| Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome XW Yang, P Model, N Heintz Nature biotechnology 15 (9), 859-865, 1997 | 766 | 1997 |
| Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice M Gray, DI Shirasaki, C Cepeda, VM André, B Wilburn, XH Lu, J Tao, ... Journal of Neuroscience 28 (24), 6182-6195, 2008 | 737 | 2008 |
| FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains MK Lobo, SL Karsten, M Gray, DH Geschwind, XW Yang Nature neuroscience 9 (3), 443-452, 2006 | 487 | 2006 |
| The mouse cortico-striatal projectome H Hintiryan, NN Foster, I Bowman, M Bay, MY Song, L Gou, S Yamashita, ... Nature neuroscience 19 (8), 1100-1114, 2016 | 472 | 2016 |
| Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ... Nature neuroscience 19 (4), 623-633, 2016 | 369 | 2016 |
| Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models L Menalled, BF El-Khodor, M Patry, M Suárez-Fariñas, SJ Orenstein, ... Neurobiology of disease 35 (3), 319-336, 2009 | 369 | 2009 |
| Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism O Peñagarikano, MT Lázaro, XH Lu, A Gordon, H Dong, HA Lam, E Peles, ... Science translational medicine 7 (271), 271ra8-271ra8, 2015 | 368 | 2015 |
| Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets M Jiang, J Wang, J Fu, L Du, H Jeong, T West, L Xiang, Q Peng, Z Hou, ... Nature medicine 18 (1), 153-158, 2012 | 367 | 2012 |
| Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice X Gu, ER Greiner, R Mishra, R Kodali, A Osmand, S Finkbeiner, ... Neuron 64 (6), 828-840, 2009 | 359 | 2009 |
| Network organization of the huntingtin proteomic interactome in mammalian brain DI Shirasaki, ER Greiner, I Al-Ramahi, M Gray, P Boontheung, ... Neuron 75 (1), 41-57, 2012 | 328 | 2012 |
| Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, ... Neuron 97 (5), 1032-1048. e5, 2018 | 321 | 2018 |
| Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control RG Yau, K Doerner, ER Castellanos, DL Haakonsen, A Werner, N Wang, ... Cell 171 (4), 918-933. e20, 2017 | 295 | 2017 |
| A multimodal cell census and atlas of the mammalian primary motor cortex Principal manuscript editors, Analysis coordination, ... Nature 598 (7879), 86-102, 2021 | 287 | 2021 |
| Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kγ origin of replication S Gong, XW Yang, C Li, N Heintz Genome research 12 (12), 1992-1998, 2002 | 268 | 2002 |
| Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway MD Haustein, S Kracun, XH Lu, T Shih, O Jackson-Weaver, X Tong, J Xu, ... Neuron 82 (2), 413-429, 2014 | 255 | 2014 |
| Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice X Gu, C Li, W Wei, V Lo, S Gong, SH Li, T Iwasato, S Itohara, XJ Li, I Mody, ... Neuron 46 (3), 433-444, 2005 | 253 | 2005 |
| Identifying polyglutamine protein species in situ that best predict neurodegeneration J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ... Nature chemical biology 7 (12), 925-934, 2011 | 235 | 2011 |
| Morphological diversity of single neurons in molecularly defined cell types H Peng, P Xie, L Liu, X Kuang, Y Wang, L Qu, H Gong, S Jiang, A Li, ... Nature 598 (7879), 174-181, 2021 | 225 | 2021 |
| Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels S Horvath, P Langfelder, S Kwak, J Aaronson, J Rosinski, TF Vogt, ... Aging (Albany NY) 8 (7), 1485, 2016 | 222 | 2016 |
| Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes MB Victor, M Richner, HE Olsen, SW Lee, AM Monteys, C Ma, CJ Huh, ... Nature neuroscience 21 (3), 341-352, 2018 | 206 | 2018 |
Peter LangfelderAssistant Researcher, University of California, Los Angeles在 mednet.ucla.edu 的电子邮件经过验证
