Large conserved domains of low DNA methylation maintained by Dnmt3a M Jeong, D Sun, M Luo, Y Huang, GA Challen, B Rodriguez, X Zhang, ... Nature genetics 46 (1), 17-23, 2014 | 321 | 2014 |
The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends X Chen, D Cui, A Papusha, X Zhang, CD Chu, J Tang, K Chen, X Pan, ... Nature 489 (7417), 576-580, 2012 | 278 | 2012 |
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells X Zhang, J Su, M Jeong, M Ko, Y Huang, HJ Park, A Guzman, Y Lei, ... Nature genetics 48 (9), 1014-1023, 2016 | 256 | 2016 |
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein Y Lei, X Zhang, J Su, M Jeong, MC Gundry, YH Huang, Y Zhou, W Li, ... Nature communications 8 (1), 16026, 2017 | 216 | 2017 |
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A YH Huang, J Su, Y Lei, L Brunetti, MC Gundry, X Zhang, M Jeong, W Li, ... Genome biology 18, 1-11, 2017 | 215 | 2017 |
Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia TL Cuellar, AM Herzner, X Zhang, Y Goyal, C Watanabe, BA Friedman, ... Journal of Cell Biology 216 (11), 3535-3549, 2017 | 180 | 2017 |
Long non-coding RNAs control hematopoietic stem cell function M Luo, M Jeong, D Sun, HJ Park, BAT Rodriguez, Z Xia, L Yang, X Zhang, ... Cell stem cell 16 (4), 426-438, 2015 | 179 | 2015 |
DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias L Yang, B Rodriguez, A Mayle, HJ Park, X Lin, M Luo, M Jeong, CV Curry, ... Cancer cell 29 (6), 922-934, 2016 | 162 | 2016 |
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart A Karlstaedt, X Zhang, H Vitrac, R Harmancey, H Vasquez, JH Wang, ... Proceedings of the National Academy of Sciences 113 (37), 10436-10441, 2016 | 120 | 2016 |
Homeobox oncogene activation by pan-cancer DNA hypermethylation J Su, YH Huang, X Cui, X Wang, X Zhang, Y Lei, J Xu, X Lin, K Chen, J Lv, ... Genome biology 19, 1-12, 2018 | 111 | 2018 |
Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance H Wang, W Wu, HW Wang, S Wang, Y Chen, X Zhang, J Yang, S Zhao, ... Neuro-oncology 12 (7), 679-686, 2010 | 101 | 2010 |
Large DNA methylation nadirs anchor chromatin loops maintaining hematopoietic stem cell identity X Zhang, M Jeong, X Huang, XQ Wang, X Wang, W Zhou, MS Shamim, ... Molecular cell 78 (3), 506-521. e6, 2020 | 77 | 2020 |
MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1 R Zhang, H Luo, S Wang, W Chen, Z Chen, HW Wang, Y Chen, J Yang, ... Neuro-oncology 16 (11), 1510-1522, 2014 | 66 | 2014 |
VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells Y Chen, D Meng, H Wang, R Sun, D Wang, S Wang, J Fan, Y Zhao, ... Neuro-oncology 17 (3), 407-418, 2015 | 62 | 2015 |
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, ... Nature chemical biology 17 (7), 784-793, 2021 | 40 | 2021 |
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis X Zhang, X Wang, XQD Wang, J Su, N Putluri, T Zhou, Y Qu, M Jeong, ... Blood, The Journal of the American Society of Hematology 135 (11), 845-856, 2020 | 31 | 2020 |
Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies H Zeng, H He, L Guo, J Li, M Lee, W Han, AG Guzman, S Zang, Y Zhou, ... Cancer letters 467, 1-8, 2019 | 29 | 2019 |
Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia XQD Wang, D Fan, Q Han, Y Liu, H Miao, X Wang, Q Li, D Chen, H Gore, ... Cancer discovery 13 (3), 724-745, 2023 | 28 | 2023 |
Connecting high-resolution 3D chromatin organization with epigenomics F Feng, Y Yao, XQD Wang, X Zhang, J Liu Nature communications 13 (1), 2054, 2022 | 21 | 2022 |
A cell type-specific class of chromatin loops anchored at large DNA methylation nadirs M Jeong, X Huang, X Zhang, J Su, MS Shamim, ID Bochkov, J Reyes, ... Biorxiv, 212928, 2017 | 15 | 2017 |