SRW Legg, ... Journal of Neuroscience 41 (25), 5534-5552, 2021 | 43 | 2021 |
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease RM Bragg, SR Coffey, RM Weston, SA Ament, JP Cantle, S Minnig, ... Scientific reports 7 (1), 41570, 2017 | 22 | 2017 |
Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease SR Coffey, RM Bragg, S Minnig, SA Ament, JP Cantle, A Glickenhaus, ... PloS one 12 (4), e0175968, 2017 | 14 | 2017 |
Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools S Minnig, RM Bragg, HS Tiwana, WT Solem, WS Hovander, EMS Vik, ... Scientific Reports 8 (1), 2304, 2018 | 7 | 2018 |
Huntingtin lowering reduces somatic instability at CAG-expanded loci SR Coffey, M Andrew, H Ging, J Hamilton, M Flower, M Kovalenko, ... bioRxiv, 2020.07. 23.218347, 2020 | 5 | 2020 |
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease JR Pearl, AC Shetty, JP Cantle, DE Bergey, RM Bragg, SR Coffey, ... bioRxiv, 2020.06. 04.132571, 2020 | 4 | 2020 |
Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation RM Bragg, SR Coffey, JP Cantle, S Hu, S Singh, SRW Legg, CA McHugh, ... Life Science Alliance 6 (11), 2023 | 3 | 2023 |
Stool is a sensitive and noninvasive source of DNA for monitoring expansion in repeat expansion disease mouse models X Zhao, C McHugh, SR Coffey, DA Jimenez, E Adams, JB Carroll, K Usdin Disease Models & Mechanisms 15 (5), dmm049453, 2022 | 2 | 2022 |
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6. Htt RM Bragg, SR Coffey, RM Weston, SA Ament, JP Cantle | | |