| IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway DF Lee, HP Kuo, CT Chen, JM Hsu, CK Chou, Y Wei, HL Sun, LY Li, ... Cell 130 (3), 440-455, 2007 | 821 | 2007 |
| ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation JY Yang, CS Zong, W Xia, H Yamaguchi, Q Ding, X Xie, JY Lang, CC Lai, ... Nature cell biology 10 (2), 138-148, 2008 | 800 | 2008 |
| Survival of cancer cells is maintained by EGFR independent of its kinase activity Z Weihua, R Tsan, WC Huang, Q Wu, CH Chiu, IJ Fidler, MC Hung Cancer cell 13 (5), 385-393, 2008 | 582 | 2008 |
| Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and … CC Chen, MP Chow, WC Huang, YC Lin, YJ Chang Molecular pharmacology 66 (3), 683-693, 2004 | 330 | 2004 |
| Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity WC Huang, CC Chen Molecular and cellular biology 25 (15), 6592-6602, 2005 | 309 | 2005 |
| Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB WC Huang, TK Ju, MC Hung, CC Chen Molecular cell 26 (1), 75-87, 2007 | 306 | 2007 |
| Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells WC Huang, YJ Chen, LY Li, YL Wei, SC Hsu, SL Tsai, PC Chiu, ... Journal of Biological Chemistry 286 (23), 20558-20568, 2011 | 207 | 2011 |
| P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts C Dou, Z Liu, K Tu, H Zhang, C Chen, U Yaqoob, Y Wang, J Wen, ... Gastroenterology 154 (8), 2209-2221. e14, 2018 | 173 | 2018 |
| c-Src-dependent tyrosine phosphorylation of IKKβ is involved in tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression WC Huang, JJ Chen, CC Chen Journal of Biological Chemistry 278 (11), 9944-9952, 2003 | 166 | 2003 |
| Induction of Akt activity by chemotherapy confers acquired resistance WC Huang, MC Hung Journal of the Formosan Medical Association 108 (3), 180-194, 2009 | 163 | 2009 |
| Tyrosine phosphorylation of I-κB kinase α/β by protein kinase C-dependent c-Src activation is involved in TNF-α-induced cyclooxygenase-2 expression WC Huang, JJ Chen, H Inoue, CC Chen The Journal of Immunology 170 (9), 4767-4775, 2003 | 152* | 2003 |
| Beyond NF-κB activation: nuclear functions of IκB kinase α WC Huang, MC Hung Journal of biomedical science 20, 1-13, 2013 | 131 | 2013 |
| Tumor necrosis factor α-induced activation of downstream NF-κB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion: involvement of PKCα, tyrosine … CC Chen, CY Chou, YT Sun, WC Huang Cellular Signalling 13 (8), 543-553, 2001 | 127 | 2001 |
| HDAC inhibition decreases the expression of EGFR in colorectal cancer cells CW Chou, MS Wu, WC Huang, CC Chen PloS one 6 (3), e18087, 2011 | 124 | 2011 |
| Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel α-methylene-γ-butyrolactone … WC Huang, ST Chan, TL Yang, CC Tzeng, CC Chen Carcinogenesis 25 (10), 1925-1934, 2004 | 120 | 2004 |
| Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT … JJ Chen, WC Huang, CC Chen Molecular biology of the cell 16 (12), 5579-5591, 2005 | 105 | 2005 |
| Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells YJ Chen, WC Huang, YL Wei, SC Hsu, P Yuan, HY Lin, II Wistuba, JJ Lee, ... PloS one 6 (6), e21428, 2011 | 103 | 2011 |
| miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway SL Tung, WC Huang, FC Hsu, ZP Yang, TH Jang, JW Chang, CM Chuang, ... Oncogenesis 6 (5), e326-e326, 2017 | 95 | 2017 |
| Hesperidin is a potential inhibitor against SARS-CoV-2 infection FJ Cheng, TK Huynh, CS Yang, DW Hu, YC Shen, CY Tu, YC Wu, ... Nutrients 13 (8), 2800, 2021 | 93 | 2021 |
| BCRP/ABCG2 inhibition sensitizes hepatocellular carcinoma cells to sorafenib WC Huang, YL Hsieh, CM Hung, PH Chien, YF Chien, LC Chen, CY Tu, ... PLoS one 8 (12), e83627, 2013 | 88 | 2013 |
