The Catharanthus alkaloids: pharmacognosy and biotechnology DI Jacobs, W Snoeijer, D Hallard, R Verpoorte Current medicinal chemistry 11 (5), 607-628, 2004 | 976 | 2004 |
Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology M Wang, RJ Lamers, HA Korthout, JH van Nesselrooij, RF Witkamp, ... Phytother Res 19, 173-182, 2005 | 406 | 2005 |
Geraniol 10‐hydroxylase1, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis G Collu, N Unver, AMG Peltenburg-Looman, R van der Heijden, ... FEBS letters 508 (2), 215-220, 2001 | 400 | 2001 |
Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals R Verpoorte, R van der Heijden, HJG Ten Hoopen, J Memelink Biotechnology letters 21, 467-479, 1999 | 392 | 1999 |
The role of analytical sciences in medical systems biology J van der Greef, P Stroobant, R van der Heijden Current opinion in chemical biology 8 (5), 559-565, 2004 | 336 | 2004 |
Cell and tissue cultures of Catharanthus roseus: A literature survey: II. Updating from 1988 to 1993 PRH Moreno, R van der Heijden, R Verpoorte Plant cell, tissue and organ culture 42, 1-25, 1995 | 302 | 1995 |
Engineering the plant cell factory for secondary metabolite production R Verpoorte, R van der Heijden, J Memelink Transgenic research 9, 323-343, 2000 | 298 | 2000 |
LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery [S] J van Smeden, L Hoppel, R van der Heijden, T Hankemeier, RJ Vreeken, ... Journal of lipid research 52 (6), 1211-1221, 2011 | 290 | 2011 |
Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus C Canel, MI Lopes-Cardoso, S Whitmer, L van der Fits, G Pasquali, ... Planta 205, 414-419, 1998 | 280 | 1998 |
Analytical strategies in lipidomics and applications in disease biomarker discovery C Hu, R van der Heijden, M Wang, J van der Greef, T Hankemeier, G Xu Journal of Chromatography B 877 (26), 2836-2846, 2009 | 272 | 2009 |
High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural … K Ingkaninan, CM De Best, R Van Der Heijden, AJP Hofte, B Karabatak, ... Journal of Chromatography A 872 (1-2), 61-73, 2000 | 264 | 2000 |
Molecular cloning and analysis of strictosidine β-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus A Geerlings, MML Ibanez, J Memelink, R van der Heijden, R Verpoorte Journal of Biological Chemistry 275 (5), 3051-3056, 2000 | 225 | 2000 |
The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture A Contin, R van der Heijden, AWM Lefeber, R Verpoorte FEBS letters 434 (3), 413-416, 1998 | 225 | 1998 |
Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function AC Ramos-Valdivia, R van der Heijden, R Verpoorte Natural product reports 14 (6), 591-603, 1997 | 214 | 1997 |
RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model C Hu, J Van Dommelen, R Van Der Heijden, G Spijksma, TH Reijmers, ... Journal of proteome research 7 (11), 4982-4991, 2008 | 213 | 2008 |
Cell and tissue cultures ofCatharanthus roseus (L.) G. Don: a literature survey R Van Der Heijden, R Verpoorte, HJG Ten Hoopen Plant cell, tissue and organ culture 18, 231-280, 1989 | 192 | 1989 |
Plant cell biotechnology for the production of alkaloids: present status and prospects R Verpoorte, R Van der Heijden, J Schripsema, JHC Hoge, ... Journal of Natural products 56 (2), 186-207, 1993 | 188 | 1993 |
Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus PRH Moreno, R Van der Heijden, R Verpoorte Plant Cell Reports 12, 702-705, 1993 | 183 | 1993 |
Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study) FM Van der Kloet, FWA Tempels, N Ismail, R Van der Heijden, PT Kasper, ... Metabolomics 8, 109-119, 2012 | 182 | 2012 |
Biosynthesis of anthraquinones in cell cultures of the Rubiaceae YS Han, R Van der Heijden, R Verpoorte Plant Cell, Tissue and Organ Culture 67, 201-220, 2001 | 181 | 2001 |