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The mechanism of eukaryotic CMG helicase activation ME Douglas, FA Ali, A Costa, JFX Diffley Nature 555 (7695), 265-268, 2018 | 241 | 2018 |
A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome AC Simon, JC Zhou, RL Perera, F van Deursen, C Evrin, ME Ivanova, ... Nature 510 (7504), 293-297, 2014 | 230 | 2014 |
Mechanisms for initiating cellular DNA replication A Costa, IV Hood, JM Berger Annual review of biochemistry 82 (1), 25-54, 2013 | 204 | 2013 |
Structural basis for retroviral integration into nucleosomes DP Maskell, L Renault, E Serrao, P Lesbats, R Matadeen, S Hare, ... Nature 523 (7560), 366-369, 2015 | 152 | 2015 |
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate F Abid Ali, L Renault, J Gannon, HL Gahlon, A Kotecha, JC Zhou, ... Nature communications 7 (1), 10708, 2016 | 129 | 2016 |
Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome CP Samora, J Saksouk, P Goswami, BO Wade, MR Singleton, PA Bates, ... Molecular cell 63 (3), 371-384, 2016 | 127 | 2016 |
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome A Costa, L Renault, P Swuec, T Petojevic, JJ Pesavento, I Ilves, ... Elife 3, e03273, 2014 | 127 | 2014 |
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM TCR Miller, J Locke, JF Greiwe, JFX Diffley, A Costa Nature 575 (7784), 704-710, 2019 | 122 | 2019 |
A structure-based mechanism for DNA entry into the cohesin ring TL Higashi, P Eickhoff, JS Sousa, J Locke, A Nans, HR Flynn, AP Snijders, ... Molecular cell 79 (6), 917-933. e9, 2020 | 119 | 2020 |
A supramolecular assembly mediates lentiviral DNA integration A Ballandras-Colas, DP Maskell, E Serrao, J Locke, P Swuec, ... Science 355 (6320), 93-95, 2017 | 112 | 2017 |
Microtubule nucleation properties of single human γTuRCs explained by their cryo-EM structure T Consolati, J Locke, J Roostalu, ZA Chen, J Gannon, J Asthana, WM Lim, ... Developmental cell 53 (5), 603-617. e8, 2020 | 109 | 2020 |
Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome P Goswami, F Abid Ali, ME Douglas, J Locke, A Purkiss, A Janska, ... Nature communications 9 (1), 5061, 2018 | 105 | 2018 |
The initiation of eukaryotic DNA replication A Costa, JFX Diffley Annual review of biochemistry 91 (1), 107-131, 2022 | 103 | 2022 |
CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome JC Zhou, A Janska, P Goswami, L Renault, F Abid Ali, A Kotecha, ... Proceedings of the National Academy of Sciences 114 (16), 4141-4146, 2017 | 97 | 2017 |
Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement T Petojevic, JJ Pesavento, A Costa, J Liang, Z Wang, JM Berger, ... Proceedings of the National Academy of Sciences 112 (3), E249-E258, 2015 | 95 | 2015 |
Cryo-EM structure of a licensed DNA replication origin F Abid Ali, ME Douglas, J Locke, VE Pye, A Nans, JFX Diffley, A Costa Nature communications 8 (1), 2241, 2017 | 87 | 2017 |
The MCM complex:(just) a replicative helicase? A Costa, S Onesti Biochemical Society Transactions 36 (1), 136-140, 2008 | 84 | 2008 |
Cdt1 stabilizes an open MCM ring for helicase loading J Frigola, J He, K Kinkelin, VE Pye, L Renault, ME Douglas, D Remus, ... Nature communications 8 (1), 15720, 2017 | 83 | 2017 |
Molecular basis for ATP-hydrolysis-driven DNA translocation by the CMG helicase of the eukaryotic replisome P Eickhoff, HB Kose, F Martino, T Petojevic, FA Ali, J Locke, N Tamberg, ... Cell reports 28 (10), 2673-2688. e8, 2019 | 78 | 2019 |