| RNA-guided genetic silencing systems in bacteria and archaea B Wiedenheft, SH Sternberg, JA Doudna Nature 482 (7385), 331-338, 2012 | 2665 | 2012 |
| DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 SH Sternberg, S Redding, M Jinek, EC Greene, JA Doudna Biophysical Journal 106 (2), 695a, 2014 | 2349 | 2014 |
| Structures of Cas9 endonucleases reveal RNA-mediated conformational activation M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ... Science 343 (6176), 1247997, 2014 | 1555 | 2014 |
| Enhanced proofreading governs CRISPR–Cas9 targeting accuracy JS Chen, YS Dagdas, BP Kleinstiver, MM Welch, AA Sousa, ... Nature 550 (7676), 407-410, 2017 | 1164 | 2017 |
| A prudent path forward for genomic engineering and germline gene modification D Baltimore, P Berg, M Botchan, D Carroll, RA Charo, G Church, JE Corn, ... Science 348 (6230), 36-38, 2015 | 945 | 2015 |
| Programmable RNA recognition and cleavage by CRISPR/Cas9 MR O’Connell, BL Oakes, SH Sternberg, A East-Seletsky, M Kaplan, ... Nature 516 (7530), 263-266, 2014 | 758 | 2014 |
| Conformational control of DNA target cleavage by CRISPR–Cas9 SH Sternberg, B LaFrance, M Kaplan, JA Doudna Nature 527 (7576), 110-113, 2015 | 665 | 2015 |
| Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration SE Klompe, PLH Vo, TS Halpin-Healy, SH Sternberg Nature 571 (7764), 219-225, 2019 | 534 | 2019 |
| Expanding the biologist’s toolkit with CRISPR-Cas9 SH Sternberg, JA Doudna Molecular cell 58 (4), 568-574, 2015 | 505 | 2015 |
| Rational design of a split-Cas9 enzyme complex AV Wright, SH Sternberg, DW Taylor, BT Staahl, JA Bardales, JE Kornfeld, ... Proceedings of the National Academy of Sciences 112 (10), 2984-2989, 2015 | 380 | 2015 |
| Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9 D Singh, SH Sternberg, J Fei, JA Doudna, T Ha Nature communications 7 (1), 12778, 2016 | 272 | 2016 |
| Adaptation in CRISPR-Cas systems SH Sternberg, H Richter, E Charpentier, U Qimron Molecular cell 61 (6), 797-808, 2016 | 272 | 2016 |
| CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference ML Hochstrasser, DW Taylor, P Bhat, CK Guegler, SH Sternberg, ... Proceedings of the National Academy of Sciences 111 (18), 6618-6623, 2014 | 269 | 2014 |
| A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9 YS Dagdas, JS Chen, SH Sternberg, JA Doudna, A Yildiz Science advances 3 (8), eaao0027, 2017 | 261 | 2017 |
| CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering PLH Vo, C Ronda, SE Klompe, EE Chen, C Acree, HH Wang, ... Nature biotechnology 39 (4), 480-489, 2021 | 238 | 2021 |
| Surveillance and processing of foreign DNA by the Escherichia coli CRISPR-Cas system S Redding, SH Sternberg, M Marshall, B Gibb, P Bhat, CK Guegler, ... Cell 163 (4), 854-865, 2015 | 232 | 2015 |
| High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding EA Boyle, JOL Andreasson, LM Chircus, SH Sternberg, MJ Wu, ... Proceedings of the National Academy of Sciences 114 (21), 5461-5466, 2017 | 206 | 2017 |
| Mechanism of substrate selection by a highly specific CRISPR endoribonuclease SH Sternberg, RE Haurwitz, JA Doudna Rna 18 (4), 661-672, 2012 | 200 | 2012 |
| Substrate-specific kinetics of Dicer-catalyzed RNA processing S Chakravarthy, SH Sternberg, CA Kellenberger, JA Doudna Journal of molecular biology 404 (3), 392-402, 2010 | 184 | 2010 |
| Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA RE Haurwitz, SH Sternberg, JA Doudna The EMBO journal 31 (12), 2824-2832, 2012 | 131 | 2012 |
