Aligned collagen is a prognostic signature for survival in human breast carcinoma MW Conklin, JC Eickhoff, KM Riching, CA Pehlke, KW Eliceiri, ... The American journal of pathology 178 (3), 1221-1232, 2011 | 1398 | 2011 |
In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia MC Skala, KM Riching, A Gendron-Fitzpatrick, J Eickhoff, KW Eliceiri, ... Proceedings of the National Academy of Sciences 104 (49), 19494-19499, 2007 | 1144 | 2007 |
3D collagen alignment limits protrusions to enhance breast cancer cell persistence KM Riching, BL Cox, MR Salick, C Pehlke, AS Riching, SM Ponik, ... Biophysical journal 107 (11), 2546-2558, 2014 | 480 | 2014 |
In vivo multiphoton fluorescence lifetime imaging<?xpp qa?> of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia MC Skala, KM Riching, DK Bird, A Gendron-Fitzpatrick, J Eickhoff, ... Journal of biomedical optics 12 (2), 024014-024014-10, 2007 | 410 | 2007 |
Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) based … V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ... Journal of medicinal chemistry 62 (2), 699-726, 2018 | 281 | 2018 |
Quantitative live-cell kinetic degradation and mechanistic profiling of PROTAC mode of action KM Riching, S Mahan, CR Corona, M McDougall, JD Vasta, MB Robers, ... ACS chemical biology 13 (9), 2758-2770, 2018 | 232 | 2018 |
Filamin A–β1 integrin complex tunes epithelial cell response to matrix tension S Gehler, M Baldassarre, Y Lad, JL Leight, MA Wozniak, KM Riching, ... Molecular biology of the cell 20 (14), 3224-3238, 2009 | 148 | 2009 |
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ... Nature chemical biology 17 (11), 1157-1167, 2021 | 132 | 2021 |
A three-dimensional computational model of collagen network mechanics B Lee, X Zhou, K Riching, KW Eliceiri, PJ Keely, SA Guelcher, AM Weaver, ... PloS one 9 (11), e111896, 2014 | 83 | 2014 |
Discovery and resistance mechanism of a selective CDK12 degrader B Jiang, Y Gao, J Che, W Lu, IH Kaltheuner, R Dries, M Kalocsay, ... Nature chemical biology 17 (6), 675-683, 2021 | 82 | 2021 |
Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression S Gehler, SM Ponik, KM Riching, PJ Keely Critical Reviews™ in Eukaryotic Gene Expression 23 (2), 2013 | 74 | 2013 |
Monitoring and deciphering protein degradation pathways inside cells DL Daniels, KM Riching, M Urh Drug Discovery Today: Technologies 31, 61-68, 2019 | 57 | 2019 |
Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor … LE Kilpatrick, R Friedman-Ohana, DC Alcobia, K Riching, CJ Peach, ... Biochemical Pharmacology 136, 62-75, 2017 | 57 | 2017 |
R-Ras regulates β1-integrin trafficking via effects on membrane ruffling and endocytosis MW Conklin, A Ada-Nguema, M Parsons, KM Riching, PJ Keely BMC cell biology 11, 1-15, 2010 | 54 | 2010 |
In vivo multiphoton fluorescence lifetime imaging of protein-bound and free NADH in normal and pre-cancerous epithelia MC Skala, KM Riching, DK Bird, A Gendron-Fitzpatrick, J Eickhoff, ... Journal of biomedical optics 12 (2), 024014, 2007 | 49 | 2007 |
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs N Bai, KM Riching, A Makaju, H Wu, TM Acker, SC Ou, Y Zhang, X Shen, ... Journal of Biological Chemistry 298 (4), 2022 | 39 | 2022 |
Effect of optical clearing agents on the in vivo optical properties of squamous epithelial tissue SR Millon, KM Roldan‐Perez, KM Riching, GM Palmer, N Ramanujam Lasers in Surgery and Medicine: The Official Journal of the American Society …, 2006 | 39 | 2006 |
CDK family PROTAC profiling reveals distinct kinetic responses and cell cycle–dependent degradation of CDK2 KM Riching, MK Schwinn, JD Vasta, MB Robers, T Machleidt, M Urh, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (4), 560-569, 2021 | 29 | 2021 |
Preparation of 3D collagen gels and microchannels for the study of 3D interactions in vivo B Burkel, BA Morris, SM Ponik, KM Riching, KW Eliceiri, PJ Keely JoVE (Journal of Visualized Experiments), e53989, 2016 | 29 | 2016 |
Targeted protein degradation phenotypic studies using HaloTag CRISPR/Cas9 endogenous tagging coupled with HaloPROTAC3 EA Caine, SD Mahan, RL Johnson, AN Nieman, N Lam, CR Warren, ... Current Protocols in Pharmacology 91 (1), e81, 2020 | 27 | 2020 |