| Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation E Dunny, W Doherty, P Evans, JPG Malthouse, D Nolan, AJS Knox Journal of Medicinal Chemistry 56 (17), 6638-6650, 2013 | 114 | 2013 |
| Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects M Carr, LM Greene, AJS Knox, DG Lloyd, DM Zisterer, MJ Meegan European journal of medicinal chemistry 45 (12), 5752-5766, 2010 | 90 | 2010 |
| Considerations in compound database preparation “Hidden” impact on virtual screening results AJS Knox, MJ Meegan, G Carta, DG Lloyd Journal of chemical information and modeling 45 (6), 1908-1919, 2005 | 81 | 2005 |
| Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries M Hintersteiner, G Ambrus, J Bednenko, M Schmied, AJS Knox, ... ACS chemical biology 5 (10), 967-979, 2010 | 70 | 2010 |
| Oncology exploration: charting cancer medicinal chemistry space DG Lloyd, G Golfis, AJS Knox, D Fayne, MJ Meegan, TI Oprea Drug discovery today 11 (3-4), 149-159, 2006 | 68 | 2006 |
| Unbiasing scoring functions: a new normalization and rescoring strategy G Carta, AJS Knox, DG Lloyd Journal of chemical information and modeling 47 (4), 1564-1571, 2007 | 63 | 2007 |
| Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2 D Dinour, NK Gray, L Ganon, AJS Knox, H Shalev, BA Sela, S Campbell, ... Nephrology dialysis transplantation 27 (3), 1035-1041, 2012 | 61 | 2012 |
| Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators I Barrett, MJ Meegan, RB Hughes, M Carr, AJS Knox, N Artemenko, ... Bioorganic & medicinal chemistry 16 (21), 9554-9573, 2008 | 58 | 2008 |
| β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand NM O’Boyle, JK Pollock, M Carr, AJS Knox, SM Nathwani, S Wang, ... Journal of Medicinal Chemistry 57 (22), 9370-9382, 2014 | 53 | 2014 |
| Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe NM O’Boyle, M Carr, LM Greene, NO Keely, AJS Knox, T McCabe, ... European journal of medicinal chemistry 46 (9), 4595-4607, 2011 | 51 | 2011 |
| Target specific virtual screening: optimization of an estrogen receptor screening platform AJS Knox, MJ Meegan, V Sobolev, D Frost, DM Zisterer, DC Williams, ... Journal of medicinal chemistry 50 (22), 5301-5310, 2007 | 47 | 2007 |
| Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin AJS Knox, T Price, M Pawlak, G Golfis, CT Flood, D Fayne, DC Williams, ... Journal of medicinal chemistry 52 (8), 2177-2180, 2009 | 46 | 2009 |
| Estrogen receptors: molecular interactions, virtual screening and future prospects AJS Knox, MJ Meegan, DG Lloyd Current Topics in Medicinal Chemistry 6 (3), 217-243, 2006 | 42 | 2006 |
| Lead optimization of benzoxepin-type selective estrogen receptor (ER) modulators and downregulators with subtype-specific ERα and ERβ activity NM O’Boyle, I Barrett, LM Greene, M Carr, D Fayne, B Twamley, AJS Knox, ... Journal of medicinal chemistry 61 (2), 514-534, 2018 | 38 | 2018 |
| Synthesis and serotonin transporter activity of 1, 3-bis (aryl)-2-nitro-1-propenes as a new class of anticancer agents YM McNamara, SM Cloonan, AJS Knox, JJ Keating, SG Butler, GH Peters, ... Bioorganic & medicinal chemistry 19 (3), 1328-1348, 2011 | 32 | 2011 |
| Modulating the blood–brain barrier: a comprehensive review R Whelan, GC Hargaden, AJS Knox Pharmaceutics 13 (11), 1980, 2021 | 31 | 2021 |
| Microfluidics in haemostasis: a review H Jigar Panchal, NJ Kent, AJS Knox, LF Harris Molecules 25 (4), 833, 2020 | 30 | 2020 |
| Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones KAJS Doherty W, James J, Evans P, Martin L, Adler N, Nolan D Organic and Biomolecular Chemistry 12, 7561-7571, 2014 | 30 | 2014 |
| Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90 NM O’Boyle, AJS Knox, TT Price, DC Williams, DM Zisterer, DG Lloyd, ... Bioorganic & medicinal chemistry 19 (20), 6055-6068, 2011 | 29 | 2011 |
| Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents SM Cloonan, JJ Keating, SG Butler, AJS Knox, AM Jørgensen, GH Peters, ... European journal of medicinal chemistry 44 (12), 4862-4888, 2009 | 28 | 2009 |
Mary MeeganTrinity College Dublin在 tcd.ie 的电子邮件经过验证
