Fundamental properties of unperturbed haematopoiesis from stem cells in vivo K Busch, K Klapproth, M Barile, M Flossdorf, T Holland-Letz, ... Nature 518 (7540), 542-546, 2015 | 778 | 2015 |
Disparate individual fates compose robust CD8+ T cell immunity VR Buchholz, M Flossdorf, I Hensel, L Kretschmer, B Weissbrich, P Gräf, ... Science 340 (6132), 630-635, 2013 | 454 | 2013 |
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes AB Stittrich, C Haftmann, E Sgouroudis, AA Kühl, AN Hegazy, I Panse, ... Nature immunology 11 (11), 1057-1062, 2010 | 390 | 2010 |
Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8+ central memory T cells P Graef, VR Buchholz, C Stemberger, M Flossdorf, L Henkel, ... Immunity 41 (1), 116-126, 2014 | 358 | 2014 |
Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments D Busse, M de la Rosa, K Hobiger, K Thurley, M Flossdorf, A Scheffold, ... Proceedings of the National Academy of Sciences 107 (7), 3058-3063, 2010 | 320 | 2010 |
Multi‐layered stochasticity and paracrine signal propagation shape the type‐I interferon response U Rand, M Rinas, J Schwerk, G Nöhren, M Linnes, A Kröger, M Flossdorf, ... Molecular systems biology 8 (1), 584, 2012 | 178 | 2012 |
Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma I Poschke, M Faryna, F Bergmann, M Flossdorf, C Lauenstein, J Hermes, ... OncoImmunology 5 (12), e1240859, 2016 | 91 | 2016 |
Differential expansion of T central memory precursor and effector subsets is regulated by division speed L Kretschmer, M Flossdorf, J Mir, YL Cho, M Plambeck, I Treise, A Toska, ... Nature Communications 11 (1), 1-12, 2020 | 71 | 2020 |
TCR Signal Quality Modulates Fate Decisions of Single CD4+ T Cells in a Probabilistic Manner YL Cho, M Flossdorf, L Kretschmer, T Höfer, DH Busch, VR Buchholz Cell Reports 20 (4), 806-818, 2017 | 67 | 2017 |
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment C Falcomatà, S Bärthel, SA Widholz, C Schneeweis, JJ Montero, A Toska, ... Nature Cancer, 1-19, 2022 | 59 | 2022 |
Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant B Schmid, M Rinas, A Ruggieri, EG Acosta, M Bartenschlager, A Reuter, ... PLoS Pathog 11 (12), e1005345, 2015 | 59 | 2015 |
Distinct surface expression of activating receptor Ly49H drives differential expansion of NK cell clones upon murine cytomegalovirus infection S Grassmann, LO Pachmayr, J Leube, L Mihatsch, I Andrae, ... Immunity 50 (6), 1391-1400. e4, 2019 | 57 | 2019 |
Individual T Helper Cells Have a Quantitative Cytokine Memory C Helmstetter, M Flossdorf, M Peine, A Kupz, J Zhu, AN Hegazy, ... Immunity 42 (1), 108-122, 2015 | 56 | 2015 |
The outcome of ex vivo TIL expansion is highly influenced by spatial heterogeneity of the tumor T-cell repertoire and differences in intrinsic in vitro growth capacity between … IC Poschke, JC Hassel, A Rodriguez-Ehrenfried, KAM Lindner, ... Clinical Cancer Research 26 (16), 4289-4301, 2020 | 55 | 2020 |
CD8+ T cell diversification by asymmetric cell division M Flossdorf, J Rössler, VR Buchholz, DH Busch, T Höfer Nature immunology 16 (9), 891, 2015 | 53 | 2015 |
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection S Flommersfeld, JP Böttcher, J Ersching, M Flossdorf, P Meiser, ... Immunity 54 (10), 2288-2304. e7, 2021 | 49 | 2021 |
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection S Grassmann, L Mihatsch, J Mir, A Kazeroonian, R Rahimi, ... Nature Immunology 21 (12), 1563-1573, 2020 | 45 | 2020 |
Antihypertensive drugs in COVID-19 infection SJ Pinto-Sietsma, M Flossdorf, VR Buchholz, J Offerhaus, H Bleijendaal, ... European Heart Journal-Cardiovascular Pharmacotherapy 6 (6), 415-416, 2020 | 35 | 2020 |
Hypercharge-universal topcolor F Braam, M Flossdorf, RS Chivukula, S Di Chiara, EH Simmons Physical Review D 77 (5), 055005, 2008 | 31 | 2008 |
Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling S Bortoluzzi, N Dashtsoodol, T Engleitner, C Drees, S Helmrath, J Mir, ... Immunity 54 (11), 2497-2513. e9, 2021 | 25 | 2021 |