| Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and … DC Greenbaum, Z Mackey, E Hansell, P Doyle, J Gut, CR Caffrey, ... Journal of medicinal chemistry 47 (12), 3212-3219, 2004 | 357 | 2004 |
| Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ... Science translational medicine 9 (387), eaad9735, 2017 | 249 | 2017 |
| Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds EM Guantai, K Ncokazi, TJ Egan, J Gut, PJ Rosenthal, PJ Smith, ... Bioorganic & medicinal chemistry 18 (23), 8243-8256, 2010 | 246 | 2010 |
| Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents K Chibale, M Visser, D van Schalkwyk, PJ Smith, A Saravanamuthu, ... Tetrahedron 59 (13), 2289-2296, 2003 | 238 | 2003 |
| The role of natural products in drug discovery and development against neglected tropical diseases PM Cheuka, G Mayoka, P Mutai, K Chibale Molecules 22 (1), 58, 2016 | 235 | 2016 |
| Synthesis, antimalarial and antitubercular activity of acetylenic chalcones RH Hans, EM Guantai, C Lategan, PJ Smith, B Wan, SG Franzblau, J Gut, ... Bioorganic & medicinal chemistry letters 20 (3), 942-944, 2010 | 229 | 2010 |
| Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives I Chiyanzu, C Clarkson, PJ Smith, J Lehman, J Gut, PJ Rosenthal, ... Bioorganic & medicinal chemistry 13 (9), 3249-3261, 2005 | 225 | 2005 |
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain I Chiyanzu, E Hansell, J Gut, PJ Rosenthal, JH McKerrow, K Chibale Bioorganic & medicinal chemistry letters 13 (20), 3527-3530, 2003 | 203 | 2003 |
| The state of the art in anti-malarial drug discovery and development J N Burrows, K Chibale, T NC Wells Current topics in medicinal chemistry 11 (10), 1226-1254, 2011 | 193 | 2011 |
| Antiviral drug discovery: preparing for the next pandemic CS Adamson, K Chibale, RJM Goss, M Jaspars, DJ Newman, ... Chemical Society Reviews 50 (6), 3647-3655, 2021 | 192 | 2021 |
| Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery M Hohman, K Gregory, K Chibale, PJ Smith, S Ekins, B Bunin Drug discovery today 14 (5-6), 261-270, 2009 | 160 | 2009 |
| 3, 5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential Y Younis, F Douelle, TS Feng, DG Cabrera, CL Manach, AT Nchinda, ... Journal of medicinal chemistry 55 (7), 3479-3487, 2012 | 159 | 2012 |
| Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine K Chibale, H Haupt, H Kendrick, V Yardley, A Saravanamuthu, ... Bioorganic & medicinal chemistry letters 11 (19), 2655-2657, 2001 | 137 | 2001 |
| Synthesis and antiplasmodial activity in vitro of new ferrocene–chloroquine analogues P Beagley, MAL Blackie, K Chibale, C Clarkson, R Meijboom, JR Moss, ... Dalton Transactions, 3046-3051, 2003 | 135 | 2003 |
| Antimalarial Pyrido[1,2-a]benzimidazoles AJ Ndakala, RK Gessner, PW Gitari, N October, KL White, A Hudson, ... Journal of medicinal chemistry 54 (13), 4581-4589, 2011 | 131 | 2011 |
| Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis M Njoroge, NM Njuguna, P Mutai, DSB Ongarora, PW Smith, K Chibale Chemical reviews 114 (22), 11138-11163, 2014 | 125 | 2014 |
| Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity P Chellan, S Nasser, L Vivas, K Chibale, GS Smith Journal of organometallic chemistry 695 (19-20), 2225-2232, 2010 | 121 | 2010 |
| New amine and urea analogs of ferrochloroquine: synthesis, antimalarial activity in vitro and electrochemical studies K Chibale, JR Moss, M Blackie, D van Schalkwyk, PJ Smith Tetrahedron Letters 41 (32), 6231-6235, 2000 | 121 | 2000 |
| The synthesis and antiparasitic activity of aryl-and ferrocenyl-derived thiosemicarbazone ruthenium (II)–arene complexes M Adams, Y Li, H Khot, C De Kock, PJ Smith, K Land, K Chibale, ... Dalton Transactions 42 (13), 4677-4685, 2013 | 118 | 2013 |
| Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV KC Nicolaou, JI Trujillo, K Chibale Tetrahedron 53 (26), 8751-8778, 1997 | 118 | 1997 |
