A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain J Wang, BJ Gu, CL Masters, YJ Wang Nature reviews neurology 13 (10), 612-623, 2017 | 829 | 2017 |
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor BJ Gu, W Zhang, RA Worthington, R Sluyter, P Dao-Ung, S Petrou, ... Journal of Biological Chemistry 276 (14), 11135-11142, 2001 | 412 | 2001 |
Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors BJ Gu, WY Zhang, LJ Bendall, IP Chessell, GN Buell, JS Wiley American Journal of Physiology-Cell Physiology 279 (4), C1189-C1197, 2000 | 273 | 2000 |
The human P2X7 receptor and its role in innate immunity JS Wiley, R Sluyter, BJ Gu, L Stokes, SJ Fuller Tissue antigens 78 (5), 321-332, 2011 | 251 | 2011 |
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region ML Smart, B Gu, RG Panchal, J Wiley, B Cromer, DA Williams, S Petrou Journal of Biological Chemistry 278 (10), 8853-8860, 2003 | 238 | 2003 |
An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor JS Wiley, LP Dao-Ung, C Li, AN Shemon, BJ Gu, ML Smart, SJ Fuller, ... Journal of Biological Chemistry 278 (19), 17108-17113, 2003 | 233 | 2003 |
Adenosine triphosphate–induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases B Gu, LJ Bendall, JS Wiley Blood, The Journal of the American Society of Hematology 92 (3), 946-951, 1998 | 231 | 1998 |
Two haplotypes of the P2X7 receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion L Stokes, SJ Fuller, R Sluyter, KK Skarratt, BJ Gu, JS Wiley The FASEB Journal 24 (8), 2916-2927, 2010 | 213 | 2010 |
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages AN Shemon, R Sluyter, SL Fernando, AL Clarke, LP Dao-Ung, KK Skarratt, ... Journal of Biological Chemistry 281 (4), 2079-2086, 2006 | 211 | 2006 |
A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study JS Wiley, LP Dao-Ung, BJ Gu, R Sluyter, AN Shemon, C Li, J Taper, ... The Lancet 359 (9312), 1114-1119, 2002 | 210 | 2002 |
An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor BJ Gu, R Sluyter, KK Skarratt, AN Shemon, LP Dao-Ung, SJ Fuller, ... Journal of Biological Chemistry 279 (30), 31287-31295, 2004 | 194 | 2004 |
Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor BJ Gu, JS Wiley Blood 107 (12), 4946-4953, 2006 | 188 | 2006 |
Genetics of the P2X7 receptor and human disease SJ Fuller, L Stokes, KK Skarratt, BJ Gu, JS Wiley Purinergic signalling 5, 257-262, 2009 | 159 | 2009 |
The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP BJ Gu, BM Saunders, C Jursik, JS Wiley Blood, The Journal of the American Society of Hematology 115 (8), 1621-1631, 2010 | 132 | 2010 |
P2X7 is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP BJ Gu, BM Saunders, S Petrou, JS Wiley The Journal of Immunology 187 (5), 2365-2375, 2011 | 112 | 2011 |
Extracellular ATP dissociates nonmuscle myosin from P2X7 complex: this dissociation regulates P2X7 pore formation BJ Gu, C Rathsam, L Stokes, AB McGeachie, JS Wiley American Journal of Physiology-Cell Physiology 297 (2), C430-C439, 2009 | 106 | 2009 |
A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age‐related macular degeneration BJ Gu, PN Baird, KA Vessey, KK Skarratt, EL Fletcher, SJ Fuller, ... The FASEB Journal 27 (4), 1479-1487, 2013 | 84 | 2013 |
A 5′ intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population KK Skarratt, SJ Fuller, R Sluyter, LP Dao-Ung, BJ Gu, JS Wiley FEBS letters 579 (12), 2675-2678, 2005 | 84 | 2005 |
Point mutations confer loss of ATP-induced human P2X7 receptor function RA Worthington, ML Smart, BJ Gu, DA Williams, S Petrou, JS Wiley, ... FEBS letters 512 (1-3), 43-46, 2002 | 83 | 2002 |
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis BJ Gu, J Field, S Dutertre, A Ou, TJ Kilpatrick, J Lechner-Scott, R Scott, ... Human molecular genetics 24 (19), 5644-5654, 2015 | 72 | 2015 |