Succinate is an inflammatory signal that induces IL-1β through HIF-1α GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, ... Nature 496 (7444), 238-242, 2013 | 3551 | 2013 |
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages EM Palsson-McDermott, AM Curtis, G Goel, MAR Lauterbach, FJ Sheedy, ... Cell metabolism 21 (1), 65-80, 2015 | 1165 | 2015 |
Nondegradative role of Atg5-Atg12/Atg16L1 autophagy protein complex in antiviral activity of interferon gamma S Hwang, NS Maloney, MW Bruinsma, G Goel, E Duan, L Zhang, ... Cell host & microbe 11 (4), 397-409, 2012 | 283 | 2012 |
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection KL Conway, P Kuballa, JH Song, KK Patel, AB Castoreno, OH Yilmaz, ... Gastroenterology 145 (6), 1347-1357, 2013 | 268 | 2013 |
Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis M Beaudoin, P Goyette, G Boucher, KS Lo, MA Rivas, C Stevens, ... PLoS genetics 9 (9), e1003723, 2013 | 227 | 2013 |
Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter TA Reese, BS Wakeman, HS Choi, MM Hufford, SC Huang, X Zhang, ... Science 345 (6196), 573-577, 2014 | 220 | 2014 |
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies G Goel, T King, AJ Daveson, JM Andrews, J Krishnarajah, R Krause, ... The lancet Gastroenterology & hepatology 2 (7), 479-493, 2017 | 165 | 2017 |
Mechanisms of pediatric inflammatory bowel disease JM Peloquin, G Goel, EJ Villablanca, RJ Xavier Annual review of immunology 34 (1), 31-64, 2016 | 127 | 2016 |
Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk KG Lassen, CI McKenzie, M Mari, T Murano, J Begun, LA Baxt, G Goel, ... Immunity 44 (6), 1392-1405, 2016 | 124 | 2016 |
Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease G Goel, JA Tye-Din, SW Qiao, AK Russell, T Mayassi, C Ciszewski, ... Science advances 5 (8), eaaw7756, 2019 | 112 | 2019 |
System estimation from metabolic time-series data G Goel, IC Chou, EO Voit Bioinformatics 24 (21), 2505-2511, 2008 | 102 | 2008 |
RNF166 determines recruitment of adaptor proteins during antibacterial autophagy RJ Heath, G Goel, LA Baxt, JS Rush, V Mohanan, GLC Paulus, V Jani, ... Cell reports 17 (9), 2183-2194, 2016 | 96 | 2016 |
Regulation of glycolysis in Lactococcus lactis: an unfinished systems biological case study EO Voit, J Almeida, S Marino, R Lall, G Goel, AR Neves, H Santos IEE Proceedings-Systems Biology 153 (4), 286-298, 2006 | 96 | 2006 |
Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer EM Coffee, AC Faber, J Roper, MJ Sinnamon, G Goel, L Keung, ... Clinical cancer research 19 (10), 2688-2698, 2013 | 92 | 2013 |
Essential cell-autonomous role for interferon (IFN) regulatory factor 1 in IFN-γ-mediated inhibition of norovirus replication in macrophages NS Maloney, LB Thackray, G Goel, S Hwang, E Duan, P Vachharajani, ... Journal of virology 86 (23), 12655-12664, 2012 | 74 | 2012 |
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics SY Kuo, AB Castoreno, LN Aldrich, KG Lassen, G Goel, V Dančík, ... Proceedings of the National Academy of Sciences 112 (31), E4281-E4287, 2015 | 71 | 2015 |
Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks C Zhou, AEH Elia, ML Naylor, N Dephoure, BA Ballif, G Goel, Q Xu, A Ng, ... Proceedings of the national academy of sciences 113 (26), E3667-E3675, 2016 | 66 | 2016 |
Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules SY Shaw, K Tran, AB Castoreno, JM Peloquin, KG Lassen, B Khor, ... ACS chemical biology 8 (12), 2724-2733, 2013 | 65 | 2013 |
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells B Khor, JD Gagnon, G Goel, MI Roche, KL Conway, K Tran, LN Aldrich, ... Elife 4, e05920, 2015 | 64 | 2015 |
A systems biology viewpoint on autophagy in health and disease A Huett, G Goel, RJ Xavier Current opinion in gastroenterology 26 (4), 302-309, 2010 | 64 | 2010 |