Structures of human pannexin 1 reveal ion pathways and mechanism of gating Z Ruan, IJ Orozco, J Du, W Lü Nature 584 (7822), 646–651, 2020 | 154 | 2020 |
Cerebellar ataxia and coenzyme Q deficiency through loss of unorthodox kinase activity JA Stefely, F Licitra, L Laredj, AG Reidenbach, ZA Kemmerer, ... Molecular cell 63 (4), 608-620, 2016 | 116 | 2016 |
STRAW: species TRee analysis web server TI Shaw, Z Ruan, TC Glenn, L Liu Nucleic acids research 41 (W1), W238-W241, 2013 | 113 | 2013 |
Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations Z Ruan, N Kannan Proceedings of the National Academy of Sciences of USA 115 (35), E8162-E8171, 2018 | 62 | 2018 |
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1 SA Jamieson*, Z Ruan*, AE Burgess, JR Curry, HD McMillan, JL Brewster, ... Science Signaling 11 (549), eaau0597, 2018 | 61 | 2018 |
Structures and pH-sensing mechanism of the proton-activated chloride channel Z Ruan*, J Osei-Owusu*, J Du, Z Qiu, W Lü Nature 588 (7837), 350–354, 2020 | 48 | 2020 |
Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis J Osei-Owusu, J Yang, KH Leung, Z Ruan, W Lü, Y Krishnan, Z Qiu Cell reports 34 (4), 2021 | 42 | 2021 |
Hydrophobic core variations provide a structural framework for tyrosine kinase evolution and functional specialization S Mohanty, K Oruganty, A Kwon, DP Byrne, S Ferries, Z Ruan, LE Hanold, ... PLoS genetics 12 (2), e1005885, 2016 | 39 | 2016 |
Mechanistic insights into R776H mediated activation of epidermal growth factor receptor kinase Z Ruan, N Kannan Biochemistry 54 (27), 4216-4225, 2015 | 38 | 2015 |
Structures of TRPM5 channel elucidate mechanism of activation and inhibition Z Ruan*, E Haley*, I Orozco*, R Roth, M Sabat, R Myers, J Du, W Lü Nature Structural & Molecular Biology, 2021 | 35 | 2021 |
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources LC Huang, KE Ross, TR Baffi, H Drabkin, KJ Kochut, Z Ruan, ... Scientific Reports 8, 6518, 2018 | 33 | 2018 |
LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena YY Jiang, W Maier, R Baumeister, G Minevich, E Joachimiak, D Wloga, ... PLoS Genetics 15 (7), 2019 | 24 | 2019 |
The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena YY Jiang, W Maier, R Baumeister, G Minevich, E Joachimiak, Z Ruan, ... Genetics 206 (2), 873-888, 2017 | 23 | 2017 |
Emerging roles of the αC‐β4 loop in protein kinase structure, function, evolution, and disease W Yeung*, Z Ruan*, N Kannan IUBMB Life 72 (6), 1189-1202, 2020 | 22 | 2020 |
Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail T Nguyen, Z Ruan, K Oruganty, N Kannan PLoS One 10 (3), e0119636, 2015 | 22 | 2015 |
Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation MD Fulton, LE Hanold, Z Ruan, S Patel, AM Beedle, N Kannan, ... Bioorganic & Medicinal Chemistry 26 (6), 1167-1173, 2018 | 21 | 2018 |
Computational and experimental characterization of patient derived mutations reveal an unusual mode of regulatory spine assembly and drug sensitivity in EGFR kinase Z Ruan, S Katiyar, N Kannan Biochemistry 56 (1), 22-32, 2017 | 20 | 2017 |
Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of Ephrin tyrosine kinase evolution A Kwon, M John, Z Ruan, N Kannan Journal of Biological Chemistry 293 (14), 5102-5116, 2018 | 19 | 2018 |
Extensive non-canonical phosphorylation in human cells revealed using strong-anion exchange-mediated phosphoproteomics G Hardman, S Perkins, Z Ruan, N Kannan, P Brownridge, DP Byrne, ... bioRxiv, 2017 | 19 | 2017 |
Molecular determinants of pH sensing in the proton-activated chloride channel J Osei-Owusu, E Kots, Z Ruan, L Mihaljević, KH Chen, A Tamhaney, X Ye, ... Proceedings of the National Academy of Sciences of USA 119 (31), e2200727119, 2022 | 17 | 2022 |