Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice HS McLoughlin, LR Moore, R Chopra, R Komlo, M McKenzie, ... Annals of neurology 84 (1), 64-77, 2018 | 154 | 2018 |
Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability JM Dell'Orco, AH Wasserman, R Chopra, MAC Ingram, YS Hu, V Singh, ... Journal of Neuroscience 35 (32), 11292-11307, 2015 | 120 | 2015 |
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD ML Schultz, KL Krus, S Kaushik, D Dang, R Chopra, L Qi, VG Shakkottai, ... Nature communications 9 (1), 3671, 2018 | 113 | 2018 |
Targeting potassium channels to treat cerebellar ataxia DD Bushart, R Chopra, V Singh, GG Murphy, H Wulff, VG Shakkottai Annals of clinical and translational neurology 5 (3), 297-314, 2018 | 66 | 2018 |
Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia R Chopra, AH Wasserman, SM Pulst, CI De Zeeuw, VG Shakkottai Human molecular genetics 27 (8), 1396-1410, 2018 | 40 | 2018 |
Untangling the Dravet syndrome seizure network: the changing face of a rare genetic epilepsy: the paradox of Dravet syndrome R Chopra, LL Isom Epilepsy currents 14 (2), 86-89, 2014 | 40 | 2014 |
Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia R Chopra, VG Shakkottai Future neurology 9 (2), 187-196, 2014 | 34 | 2014 |
Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1 R Chopra, DD Bushart, JP Cooper, D Yellajoshyula, LM Morrison, ... Human molecular genetics 29 (19), 3249-3265, 2020 | 30 | 2020 |
Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1 R Chopra, DD Bushart, VG Shakkottai PLoS One 13 (5), e0198040, 2018 | 30 | 2018 |
MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias AS Brown, P Meera, B Altindag, R Chopra, EM Perkins, S Paul, ... Proceedings of the National Academy of Sciences 115 (52), E12407-E12416, 2018 | 28 | 2018 |
The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders R Chopra, VG Shakkottai Neurotherapeutics 11 (4), 751-763, 2014 | 26 | 2014 |
Deriving early single-rosette brain organoids from human pluripotent stem cells AM Tidball, W Niu, Q Ma, TN Takla, JC Walker, JL Margolis, ... Stem Cell Reports 18 (12), 2498-2514, 2023 | 9 | 2023 |
Self-organizing single-rosette brain organoids from human pluripotent stem cells AM Tidball, W Niu, Q Ma, TN Takla, JC Walker, JL Margolis, ... Biorxiv, 2022.02. 28.482350, 2022 | 7 | 2022 |
Increased dendritic excitability and calcium-dependent PKC activation: a novel mechanism underlying Purkinje neuron dendritic degeneration in cerebellar ataxias R Chopra, AG Wasserman, DD Bushart, JM Dell'Orco, VG Shakkottai ANNALS OF NEUROLOGY 80, S33-S34, 2016 | 4 | 2016 |
Preoperative stress testing before elective arthroplasty: A teachable moment R Chopra, K Patel, MW Rich JAMA Internal Medicine 181 (12), 1633-1634, 2021 | 1 | 2021 |
Dendritic Excitability and Protein Kinase C Activity Regulate Purkinje Neuron Dendrite Degeneration in Cerebellar Ataxia R Chopra | | 2020 |
Regional Differences in Purkinje Neuron Degeneration Reveal a Region-Specific Dysregulated Ion Channel Module in Spinocerebellar Ataxia Type 1 R Chopra, DD Bushart, JP Cooper, D Yellajoshyula, H Huang, ... ANNALS OF NEUROLOGY 86, S85-S85, 2019 | | 2019 |
MTSS1/Src family kinase dysregulation contributes to multiple neurodegenerative disorders. A Brown, P Meera, B Altindag, R Chopra, E Perkins, S Paul, DR Scoles, ... MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018 | | 2018 |
BIOLOGICAL SCIENCES: Neuroscience, cell biology MTSS1/Src family kinase Dysregulation Underlies Multiple Inherited Ataxias AS Brown, P Meera, B Altindag, R Chopra, E Perkins, S Paul, DR Scoles, ... bioRxiv, 338046, 2018 | | 2018 |
Purkinje Neuron Atrophy in Spinocerebellar Ataxia Type 1 Represents a Compensatory Mechanism for Increased Membrane Excitability J Dell'Orco, A Wasserman, R Chopra, V Shakkottai ANNALS OF NEUROLOGY 76, S47-S47, 2014 | | 2014 |