IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner R Loschinski, M Böttcher, A Stoll, H Bruns, A Mackensen, D Mougiakakos Oncotarget 9 (17), 13125, 2018 | 87 | 2018 |
Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation R Jitschin, M Böttcher, D Saul, S Lukassen, H Bruns, R Loschinski, ... Leukemia 33 (7), 1783-1796, 2019 | 72 | 2019 |
Mesenchymal stromal cells disrupt mTOR-signaling and aerobic glycolysis during T-cell activation M Böttcher, A D. Hofmann, H Bruns, M Haibach, R Loschinski, D Saul, ... Stem Cells 34 (2), 516-521, 2016 | 54 | 2016 |
Palmitoylated proteins on AML-derived extracellular vesicles promote myeloid-derived suppressor cell differentiation via TLR2/Akt/mTOR signaling S Tohumeken, R Baur, M Böttcher, A Stoll, R Loschinski, K Panagiotidis, ... Cancer Research 80 (17), 3663-3676, 2020 | 38 | 2020 |
TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases S Drube, F Weber, C Göpfert, R Loschinski, M Rothe, F Boelke, ... Oncotarget 6 (30), 28833, 2015 | 16 | 2015 |
Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells S Drube, F Weber, R Loschinski, M Beyer, M Rothe, A Rabenhorst, ... Oncotarget 6 (7), 5354, 2015 | 16 | 2015 |
CLL-derived extracellular vesicles impair T-cell activation and foster T-cell exhaustion via multiple immunological checkpoints M Böttcher, R Böttcher-Loschinski, S Kahlfuss, M Aigner, A Gießl, ... Cells 11 (14), 2176, 2022 | 12 | 2022 |
IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt+ Treg generation via enhanced IL‐6 induction S Drube, S Müller, F Weber, P Wegner, R Böttcher‐Loschinski, M Gaestel, ... Immunology 163 (1), 86-97, 2021 | 9 | 2021 |
TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment N Jantz-Naeem, R Böttcher-Loschinski, K Borucki, M Mitchell-Flack, ... Frontiers in Oncology 13, 1060112, 2023 | 7 | 2023 |
Impact of Nrf2 expression in reconstituting T-cells of allogeneic hematopoietic stem cell transplanted patients F Karl, A Stoll, R Böttcher-Loschinski, M Böttcher, R Baur, B Jacobs, ... Leukemia 35 (3), 910-915, 2021 | 7 | 2021 |
Oxidative DNA damage in reconstituting T cells is associated with relapse and inferior survival after allo-SCT F Karl, C Liang, R Boettcher-Loschinski, A Stoll, C Flamann, S Richter, ... Blood, The Journal of the American Society of Hematology 141 (13), 1626-1639, 2023 | 6 | 2023 |
Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy R Baur, F Karl, R Böttcher-Loschinski, A Stoll, S Völkl, A Gießl, C Flamann, ... Journal for Immunotherapy of Cancer 11 (3), 2023 | 4 | 2023 |
Synergistic lethality in chronic myeloid leukemia–targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment L Häselbarth, S Gamali, D Saul, M Krumbholz, R Böttcher-Loschinski, ... BMC cancer 23 (1), 1153, 2023 | 1 | 2023 |
Lipotoxicity as a Barrier for T Cell-Based Therapies R Böttcher-Loschinski, J Rial Saborido, M Böttcher, S Kahlfuss, ... Biomolecules 12 (9), 1182, 2022 | 1 | 2022 |
Extracellular Vesicles of CLL Cells affect T-Cell Activation and promote their Depletion via diverse immunological Checkpoints M Boettcher, R Boettcher-Loschinski, A Giessl, U Schloetzer-Schrehardt, ... ONCOLOGY RESEARCH AND TREATMENT 45 (SUPPL 2), 15-15, 2022 | | 2022 |
Profiling extracellular vesicles (EV) in patients with acute GvHD after allogeneic stem cell transplantation R Baur, M Boettcher, A Stoll, R Boettcher-Loschinski, S Voelkl, W Roesler, ... ONCOLOGY RESEARCH AND TREATMENT 43 (SUPPL 4), 49-49, 2020 | | 2020 |
Monitoring of the immunometabolic profile of reconstituting leukocytes upon autologous peripheral blood stem cell transplantation S Richter, B Jacobs, M Boettcher, A Stoll, R Boettcher-Loschinski, ... ONCOLOGY RESEARCH AND TREATMENT 42, 152-152, 2019 | | 2019 |
Oxidative stress upon allogeneic hematopoietic stem cell transplantation and its impact on the reconstituting immune system F Karl, R Boettcher-Loschinski, A Stoll, S Voelkl, W Roesler, A Mackensen, ... ONCOLOGY RESEARCH AND TREATMENT 42, 205-205, 2019 | | 2019 |
IL-21-Mediated Immunometabolic Modulation of T-Cells R Böttcher-Loschinski Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019 | | 2019 |