Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2258 | 2019 |
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature PT Nelson, I Alafuzoff, EH Bigio, C Bouras, H Braak, NJ Cairns, ... Journal of Neuropathology & Experimental Neurology 71 (5), 362-381, 2012 | 2175 | 2012 |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ... Nature genetics 43 (5), 436-441, 2011 | 2158 | 2011 |
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease MJ West, PD Coleman, DG Flood, JC Troncoso The lancet 344 (8925), 769-772, 1994 | 1598 | 1994 |
Primary age-related tauopathy (PART): a common pathology associated with human aging JF Crary, JQ Trojanowski, JA Schneider, JF Abisambra, EL Abner, ... Acta neuropathologica 128, 755-766, 2014 | 1356 | 2014 |
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity FC Nucifora Jr, M Sasaki, MF Peters, H Huang, JK Cooper, M Yamada, ... Science 291 (5512), 2423-2428, 2001 | 1317 | 2001 |
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease RG Cutler, J Kelly, K Storie, WA Pedersen, A Tammara, K Hatanpaa, ... Proceedings of the National Academy of Sciences 101 (7), 2070-2075, 2004 | 1268 | 2004 |
C9orf72 nucleotide repeat structures initiate molecular cascades of disease AR Haeusler, CJ Donnelly, G Periz, EAJ Simko, PG Shaw, MS Kim, ... Nature 507 (7491), 195-200, 2014 | 1016 | 2014 |
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations AM Cataldo, CM Peterhoff, JC Troncoso, T Gomez-Isla, BT Hyman, ... The American journal of pathology 157 (1), 277-286, 2000 | 935 | 2000 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 919 | 2017 |
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain JR Gibbs, MP Van Der Brug, DG Hernandez, BJ Traynor, MA Nalls, SL Lai, ... PLoS genetics 6 (5), e1000952, 2010 | 901 | 2010 |
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function KKK Chung, B Thomas, X Li, O Pletnikova, JC Troncoso, L Marsh, ... Science 304 (5675), 1328-1331, 2004 | 885 | 2004 |
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia T Zu, Y Liu, M Bañez-Coronel, T Reid, O Pletnikova, J Lewis, TM Miller, ... Proceedings of the National Academy of Sciences 110 (51), E4968-E4977, 2013 | 857 | 2013 |
Common genetic variants influence human subcortical brain structures DP Hibar, JL Stein, ME Renteria, A Arias-Vasquez, S Desrivières, ... Nature 520 (7546), 224-229, 2015 | 845 | 2015 |
Genetic variability in the regulation of gene expression in ten regions of the human brain A Ramasamy, D Trabzuni, S Guelfi, V Varghese, C Smith, R Walker, T De, ... Nature neuroscience 17 (10), 1418-1428, 2014 | 685 | 2014 |
Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease CI Sze, JC Troncoso, C Kawas, P Mouton, DL Price, LJ Martin Journal of Neuropathology & Experimental Neurology 56 (8), 933-944, 1997 | 679 | 1997 |
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, ... Nature medicine 26 (5), 769-780, 2020 | 669 | 2020 |
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy GU Höglinger, NM Melhem, DW Dickson, PMA Sleiman, LS Wang, L Klei, ... Nature genetics 43 (7), 699-705, 2011 | 625 | 2011 |
Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions S Engelender, Z Kaminsky, X Guo, AH Sharp, RK Amaravi, JJ Kleiderlein, ... Nature genetics 22 (1), 110-114, 1999 | 625 | 1999 |
Gene expression changes in the course of normal brain aging are sexually dimorphic NC Berchtold, DH Cribbs, PD Coleman, J Rogers, E Head, R Kim, ... Proceedings of the National Academy of Sciences 105 (40), 15605-15610, 2008 | 622 | 2008 |