Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS ET Chouchani, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, ... Nature 515 (7527), 431-435, 2014 | 2495 | 2014 |
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1331 | 2018 |
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat L Kazak, ET Chouchani, MP Jedrychowski, BK Erickson, K Shinoda, ... Cell 163 (3), 643-655, 2015 | 700 | 2015 |
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury ET Chouchani, VR Pell, AM James, LM Work, K Saeb-Parsy, C Frezza, ... Cell metabolism 23 (2), 254-263, 2016 | 684 | 2016 |
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I ET Chouchani, C Methner, SM Nadtochiy, A Logan, VR Pell, S Ding, ... Nature medicine 19 (6), 753-759, 2013 | 651 | 2013 |
New advances in adaptive thermogenesis: UCP1 and beyond ET Chouchani, L Kazak, BM Spiegelman Cell metabolism 29 (1), 27-37, 2019 | 601 | 2019 |
Accumulation of succinate controls activation of adipose tissue thermogenesis EL Mills, KA Pierce, MP Jedrychowski, R Garrity, S Winther, S Vidoni, ... Nature 560 (7716), 102-106, 2018 | 441 | 2018 |
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, ... Nature 532 (7597), 112-116, 2016 | 425 | 2016 |
Coupling Krebs cycle metabolites to signalling in immunity and cancer DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ... Nature metabolism 1 (1), 16-33, 2019 | 324 | 2019 |
Mitochondrial redox signalling at a glance Y Collins, ET Chouchani, AM James, KE Menger, HM Cochemé, ... Journal of cell science 125 (4), 801-806, 2012 | 313 | 2012 |
Metabolic adaptation and maladaptation in adipose tissue ET Chouchani, S Kajimura Nature metabolism 1 (2), 189-200, 2019 | 282 | 2019 |
A quantitative tissue-specific landscape of protein redox regulation during aging H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ... Cell 180 (5), 968-983. e24, 2020 | 276 | 2020 |
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity L Kazak, ET Chouchani, GZ Lu, MP Jedrychowski, CJ Bare, AI Mina, ... Cell metabolism 26 (4), 660-671. e3, 2017 | 261 | 2017 |
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury TA Prime, FH Blaikie, C Evans, SM Nadtochiy, AM James, CC Dahm, ... Proceedings of the National Academy of Sciences 106 (26), 10764-10769, 2009 | 241 | 2009 |
Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling AM Bertholet, L Kazak, ET Chouchani, MG Bogaczyńska, I Paranjpe, ... Cell metabolism 25 (4), 811-822. e4, 2017 | 221 | 2017 |
H+ transport is an integral function of the mitochondrial ADP/ATP carrier AM Bertholet, ET Chouchani, L Kazak, A Angelin, A Fedorenko, JZ Long, ... Nature 571 (7766), 515-520, 2019 | 209 | 2019 |
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction L Kazak, ET Chouchani, IG Stavrovskaya, GZ Lu, MP Jedrychowski, ... Proceedings of the National Academy of Sciences 114 (30), 7981-7986, 2017 | 172 | 2017 |
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses PK Langston, A Nambu, J Jung, M Shibata, HI Aksoylar, J Lei, P Xu, ... Nature immunology 20 (9), 1186-1195, 2019 | 169 | 2019 |
pH-gated succinate secretion regulates muscle remodeling in response to exercise A Reddy, LHM Bozi, OK Yaghi, EL Mills, H Xiao, HE Nicholson, ... Cell 183 (1), 62-75. e17, 2020 | 165 | 2020 |
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury VR Pell, ET Chouchani, C Frezza, MP Murphy, T Krieg Cardiovascular research 111 (2), 134-141, 2016 | 147 | 2016 |