| Hot spots for allosteric regulation on protein surfaces KA Reynolds, RN McLaughlin, R Ranganathan Cell 147 (7), 1564-1575, 2011 | 380 | 2011 |
| Evolution-based functional decomposition of proteins O Rivoire, KA Reynolds, R Ranganathan PLoS computational biology 12 (6), e1004817, 2016 | 152 | 2016 |
| Analysis of full and partial agonists binding to β2‐adrenergic receptor suggests a role of transmembrane helix V in agonist‐specific conformational changes V Katritch, KA Reynolds, V Cherezov, MA Hanson, CB Roth, M Yeager, ... Journal of Molecular Recognition 22 (4), 307-318, 2009 | 146 | 2009 |
| An evolutionary hotspot defines functional differences between CRYPTOCHROMES C Rosensweig, KA Reynolds, P Gao, I Laothamatas, Y Shan, ... Nature communications 9 (1), 1138, 2018 | 89 | 2018 |
| Identifying conformational changes of the β 2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators KA Reynolds, V Katritch, R Abagyan Journal of computer-aided molecular design 23 (5), 273-288, 2009 | 73 | 2009 |
| Structural and Computational Characterization of the SHV-1 β-Lactamase-β-Lactamase inhibitor protein interface KA Reynolds, JM Thomson, KD Corbett, CR Bethel, JM Berger, JF Kirsch, ... Journal of Biological Chemistry 281 (36), 26745-26753, 2006 | 70 | 2006 |
| High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection YT Tamer, IK Gaszek, H Abdizadeh, TA Batur, KA Reynolds, AR Atilgan, ... Molecular biology and evolution 36 (7), 1533-1550, 2019 | 64 | 2019 |
| Evolution-based design of proteins KA Reynolds, WP Russ, M Socolich, R Ranganathan Methods in enzymology 523, 213-235, 2013 | 56 | 2013 |
| Computational redesign of the SHV-1 β-lactamase/β-lactamase inhibitor protein interface KA Reynolds, MS Hanes, JM Thomson, AJ Antczak, JM Berger, ... Journal of molecular biology 382 (5), 1265-1275, 2008 | 53 | 2008 |
| An object‐oriented library for computational protein design AB Chowdry, KA Reynolds, MS Hanes, M Voorhies, N Pokala, TM Handel Journal of computational chemistry 28 (14), 2378-2388, 2007 | 48 | 2007 |
| Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme S Thompson, Y Zhang, C Ingle, KA Reynolds, T Kortemme Elife 9, e53476, 2020 | 41 | 2020 |
| Cloning and Characterization of the Dictyostelium discoideum cycloartenol synthase cDNA. SM Godzina, MA Lovato, M M.M, KA Foster, WK Wilson, W Gu, ... Lipids 36, 249-255, 2000 | 36 | 2000 |
| Structurally distributed surface sites tune allosteric regulation JW McCormick, MAX Russo, S Thompson, A Blevins, KA Reynolds Elife 10, e68346, 2021 | 29 | 2021 |
| A two-enzyme adaptive unit within bacterial folate metabolism AF Schober, AD Mathis, C Ingle, JO Park, L Chen, JD Rabinowitz, I Junier, ... Cell reports 27 (11), 3359-3370. e7, 2019 | 29 | 2019 |
| Evolution and engineering of allosteric regulation in protein kinases D Pincus, JP Pandey, ZA Feder, P Creixell, O Resnekov, KA Reynolds Science signaling 11 (555), 2018 | 29 | 2018 |
| Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily C Narayanan, D Gagné, KA Reynolds, N Doucet Scientific reports 7 (1), 3207, 2017 | 24 | 2017 |
| Strategies for Engineering and Rewiring Kinase Regulation JW McCormick, D Pincus, O Resnekov, KA Reynolds Trends in biochemical sciences 45 (3), 259-271, 2020 | 20 | 2020 |
| Specificity and cooperativity at β‐lactamase position 104 in TEM‐1/BLIP and SHV‐1/BLIP interactions MS Hanes, KA Reynolds, C McNamara, P Ghosh, RA Bonomo, JF Kirsch, ... Proteins: Structure, Function, and Bioinformatics 79 (4), 1267-1276, 2011 | 18 | 2011 |
| A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth AD Mathis, RM Otto, KA Reynolds Nucleic Acids Research 49 (1), e6-e6, 2021 | 17 | 2021 |
| An evolution-based strategy for engineering allosteric regulation D Pincus, O Resnekov, KA Reynolds Physical biology 14 (2), 025002, 2017 | 16 | 2017 |
Rama RanganathanProfessor, Biochemistry and Molecular Biology, Institute for Molecular Engineering在 uchicago.edu 的电子邮件经过验证
