| Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials ES Newlands, MFG Stevens, SR Wedge, RT Wheelhouse, C Brock Cancer treatment reviews 23 (1), 35-61, 1997 | 1020 | 1997 |
| NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA BJ Denny, RT Wheelhouse, MFG Stevens, LLH Tsang, JA Slack Biochemistry 33 (31), 9045-9051, 1994 | 583 | 1994 |
| Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl) porphine with quadruplex DNA RT Wheelhouse, D Sun, H Han, FX Han, LH Hurley Journal of the American Chemical Society 120 (13), 3261-3262, 1998 | 572 | 1998 |
| Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells E Izbicka, RT Wheelhouse, E Raymond, KK Davidson, RA Lawrence, ... Cancer research 59 (3), 639-644, 1999 | 533 | 1999 |
| Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition F Xiaoguan Han, RT Wheelhouse, LH Hurley Journal of the American Chemical Society 121 (15), 3561-3570, 1999 | 448 | 1999 |
| Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition FX Han, RT Wheelhouse, LH Hurley Journal of the American Chemical Society 121 (15), 3561-3570, 1999 | 443 | 1999 |
| Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase DF Shi, RT Wheelhouse, D Sun, LH Hurley Journal of medicinal chemistry 44 (26), 4509-4523, 2001 | 351 | 2001 |
| G-quadruplexes as targets for drug design LH Hurley, RT Wheelhouse, D Sun, SM Kerwin, M Salazar, OY Fedoroff, ... Pharmacology & therapeutics 85 (3), 141-158, 2000 | 300 | 2000 |
| Glioblastoma multiforme therapy and mechanisms of resistance YP Ramirez, JL Weatherbee, RT Wheelhouse, AH Ross Pharmaceuticals 6 (12), 1475-1506, 2013 | 291 | 2013 |
| Antitumor Imidazotetrazines. 32.1 Synthesis of Novel Imidazotetrazinones and Related Bicyclic Heterocycles To Probe the Mode of Action of the Antitumor Drug Temozolomide AS Clark, B Deans, MFG Stevens, MJ Tisdale, RT Wheelhouse, BJ Denny, ... Journal of medicinal chemistry 38 (9), 1493-1504, 1995 | 167 | 1995 |
| Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate JL Holley, A Mather, RT Wheelhouse, PM Cullis, JA Hartley, JP Bingham, ... Cancer research 52 (15), 4190-4195, 1992 | 136 | 1992 |
| The medicinal chemistry of imidazotetrazine prodrugs CL Moody, RT Wheelhouse Pharmaceuticals 7 (7), 797-838, 2014 | 90 | 2014 |
| Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos E Izbicka, D Nishioka, V Marcell, E Raymond, KK Davidson, RA Lawrence, ... Anti-cancer drug design 14 (4), 355-365, 1999 | 90 | 1999 |
| In-vitro Cytotoxic Activities of the Major Bromophenols of the Red Alga Polysiphonia l anosa and Some Novel Synthetic Isomers NA Shoeib, MC Bibby, G Blunden, PA Linley, DJ Swaine, RT Wheelhouse, ... Journal of natural products 67 (9), 1445-1449, 2004 | 85 | 2004 |
| Mechanism for the Catalytic Activation of Ecteinascidin 743 and Its Subsequent Alkylation of Guanine N2. BM Moore, FC Seaman, RT Wheelhouse, LH Hurley Journal of the American Chemical Society 120 (38), 9975-9975, 1998 | 81 | 1998 |
| Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2 BM Moore, FC Seaman, RT Wheelhouse, LH Hurley Journal of the American Chemical Society 120 (10), 2490-2491, 1998 | 79 | 1998 |
| Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands SJ Allison, M Sadiq, E Baronou, PA Cooper, C Dunnill, NT Georgopoulos, ... Cancer letters 403, 98-107, 2017 | 66 | 2017 |
| Targeting of cytotoxic agents by polyamines: synthesis of a chlorambucil–spermidine conjugate GM Cohen, PM Cullis, JA Hartley, A Mather, MCR Symons, ... Journal of the Chemical Society, Chemical Communications, 298-300, 1992 | 51 | 1992 |
| A novel, high-yielding synthesis of meso-substituted porphyrins via the direct arylation of porphine DF Shi, RT Wheelhouse Tetrahedron letters 43 (51), 9341-9342, 2002 | 50 | 2002 |
| Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures RT Wheelhouse, SA Jennings, VA Phillips, D Pletsas, PM Murphy, ... Journal of medicinal chemistry 49 (17), 5187-5198, 2006 | 48 | 2006 |
RM PhillipsUniversity of Huddersfield在 hud.ac.uk 的电子邮件经过验证
