Molecular mechanisms of glucocorticoid action: what is important? R Newton Thorax 55 (7), 603-613, 2000 | 736 | 2000 |
Evidence for involvement of NF-κB in the transcriptional control of COX-2 gene expression by IL-1β R Newton, LME Kuitert, M Bergmann, IM Adcock, PJ Barnes Biochemical and biophysical research communications 237 (1), 28-32, 1997 | 500 | 1997 |
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms LE Donnelly, R Newton, GE Kennedy, PS Fenwick, RHF Leung, K Ito, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 287 (4 …, 2004 | 499 | 2004 |
Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? R Newton, NS Holden Molecular pharmacology 72 (4), 799-809, 2007 | 401 | 2007 |
Human labour is associated with nuclear factor-κB activity which mediates cyclo-oxygenase-2 expression and is involved with the ‘functional progesterone withdrawal’ VC Allport, D Pieber, DM Slater, R Newton, JO White, PR Bennett Molecular Human Reproduction 7 (6), 581-586, 2001 | 375 | 2001 |
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2 MA Giembycz, CJ Corrigan, J Seybold, R Newton, PJ Barnes British journal of pharmacology 118 (8), 1945-1958, 1996 | 257 | 1996 |
TGFβ1 allele association with asthma severity LJ Pulleyn, R Newton, IM Adcock, PJ Barnes Human genetics 109, 623-627, 2001 | 248 | 2001 |
Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA R Newton, J Seybold, LME Kuitert, M Bergmann, PJ Barnes Journal of Biological Chemistry 273 (48), 32312-32321, 1998 | 244 | 1998 |
IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription REQUIREMENT FOR AN … M Bergmann, L Hart, M Lindsay, PJ Barnes, R Newton Journal of Biological Chemistry 273 (12), 6607-6610, 1998 | 226* | 1998 |
Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term DM Slater, LC Berger, R Newton, GE Moore, PR Bennett American journal of obstetrics and gynecology 172 (1), 77-82, 1995 | 221 | 1995 |
Discovery of BRL 50481 [3-(N, N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages … SJ Smith, LB Cieslinski, R Newton, LE Donnelly, PS Fenwick, ... Molecular pharmacology 66 (6), 1679-1689, 2004 | 207* | 2004 |
Expression of RANTES mRNA and protein in airways of patients with mild asthma. N Berkman, VL Krishnan, T Gilbey, R Newton, B O'Connor, PJ Barnes, ... American journal of respiratory and critical care medicine 154 (6), 1804-1811, 1996 | 202 | 1996 |
Beyond the dogma: novel β2-adrenoceptor signalling in the airways MA Giembycz, R Newton European Respiratory Journal 27 (6), 1286-1306, 2006 | 201 | 2006 |
Cytokine induction of cytosolic phospholipase A 2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells R Newton, LM Kuitert, DM Slater, IM Adcock, PJ Barnes Life sciences 60 (1), 67-78, 1996 | 195 | 1996 |
Long-acting β2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells M Kaur, JE Chivers, MA Giembycz, R Newton Molecular pharmacology 73 (1), 203-214, 2008 | 193 | 2008 |
Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells EVIDENCE FOR ADDITIONAL REGULATORY STEPS IN … Y Nasuhara, IM Adcock, M Catley, PJ Barnes, R Newton Journal of Biological Chemistry 274 (28), 19965-19972, 1999 | 186* | 1999 |
Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling R Leigh, W Oyelusi, S Wiehler, R Koetzler, RS Zaheer, R Newton, ... Journal of Allergy and Clinical Immunology 121 (5), 1238-1245. e4, 2008 | 183 | 2008 |
Iκ-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma MA Birrell, E Hardaker, S Wong, K McCluskie, M Catley, J De Alba, ... American journal of respiratory and critical care medicine 172 (8), 962-971, 2005 | 178 | 2005 |
NF-κB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH) VC Allport, DM Slater, R Newton, PR Bennett Molecular Human Reproduction 6 (6), 561-565, 2000 | 168 | 2000 |
Inhibition of NF-κB-dependent Transcription by MKP-1 TRANSCRIPTIONAL REPRESSION BY GLUCOCORTICOIDS OCCURRING VIA p38 MAPK EM King, NS Holden, W Gong, CF Rider, R Newton Journal of Biological Chemistry 284 (39), 26803-26815, 2009 | 163 | 2009 |