| InterPro in 2017—beyond protein family and domain annotations RD Finn, TK Attwood, PC Babbitt, A Bateman, P Bork, AJ Bridge, ... Nucleic acids research 45 (D1), D190-D199, 2017 | 1552 | 2017 |
| InterPro in 2019: improving coverage, classification and access to protein sequence annotations AL Mitchell, TK Attwood, PC Babbitt, M Blum, P Bork, A Bridge, SD Brown, ... Nucleic acids research 47 (D1), D351-D360, 2019 | 1488 | 2019 |
| A large-scale evaluation of computational protein function prediction P Radivojac, WT Clark, TR Oron, AM Schnoes, T Wittkop, A Sokolov, ... Nature methods 10 (3), 221-227, 2013 | 1048 | 2013 |
| Annotation error in public databases: misannotation of molecular function in enzyme superfamilies AM Schnoes, SD Brown, I Dodevski, PC Babbitt PLoS computational biology 5 (12), e1000605, 2009 | 802 | 2009 |
| Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies JA Gerlt, PC Babbitt Annual review of biochemistry 70 (1), 209-246, 2001 | 660 | 2001 |
| Using sequence similarity networks for visualization of relationships across diverse protein superfamilies HJ Atkinson, JH Morris, TE Ferrin, PC Babbitt PloS one 4 (2), e4345, 2009 | 470 | 2009 |
| Encyclopedia of computational chemistry PR Schleyer (No Title), 1998 | 467 | 1998 |
| The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the α-protons of carboxylic acids PC Babbitt, MS Hasson, JE Wedekind, DRJ Palmer, WC Barrett, GH Reed, ... Biochemistry 35 (51), 16489-16501, 1996 | 430 | 1996 |
| An expanded evaluation of protein function prediction methods shows an improvement in accuracy Y Jiang, TR Oron, WT Clark, AR Bankapur, D D’Andrea, R Lepore, ... Genome biology 17, 1-19, 2016 | 414 | 2016 |
| Understanding enzyme superfamilies: chemistry as the fundamental determinant in the evolution of new catalytic activities PC Babbitt, JA Gerlt Journal of Biological Chemistry 272 (49), 30591-30594, 1997 | 367 | 1997 |
| The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens N Zhou, Y Jiang, TR Bergquist, AJ Lee, BZ Kacsoh, AW Crocker, ... Genome biology 20, 1-23, 2019 | 359 | 2019 |
| Evolution of enzyme superfamilies ME Glasner, JA Gerlt, PC Babbitt Current opinion in chemical biology 10 (5), 492-497, 2006 | 284 | 2006 |
| BayGenomics: a resource of insertional mutations in mouse embryonic stem cells D Stryke, M Kawamoto, CC Huang, SJ Johns, LA King, CA Harper, ... Nucleic Acids Research 31 (1), 278-281, 2003 | 284 | 2003 |
| Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl: adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA … PC Babbitt, GL Kenyon, BM Martin, H Charest, M Slyvestre, JD Scholten, ... Biochemistry 31 (24), 5594-5604, 1992 | 274 | 1992 |
| The structure–function linkage database E Akiva, S Brown, DE Almonacid, AE Barber 2nd, AF Custer, MA Hicks, ... Nucleic acids research 42 (D1), D521-D530, 2014 | 247 | 2014 |
| Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity JA Gerlt, PC Babbitt, I Rayment Archives of biochemistry and biophysics 433 (1), 59-70, 2005 | 244 | 2005 |
| Evolutionary potential of (β/α) 8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily DMZ Schmidt, EC Mundorff, M Dojka, E Bermudez, JE Ness, ... Biochemistry 42 (28), 8387-8393, 2003 | 229 | 2003 |
| Can sequence determine function? JA Gerlt, PC Babbitt Genome biology 1, 1-10, 2000 | 221 | 2000 |
| Leveraging enzyme structure− function relationships for functional inference and experimental design: the structure− function linkage database SCH Pegg, SD Brown, S Ojha, J Seffernick, EC Meng, JH Morris, ... Biochemistry 45 (8), 2545-2555, 2006 | 198 | 2006 |
| A functionally diverse enzyme superfamily that abstracts the α protons of carboxylic acids PC Babbitt, GT Mrachko, MS Hasson, GW Huisman, R Kolter, D Ringe, ... Science 267 (5201), 1159-1161, 1995 | 197 | 1995 |
