Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment SQ Zhang, W Yang, MI Kontaridis, TG Bivona, G Wen, T Araki, J Luo, ... Molecular cell 13 (3), 341-355, 2004 | 554 | 2004 |
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects MI Kontaridis, KD Swanson, FS David, D Barford, BG Neel Journal of Biological Chemistry 281 (10), 6785-6792, 2006 | 374 | 2006 |
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation TM Marin, K Keith, B Davies, DA Conner, P Guha, D Kalaitzidis, X Wu, ... The Journal of clinical investigation 121 (3), 1026-1043, 2011 | 291 | 2011 |
Stops along the RAS pathway in human genetic disease M Bentires-Alj, MI Kontaridis, BG Neel Nature medicine 12 (3), 283-285, 2006 | 248 | 2006 |
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway MI Kontaridis, S Eminaga, M Fornaro, CI Zito, R Sordella, J Settleman, ... Molecular and cellular biology, 2004 | 128 | 2004 |
Phosphatase-dependent and-independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis RA Stewart, T Sanda, HR Widlund, S Zhu, KD Swanson, AD Hurley, ... Developmental cell 18 (5), 750-762, 2010 | 126 | 2010 |
Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation E Dolmatova, G Spagnol, D Boassa, JR Baum, K Keith, C Ambrosi, ... American Journal of Physiology-Heart and Circulatory Physiology 303 (10 …, 2012 | 123 | 2012 |
SHP‐2 regulates the phosphatidylinositide 3′‐kinase/Akt pathway and suppresses caspase 3‐mediated apoptosis C Ivins Zito, MI Kontaridis, M Fornaro, GS Feng, AM Bennett Journal of cellular physiology 199 (2), 227-236, 2004 | 116 | 2004 |
Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein … MI Kontaridis, W Yang, KK Bence, D Cullen, B Wang, N Bodyak, Q Ke, ... Circulation 117 (11), 1423-1435, 2008 | 111 | 2008 |
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis J Lauriol, K Keith, F Jaffré, A Couvillon, A Saci, SA Goonasekera, ... Science signaling 7 (348), ra100-ra100, 2014 | 91 | 2014 |
Cardiac inflammation in COVID-19: Lessons from heart failure SD Unudurthi, P Luthra, RJC Bose, JR McCarthy, MI Kontaridis Life sciences 260, 118482, 2020 | 90 | 2020 |
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus J Wang, M Mizui, LF Zeng, R Bronson, M Finnell, C Terhorst, VC Kyttaris, ... The Journal of clinical investigation 126 (6), 2077-2092, 2016 | 77 | 2016 |
Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a rapamycin analog A Hahn, J Lauriol, J Thul, K Behnke‐Hall, T Logeswaran, A Schänzer, ... American Journal of Medical Genetics Part A 167 (4), 744-751, 2015 | 74 | 2015 |
Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts MI Kontaridis, X Liu, L Zhang, AM Bennett Molecular and cellular biology 22 (11), 3875-3891, 2002 | 74 | 2002 |
Resveratrol inhibits angiotensin II-and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2 UGB Haider, TU Roos, MI Kontaridis, BG Neel, D Sorescu, KK Griendling, ... Molecular pharmacology 68 (1), 41-48, 2005 | 68 | 2005 |
Engineering spatial-organized cardiac organoids for developmental toxicity testing P Hoang, A Kowalczewski, S Sun, TS Winston, AM Archilla, SM Lemus, ... Stem Cell Reports 16 (5), 1228-1244, 2021 | 57 | 2021 |
Nitric oxide contributes to adriamycin's antitumor effect DS Lind, MI Kontaridis, PD Edwards, MD Josephs, LL Moldawer, ... Journal of Surgical Research 69 (2), 283-287, 1997 | 55 | 1997 |
Inducible pluripotent stem cell–derived cardiomyocytes reveal aberrant extracellular regulated kinase 5 and mitogen-activated protein kinase kinase 1/2 signaling concomitantly … F Jaffré, CL Miller, A Schänzer, T Evans, AE Roberts, A Hahn, ... Circulation 140 (3), 207-224, 2019 | 54 | 2019 |
PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots? J Lauriol, MI Kontaridis Trends in cardiovascular medicine 21 (4), 97-104, 2011 | 53 | 2011 |
DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress B Simonson, V Subramanya, MC Chan, A Zhang, H Franchino, ... Science signaling 10 (468), eaaf5967, 2017 | 50 | 2017 |