The animal trypanosomiases and their chemotherapy: a review F Giordani, LJ Morrison, TG Rowan, HP De Koning, MP Barrett Parasitology 143 (14), 1862-1889, 2016 | 428 | 2016 |
Drugs and drug resistance in African trypanosomiasis V Delespaux, HP de Koning Drug resistance updates 10 (1-2), 30-50, 2007 | 361 | 2007 |
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future PG Bray, MP Barrett, SA Ward, HP de Koning Trends in parasitology 19 (5), 232-239, 2003 | 326 | 2003 |
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story N Baker, HP de Koning, P Mäser, D Horn Trends in parasitology 29 (3), 110-118, 2013 | 311 | 2013 |
Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei E Matovu, ML Stewart, F Geiser, R Brun, P Mäser, LJM Wallace, ... Eukaryotic Cell 2 (5), 1003-1008, 2003 | 247 | 2003 |
Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy HP De Koning, DJ Bridges, RJS Burchmore FEMS microbiology reviews 29 (5), 987-1020, 2005 | 226 | 2005 |
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species C Changtam, HP de Koning, H Ibrahim, MS Sajid, MK Gould, ... European journal of medicinal chemistry 45 (3), 941-956, 2010 | 224 | 2010 |
Nucleobase transporters H de Koning, G Diallinas Molecular membrane biology 17 (2), 75-94, 2000 | 203 | 2000 |
Uptake of pentamidine in Trypanosoma brucei bruceiis mediated by three distinct transporters: implications for cross-resistance with arsenicals HP De Koning Molecular pharmacology 59 (3), 586-592, 2001 | 191 | 2001 |
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes N Baker, L Glover, JC Munday, D Aguinaga Andrés, MP Barrett, ... Proceedings of the National Academy of Sciences 109 (27), 10996-11001, 2012 | 177 | 2012 |
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent H Imamura, T Downing, F Van den Broeck, MJ Sanders, S Rijal, S Sundar, ... Elife 5, e12613, 2016 | 163 | 2016 |
Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs HP de Koning, SM Jarvis Molecular pharmacology 56 (6), 1162-1170, 1999 | 162 | 1999 |
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes DJ Bridges, MK Gould, B Nerima, P Mäser, RJS Burchmore, ... Molecular pharmacology 71 (4), 1098-1108, 2007 | 154 | 2007 |
Transporters in African trypanosomes: role in drug action and resistance HP de Koning International journal for parasitology 31 (5-6), 512-522, 2001 | 152 | 2001 |
Diamidines for human African trypanosomiasis M Paine, M Wang, WD Wilson, HP De Koning, CA Olson, G Pohlig, ... Current opinion in investigational drugs 11 (8), 876-883, 2010 | 149* | 2010 |
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of … JC Munday, AA Eze, N Baker, L Glover, C Clucas, D Aguinaga Andrés, ... Journal of Antimicrobial Chemotherapy 69 (3), 651-663, 2014 | 138 | 2014 |
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes HP de Koning, LF Anderson, M Stewart, RJS Burchmore, LJM Wallace, ... Antimicrobial Agents and Chemotherapy 48 (5), 1515-1519, 2004 | 130 | 2004 |
Diamidine Compounds: Selective Uptake and Targeting inPlasmodium falciparum AMW Stead, PG Bray, IG Edwards, HP DeKoning, BC Elford, PA Stocks, ... Molecular pharmacology 59 (5), 1298-1306, 2001 | 122 | 2001 |
Different substrate recognition motifs of human and trypanosome nucleobase transporters: selective uptake of purine antimetabolites LJM Wallace, D Candlish, HP De Koning Journal of Biological Chemistry 277 (29), 26149-26156, 2002 | 111 | 2002 |
Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets HP de Koning, MK Gould, GJ Sterk, H Tenor, S Kunz, E Luginbuehl, ... Journal of infectious diseases 206 (2), 229-237, 2012 | 105 | 2012 |