Multiplex genome engineering using CRISPR/Cas systems L Cong, FA Ran, D Cox, S Lin, R Barretto, N Habib, PD Hsu, X Wu, ... Science 339 (6121), 819-823, 2013 | 18143 | 2013 |
Genome engineering using the CRISPR-Cas9 system F Ran, PD Hsu, J Wright, V Agarwala, DA Scott, F Zhang Nature protocols 8 (11), 2281-2308, 2013 | 11999 | 2013 |
Development and applications of CRISPR-Cas9 for genome engineering PD Hsu, ES Lander, F Zhang Cell 157 (6), 1262-1278, 2014 | 6681 | 2014 |
Millisecond-timescale, genetically targeted optical control of neural activity ES Boyden, F Zhang, E Bamberg, G Nagel, K Deisseroth Nature neuroscience 8 (9), 1263-1268, 2005 | 5812 | 2005 |
Genome-scale CRISPR-Cas9 knockout screening in human cells O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ... Science 343 (6166), 84-87, 2014 | 5568 | 2014 |
DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nature biotechnology 31 (9), 827-832, 2013 | 5433 | 2013 |
Improved vectors and genome-wide libraries for CRISPR screening NE Sanjana, O Shalem, F Zhang Nature methods 11 (8), 783-784, 2014 | 4878 | 2014 |
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... cell 163 (3), 759-771, 2015 | 4745 | 2015 |
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering H Wang, H Yang, CS Shivalila, MM Dawlaty, AW Cheng, F Zhang, ... cell 153 (4), 910-918, 2013 | 4370 | 2013 |
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity FA Ran, PD Hsu, CY Lin, JS Gootenberg, S Konermann, AE Trevino, ... Cell 154 (6), 1380-1389, 2013 | 4210 | 2013 |
In vivo genome editing using Staphylococcus aureus Cas9 FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ... Nature 520 (7546), 186-191, 2015 | 3044 | 2015 |
RNA-guided editing of bacterial genomes using CRISPR-Cas systems W Jiang, D Bikard, D Cox, F Zhang, LA Marraffini Nature biotechnology 31 (3), 233-239, 2013 | 3033 | 2013 |
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex S Konermann, MD Brigham, AE Trevino, J Joung, OO Abudayyeh, ... Nature 517 (7536), 583-588, 2015 | 2937 | 2015 |
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance VS Sohal, F Zhang, O Yizhar, K Deisseroth Nature 459 (7247), 698-702, 2009 | 2847 | 2009 |
Nucleic acid detection with CRISPR-Cas13a/C2c2 JS Gootenberg, OO Abudayyeh, JW Lee, P Essletzbichler, AJ Dy, J Joung, ... Science 356 (6336), 438-442, 2017 | 2844 | 2017 |
Driving fast-spiking cells induces gamma rhythm and controls sensory responses JA Cardin, M Carlén, K Meletis, U Knoblich, F Zhang, K Deisseroth, ... Nature 459 (7247), 663-667, 2009 | 2826 | 2009 |
Rationally engineered Cas9 nucleases with improved specificity IM Slaymaker, L Gao, B Zetsche, DA Scott, WX Yan, F Zhang Science 351 (6268), 84-88, 2016 | 2616 | 2016 |
Crystal structure of Cas9 in complex with guide RNA and target DNA H Nishimasu, FA Ran, PD Hsu, S Konermann, SI Shehata, N Dohmae, ... Cell 156 (5), 935-949, 2014 | 2339 | 2014 |
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2156 | 2016 |
Multimodal fast optical interrogation of neural circuitry F Zhang, LP Wang, M Brauner, JF Liewald, K Kay, N Watzke, PG Wood, ... Nature 446 (7136), 633-639, 2007 | 2148 | 2007 |