A general approach to the asymmetric synthesis of unsaturated lipidic α-amino acids. The first synthesis of α-aminoarachidonic acid G Kokotos, JM Padron, T Martín, WA Gibbons, VS Martin The Journal of Organic Chemistry 63 (11), 3741-3744, 1998 | 127 | 1998 |
Enantiospecific synthesis of α-amino acid semialdehydes: a key step for the synthesis of unnatural unsaturated and saturated α-amino acids JM Padrón, G Kokotos, T Martín, T Markidis, WA Gibbons, VS Martín Tetrahedron: Asymmetry 9 (19), 3381-3394, 1998 | 121 | 1998 |
The multilayered postconfluent cell culture as a model for drug screening JM Padrón, CL van der Wilt, K Smid, E Smitskamp-Wilms, HHJ Backus, ... Critical Reviews in Oncology/Hematology 36 (2), 141-157, 2000 | 113 | 2000 |
Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol EL Bonifazi, C Ríos-Luci, LG León, G Burton, JM Padrón, RI Misico Bioorganic & Medicinal Chemistry 18 (7), 2621-2630, 2010 | 95 | 2010 |
Prins‐type synthesis and SAR study of cytotoxic alkyl chloro dihydropyrans PO Miranda, JM Padron, JI Padrón, J Villar, VS Martín ChemMedChem 1 (3), 323-329, 2006 | 88 | 2006 |
Enantioselective transport by a steroidal guanidinium receptor B Baragaña, AG Blackburn, P Breccia, AP Davis, J De Mendoza, ... Chemistry–A European Journal 8 (13), 2931-2936, 2002 | 85 | 2002 |
Folate depletion increases sensitivity of solid tumor cell lines to 5‐fluorouracil and antifolates HHJ Backus, HM Pinedo, D Wouters, JM Padron, N Molders, ... International Journal of Cancer 87 (6), 771-778, 2000 | 85 | 2000 |
Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines IC Guerrero, LS Andrés, LG León, RP Machín, JM Padrón, JG Luis, ... Journal of Natural Products 69 (12), 1803-1805, 2006 | 80 | 2006 |
Stereocontrolled synthesis of cyclic ethers by intramolecular hetero-Michael addition. 5. Synthesis of all diastereoisomers of 2,3,5,6-tetrasubstituted tetrahydropyrans JM Betancort, VS Martin, JM Padron, JM Palazon, MA Ramirez, MA Soler The Journal of Organic Chemistry 62 (14), 4570-4583, 1997 | 78 | 1997 |
Repurposing old drugs to fight multidrug resistant cancers J Dinić, T Efferth, AT García-Sosa, J Grahovac, JM Padrón, I Pajeva, ... Drug Resistance Updates 52, 100713, 2020 | 72 | 2020 |
Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand CM Santos, S Cabrera, C Ríos-Luci, JM Padrón, IL Solera, AG Quiroga, ... Dalton Transactions 42 (37), 13343-13348, 2013 | 72 | 2013 |
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents JM Roldán-Peña, D Alejandre-Ramos, Ó López, I Maya, I Lagunes, ... European Journal of Medicinal Chemistry 138, 761-773, 2017 | 70 | 2017 |
Catalytically generated ferrocene-containing guanidines as efficient precursors for new redox-active heterometallic platinum(II) complexes with anticancer activity D Nieto, S Bruña, AM González-Vadillo, J Perles, F Carrillo-Hermosilla, ... Organometallics 34 (22), 5407-5417, 2015 | 67 | 2015 |
Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines S Rudys, C Ríos-Luci, E Pérez-Roth, I Cikotiene, JM Padrón Bioorganic & Medicinal Chemistry Letters 20 (5), 1504-1506, 2010 | 65 | 2010 |
Hydroxyl alkyl ammonium Ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation DM Patel, MG Sharma, RM Vala, I Lagunes, A Puerta, JM Padrón, ... Bioorganic Chemistry 86, 137-150, 2019 | 64 | 2019 |
Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol CR Pungitore, LG León, C García, VS Martín, CE Tonn, JM Padrón Bioorganic & Medicinal Chemistry Letters 17 (5), 1332-1335, 2007 | 58 | 2007 |
Heterometallic platinum(II) compounds with β-aminoethylferrocenes: synthesis, electrochemical behaviour and anticancer activity D Nieto, AM González-Vadillo, S Bruña, CJ Pastor, C Ríos-Luci, LG León, ... Dalton Transactions 41 (2), 432-441, 2012 | 57 | 2012 |
Antiproliferative activity of withanolides against human breast cancer cell lines RP Machin, AS Veleiro, VE Nicotra, JC Oberti, J M. Padrón Journal of Natural Products 73 (5), 966-968, 2010 | 57 | 2010 |
Molecular simplification in bioactive molecules: formal synthesis of (+)-muconin FR Pinacho Crisóstomo, R Carrillo, LG León, T Martín, JM Padrón, ... The Journal of Organic Chemistry 71 (6), 2339-2345, 2006 | 54 | 2006 |
Antiproliferative and structure activity relationships of Amaryllidaceae alkaloids JC Cedrón, ÁG Ravelo, LG León, JM Padrón, A Estévez-Braun Molecules 20 (8), 13854-13863, 2015 | 53 | 2015 |