| Chromatin-level regulation of biosynthetic gene clusters JW Bok, YM Chiang, E Szewczyk, Y Reyes-Dominguez, AD Davidson, ... Nature chemical biology 5 (7), 462-464, 2009 | 445 | 2009 |
| Oxidative cyclization in natural product biosynthesis MC Tang, Y Zou, K Watanabe, CT Walsh, Y Tang Chemical Reviews 117 (8), 5226-5333, 2017 | 335 | 2017 |
| Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli K Watanabe, K Hotta, AP Praseuth, K Koketsu, A Migita, CN Boddy, ... Nature chemical biology 2 (8), 423-428, 2006 | 281 | 2006 |
| Insight into a natural Diels–Alder reaction from the structure of macrophomate synthase T Ose, K Watanabe, T Mie, M Honma, H Watanabe, M Yao, H Oikawa, ... Nature 422 (6928), 185-189, 2003 | 261 | 2003 |
| Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway YM Chiang, E Szewczyk, T Nayak, AD Davidson, JF Sanchez, HC Lo, ... Chemistry & biology 15 (6), 527-532, 2008 | 228 | 2008 |
| Biosynthesis of lovastatin analogs with a broadly specific acyltransferase X Xie, K Watanabe, WA Wojcicki, CCC Wang, Y Tang Chemistry & biology 13 (11), 1161-1169, 2006 | 194 | 2006 |
| SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis M Ohashi, F Liu, Y Hai, M Chen, M Tang, Z Yang, M Sato, K Watanabe, ... Nature 549 (7673), 502-506, 2017 | 179 | 2017 |
| Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk Y Tsunematsu, N Ishikawa, D Wakana, Y Goda, H Noguchi, H Moriya, ... Nature Chemical Biology 9 (12), 818-825, 2013 | 143 | 2013 |
| Detailed reaction mechanism of macrophomate synthase: extraordinary enzyme catalyzing five-step transformation from 2-pyrones to benzoates K Watanabe, T Mie, A Ichihara, H Oikawa, M Honma Journal of Biological Chemistry 275 (49), 38393-38401, 2000 | 124 | 2000 |
| Non‐Heme Dioxygenase Catalyzes Atypical Oxidations of 6, 7‐Bicyclic Systems To Form the 6, 6‐Quinolone Core of Viridicatin‐Type Fungal Alkaloids N Ishikawa, H Tanaka, F Koyama, H Noguchi, CCC Wang, K Hotta, ... Angewandte Chemie International Edition 53 (47), 12880-12884, 2014 | 123 | 2014 |
| Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms K Koketsu, K Watanabe, H Suda, H Oguri, H Oikawa Nature chemical biology 6 (6), 408-410, 2010 | 120 | 2010 |
| Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis K Hotta, X Chen, RS Paton, A Minami, H Li, K Swaminathan, II Mathews, ... Nature 483 (7389), 355-358, 2012 | 116 | 2012 |
| Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis K Ishiuchi, T Nakazawa, F Yagishita, T Mino, H Noguchi, K Hotta, ... Journal of the American Chemical Society 135 (19), 7371-7377, 2013 | 112 | 2013 |
| Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway HC Lin, Y Tsunematsu, S Dhingra, W Xu, M Fukutomi, YH Chooi, ... Journal of the American Chemical Society 136 (11), 4426-4436, 2014 | 111 | 2014 |
| Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli K Watanabe, MA Rude, CT Walsh, C Khosla Proceedings of the National Academy of Sciences 100 (17), 9774-9778, 2003 | 111 | 2003 |
| Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575 LB Pickens, W Kim, P Wang, H Zhou, K Watanabe, S Gomi, Y Tang Journal of the American Chemical Society 131 (48), 17677-17689, 2009 | 106 | 2009 |
| Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide … JM Winter, M Sato, S Sugimoto, G Chiou, NK Garg, Y Tang, K Watanabe Journal of the American Chemical Society 134 (43), 17900-17903, 2012 | 104 | 2012 |
| A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae H Zhou, J Zhan, K Watanabe, X Xie, Y Tang Proceedings of the National Academy of Sciences 105 (17), 6249-6254, 2008 | 104 | 2008 |
| Biochemical characterization of a eukaryotic decalin-forming Diels–Alderase L Li, P Yu, MC Tang, Y Zou, SS Gao, YS Hung, M Zhao, K Watanabe, ... Journal of the American Chemical Society 138 (49), 15837-15840, 2016 | 100 | 2016 |
| Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis Y Shichijo, A Migita, H Oguri, M Watanabe, T Tokiwano, K Watanabe, ... Journal of the American Chemical Society 130 (37), 12230-12231, 2008 | 95 | 2008 |
