Drug delivery systems: entering the mainstream TM Allen, PR Cullis Science 303 (5665), 1818-1822, 2004 | 5669 | 2004 |
Liposomal drug delivery systems: from concept to clinical applications TM Allen, PR Cullis Advanced drug delivery reviews 65 (1), 36-48, 2013 | 4897 | 2013 |
Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential MJ Hope, MB Bally, G Webb, PR Cullis Biochimica et Biophysica Acta (BBA)-Biomembranes 812 (1), 55-65, 1985 | 2685 | 1985 |
Vesicles of variable sizes produced by a rapid extrusion procedure LD Mayer, MJ Hope, PR Cullis Biochimica et Biophysica Acta (BBA)-Biomembranes 858 (1), 161-168, 1986 | 2217 | 1986 |
Rational design of cationic lipids for siRNA delivery SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ... Nature biotechnology 28 (2), 172-176, 2010 | 1887 | 2010 |
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ... Angewandte Chemie 124 (34), 8657-8661, 2012 | 1145 | 2012 |
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ... Nature nanotechnology 14 (12), 1084-1087, 2019 | 1049 | 2019 |
Lipid nanoparticle systems for enabling gene therapies PR Cullis, MJ Hope Molecular Therapy 25 (7), 1467-1475, 2017 | 819 | 2017 |
Liposomal compositions for enhanced retention of bioactive agents MB Bally, NL Boman, PR Cullis, LD Mayer US Patent 5,595,756, 1997 | 800 | 1997 |
The current landscape of nucleic acid therapeutics JA Kulkarni, D Witzigmann, SB Thomson, S Chen, BR Leavitt, PR Cullis, ... Nature nanotechnology 16 (6), 630-643, 2021 | 745 | 2021 |
Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA NM Belliveau, J Huft, PJC Lin, S Chen, AKK Leung, TJ Leaver, AW Wild, ... Molecular Therapy-Nucleic Acids 1, 2012 | 735 | 2012 |
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids IM Hafez, N Maurer, PR Cullis Gene therapy 8 (15), 1188-1196, 2001 | 696 | 2001 |
Nomenclature for synthetic gene delivery systems PL Felgner, Y Barenholz, JP Behr, SH Cheng, P Cullis, L Huang, ... Human gene therapy 8 (5), 511-512, 1997 | 650 | 1997 |
Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. A Chonn, SC Semple, PR Cullis Journal of Biological Chemistry 267 (26), 18759-18765, 1992 | 599 | 1992 |
Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles LD Mayer, MJ Hope, PR Cullis, AS Janoff Biochimica et Biophysica Acta (BBA)-Biomembranes 817 (1), 193-196, 1985 | 594 | 1985 |
Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures SC Semple, SK Klimuk, TO Harasym, N Dos Santos, SM Ansell, KF Wong, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1510 (1-2), 152-166, 2001 | 569 | 2001 |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer JJ Wheeler, MB Bally, YP Zhang, DL Reimer, M Hope, PR Cullis, ... US Patent 5,976,567, 1999 | 546* | 1999 |
The liposomal formulation of doxorubicin SA Abraham, DN Waterhouse, LD Mayer, PR Cullis, TD Madden, ... Methods in enzymology 391, 71-97, 2005 | 544 | 2005 |
Generation of multilamellar and unilamellar phospholipid vesicles MJ Hope, MB Bally, LD Mayer, AS Janoff, PR Cullis Chemistry and physics of lipids 40 (2-4), 89-107, 1986 | 544 | 1986 |
The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study PR Cullis, B De Kruijff Biochimica et Biophysica Acta (BBA)-Biomembranes 513 (1), 31-42, 1978 | 512 | 1978 |