| Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen Journal of Biological Chemistry 277 (42), 39858-39866, 2002 | 778 | 2002 |
| Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators H Hieronymus, J Lamb, KN Ross, XP Peng, C Clement, A Rodina, ... Cancer cell 10 (4), 321-330, 2006 | 671 | 2006 |
| Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers K Jhaveri, T Taldone, S Modi, G Chiosis Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (3), 742-755, 2012 | 517 | 2012 |
| New arylthioindoles: Potent Inhibitors of tubulin polymerization. 2. Structure− activity relationships and molecular modeling studies G De Martino, MC Edler, G La Regina, A Coluccia, MC Barbera, D Barrow, ... Journal of medicinal chemistry 49 (3), 947-954, 2006 | 436 | 2006 |
| Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy P Koppikar, N Bhagwat, O Kilpivaara, T Manshouri, M Adli, T Hricik, F Liu, ... Nature 489 (7414), 155-159, 2012 | 384 | 2012 |
| BCR-ABL point mutants isolated from patients with imatinib mesylate–resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90 ME Gorre, K Ellwood-Yen, G Chiosis, N Rosen, CL Sawyers Blood, The Journal of the American Society of Hematology 100 (8), 3041-3044, 2002 | 382 | 2002 |
| Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models E Caldas-Lopes, L Cerchietti, JH Ahn, CC Clement, AI Robles, A Rodina, ... Proceedings of the National Academy of Sciences 106 (20), 8368-8373, 2009 | 371 | 2009 |
| A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells G Chiosis, MN Timaul, B Lucas, PN Munster, FF Zheng, L Sepp-Lorenzino, ... Chemistry & biology 8 (3), 289-299, 2001 | 368 | 2001 |
| Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies W Luo, F Dou, A Rodina, S Chip, J Kim, Q Zhao, K Moulick, J Aguirre, ... Proceedings of the National Academy of Sciences 104 (22), 9511-9516, 2007 | 358 | 2007 |
| Targeting Hsp90: small-molecule inhibitors and their clinical development T Taldone, A Gozman, R Maharaj, G Chiosis Current opinion in pharmacology 8 (4), 370-374, 2008 | 354 | 2008 |
| Development and application of Hsp90 inhibitors DB Solit, G Chiosis Drug discovery today 13 (1-2), 38-43, 2008 | 334 | 2008 |
| Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms R Rampal, J Ahn, O Abdel-Wahab, M Nahas, K Wang, D Lipson, GA Otto, ... Proceedings of the National Academy of Sciences 111 (50), E5401-E5410, 2014 | 312 | 2014 |
| Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 K Moulick, JH Ahn, H Zong, A Rodina, L Cerchietti, EM Gomes DaGama, ... Nature chemical biology 7 (11), 818-826, 2011 | 301 | 2011 |
| Hsp90: the vulnerable chaperone G Chiosis, M Vilenchik, J Kim, D Solit Drug discovery today 9 (20), 881-888, 2004 | 295 | 2004 |
| Heat shock protein 90 in neurodegenerative diseases W Luo, W Sun, T Taldone, A Rodina, G Chiosis Molecular neurodegeneration 5, 1-8, 2010 | 273 | 2010 |
| Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase G Chiosis, B Lucas, A Shtil, H Huezo, N Rosen Bioorganic & medicinal chemistry 10 (11), 3555-3564, 2002 | 264 | 2002 |
| The epichaperome is an integrated chaperome network that facilitates tumour survival A Rodina, T Wang, P Yan, EDG Gomes, MPS Dunphy, N Pillarsetty, ... Nature 538 (7625), 397-401, 2016 | 256 | 2016 |
| Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators JL Brodsky, G Chiosis Current Topics in Medicinal Chemistry 6 (11), 1215-1225, 2006 | 247 | 2006 |
| Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90 H He, D Zatorska, J Kim, J Aguirre, L Llauger, Y She, N Wu, ... Journal of medicinal chemistry 49 (1), 381-390, 2006 | 239 | 2006 |
| Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90 L Llauger, H He, J Kim, J Aguirre, N Rosen, U Peters, P Davies, G Chiosis Journal of medicinal chemistry 48 (8), 2892-2905, 2005 | 231 | 2005 |
