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Madeleine Henley
Madeleine Henley
Scientist, Foghorn Therapeutics
在 mit.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Advances in targeting ‘undruggable’transcription factors with small molecules
MJ Henley, AN Koehler
Nature Reviews Drug Discovery 20 (9), 669-688, 2021
1912021
Unexpected Specificity within Dynamic Transcriptional Protein-Protein Complexes
MJ Henley, BM Linhares, BS Morgan, CA Fierke, T Cierpicki, A Mapp
Proceedings of the National Academy of Sciences 117 (44), 27346-27353, 2020
342020
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators
AR Henderson, MJ Henley, NJ Foster, AL Peiffer, MS Beyersdorf, ...
Proceedings of the National Academy of Sciences 115 (36), 8960-8965, 2018
312018
A dual-site inhibitor of CBP/p300 KIX is a selective and effective modulator of Myb
ST Joy, MJ Henley, SN De Salle, MS Beyersdorf, IW Vock, AJL Huldin, ...
Journal of the American Chemical Society 143 (37), 15056-15062, 2021
242021
Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P
BP Klemm, A Karasik, KJ Kaitany, A Shanmuganathan, MJ Henley, ...
Rna 23 (12), 1860-1873, 2017
222017
Drugging fuzzy complexes in transcription
BG Su, MJ Henley
Frontiers in Molecular Biosciences 8, 795743, 2021
152021
Unexpectedly Stable (Chlorocarbonyl)(N-ethoxycarbonylcarbamoyl) disulfane, and Related Compounds That Model the Zumach–Weiss–Kühle (ZWK) Reaction for Synthesis of 1, 2, 4 …
G Barany, D Britton, L Chen, RP Hammer, MJ Henley, AM Schrader, ...
The Journal of Organic Chemistry 80 (22), 11313-11321, 2015
52015
Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule
MJ Henley, SK Doyle, AN Koehler
Cell Chemical Biology 28 (1), 1-3, 2021
22021
Crystal structure of O-ethyl N-(ethoxycarbonyl) thiocarbamate
MJ Henley, AM Schrader, VG Young Jr, G Barany
Acta Crystallographica Section E: Crystallographic Communications 71 (10 …, 2015
22015
Garcinolic acid distinguishes between GACKIX domains and modulates interaction networks
ME Breen, ST Joy, OJ Baruti, MS Beyersdorf, MJ Henley, SN De Salle, ...
Chembiochem 24 (21), e202300439, 2023
12023
Crystal structures of (N-methyl-N-phenylamino)(N-methyl-N-phenylcarbamoyl) sulfide and the corresponding disulfane
MJ Henley, AL Schroll, VG Young Jr, G Barany
Acta Crystallographica Section E: Crystallographic Communications 71 (11 …, 2015
12015
Crystal structure of bis (N-methyl-N-phenylamino) trisulfane
G Barany, MJ Henley, LA Polski, AL Schroll, VG Young Jr
Acta Crystallographica Section E: Crystallographic Communications 71 (7 …, 2015
12015
Small molecule binders of the oncogenic fusion transcription factor PAX3-FOXO1
AN Koehler, S Doyle, B Leifer, M Henley, BW Schaefer, M Wachtel
US Patent 11,964,022, 2024
2024
Inhibition of CREB binding and function with a dual-targeting ligand
Y Liu, ST Joy, MJ Henley, A Croskey, JA Yates, SD Merajver, AK Mapp
Biochemistry 63 (1), 1-8, 2023
2023
Preparation, Characterization, and Mechanistic Considerations for 1, 1, 1-Tri (thioacetyl) ethane and 1, 1-Di (thioacetyl) ethene
ES Goebel, MJ Turcotte, MJ Henley, VG Young Jr, G Barany
The Journal of Organic Chemistry 88 (11), 7535-7538, 2023
2023
Mechanistic Insights Into the Zumach-Weiss-Kühle Synthesis of Dithiasuccinoyl (Dts)-Protected Amines
MJ Henley, MJ Barany, L Chen, RP Hammer, AM Schrader, VG Young Jr, ...
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