| Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps KW Chen, M Monteleone, D Boucher, G Sollberger, D Ramnath, ... Science immunology 3 (26), eaar6676, 2018 | 507 | 2018 |
| Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, ... Journal of Experimental Medicine 215 (3), 827-840, 2018 | 489 | 2018 |
| The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge KW Chen, CJ Groß, FV Sotomayor, KJ Stacey, J Tschopp, MJ Sweet, ... Cell reports 8 (2), 570-582, 2014 | 425 | 2014 |
| Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ... Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017 | 403 | 2017 |
| Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly KW Chen, B Demarco, R Heilig, K Shkarina, A Boettcher, CJ Farady, ... The EMBO journal 38 (10), e101638, 2019 | 330 | 2019 |
| Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion M Monteleone, AC Stanley, KW Chen, DL Brown, JS Bezbradica, ... Cell reports 24 (6), 1425-1433, 2018 | 285 | 2018 |
| Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria JC Santos, D Boucher, LK Schneider, B Demarco, M Dilucca, K Shkarina, ... Nature communications 11 (1), 3276, 2020 | 217 | 2020 |
| Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality B Demarco, JP Grayczyk, E Bjanes, D Le Roy, W Tonnus, ... Science advances 6 (47), eabc3465, 2020 | 161 | 2020 |
| XIAP loss triggers RIPK3-and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation KE Lawlor, R Feltham, M Yabal, SA Conos, KW Chen, S Ziehe, C Graß, ... Cell reports 20 (3), 668-682, 2017 | 133 | 2017 |
| Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling L Luo, AA Wall, JC Yeo, ND Condon, SJ Norwood, S Schoenwaelder, ... Nature communications 5 (1), 4407, 2014 | 128 | 2014 |
| A novel flow cytometric method to assess inflammasome formation DP Sester, SJ Thygesen, V Sagulenko, PR Vajjhala, JA Cridland, N Vitak, ... The Journal of Immunology 194 (1), 455-462, 2015 | 110 | 2015 |
| RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling KW Chen, B Demarco, S Ramos, R Heilig, M Goris, JP Grayczyk, ... Proceedings of the National Academy of Sciences 118 (28), e2101189118, 2021 | 86 | 2021 |
| Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis KW Chen, B Demarco, P Broz The EMBO journal 39 (2), e103397, 2020 | 82 | 2020 |
| Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD R Heilig, M Dilucca, D Boucher, KW Chen, D Hancz, B Demarco, ... Life science alliance 3 (6), 2020 | 78 | 2020 |
| Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or Non‐canonical inflammasome activation KW Chen, B Demarco, P Broz European journal of immunology, 2019 | 74 | 2019 |
| ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome KS Robinson, GA Toh, P Rozario, R Chua, S Bauernfried, Z Sun, ... Science 377 (6603), 328-335, 2022 | 73 | 2022 |
| An antioxidant role for catecholate siderophores in Salmonella MES Achard, KW Chen, MJ Sweet, RE Watts, K Schroder, MA Schembri, ... Biochemical Journal 454 (3), 543-549, 2013 | 68 | 2013 |
| Antimicrobial functions of inflammasomes KW Chen, K Schroder Current opinion in microbiology 16 (3), 311-318, 2013 | 55 | 2013 |
| Posttranslational and therapeutic control of gasdermin-mediated pyroptosis and inflammation FA Fischer, KW Chen, JS Bezbradica Frontiers in immunology 12, 661162, 2021 | 52 | 2021 |
| Cross talk between intracellular pathogens and cell death B Demarco, KW Chen, P Broz Immunological reviews 297 (1), 174-193, 2020 | 50 | 2020 |
