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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake ÖH Yilmaz, P Katajisto, DW Lamming, Y Gültekin, KE Bauer-Rowe, ... Nature 486 (7404), 490-495, 2012 | 774 | 2012 |
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness P Katajisto, J Döhla, CL Chaffer, N Pentinmikko, N Marjanovic, S Iqbal, ... Science 348 (6232), 340-343, 2015 | 539 | 2015 |
Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging MM Mihaylova, CW Cheng, AQ Cao, S Tripathi, MD Mana, ... Cell stem cell 22 (5), 769-778. e4, 2018 | 346 | 2018 |
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis J Roper, T Tammela, NM Cetinbas, A Akkad, A Roghanian, S Rickelt, ... Nature biotechnology 35 (6), 569-576, 2017 | 322 | 2017 |
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma T Tammela, FJ Sanchez-Rivera, NM Cetinbas, K Wu, NS Joshi, ... Nature 545 (7654), 355-359, 2017 | 319 | 2017 |
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells D Balboa, T Barsby, V Lithovius, J Saarimäki-Vire, M Omar-Hmeadi, ... Nature biotechnology 40 (7), 1042-1055, 2022 | 206 | 2022 |
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium N Pentinmikko, S Iqbal, M Mana, S Andersson, AB Cognetta III, RM Suciu, ... Nature 571 (7765), 398-402, 2019 | 201 | 2019 |
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer DJ Flanagan, N Pentinmikko, K Luopajärvi, NJ Willis, K Gilroy, AP Raven, ... Nature 594 (7863), 430-435, 2021 | 150 | 2021 |
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis P Katajisto, K Vaahtomeri, N Ekman, E Ventelä, A Ristimäki, N Bardeesy, ... Nature genetics 40 (4), 455-459, 2008 | 149 | 2008 |
The LKB1 tumor suppressor kinase in human disease P Katajisto, T Vallenius, K Vaahtomeri, N Ekman, L Udd, M Tiainen, ... Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1775 (1), 63-75, 2007 | 141 | 2007 |
Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan DW Lamming, MM Mihaylova, P Katajisto, EL Baar, OH Yilmaz, ... Aging cell 13 (5), 911-917, 2014 | 139 | 2014 |
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity JI Partanen, TA Tervonen, M Myllynen, E Lind, M Imai, P Katajisto, ... Proceedings of the National Academy of Sciences 109 (7), E388-E397, 2012 | 114 | 2012 |
Suppression of Peutz—Jeghers polyposis by inhibition of cyclooxygenase-2 L Udd, P Katajisto, DJ Rossi, A Lepistö, AM Lahesmaa, A Ylikorkala, ... Gastroenterology 127 (4), 1030-1037, 2004 | 105 | 2004 |
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11–JAK/STAT3 pathway S Ollila, E Domènech-Moreno, K Laajanen, IPL Wong, S Tripathi, ... The Journal of clinical investigation 128 (1), 402-414, 2018 | 64 | 2018 |
Metabolic determination of cell fate through selective inheritance of mitochondria J Döhla, E Kuuluvainen, N Gebert, A Amaral, JI Englund, ... Nature cell biology 24 (2), 148-154, 2022 | 59 | 2022 |
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes L Hases, R Indukuri, M Birgersson, T Nguyen-Vu, R Lozano, A Saxena, ... Cancer letters 492, 54-62, 2020 | 56 | 2020 |
LKB1 in endothelial cells is required for angiogenesis and TGFβ-mediated vascular smooth muscle cell recruitment A Londesborough, K Vaahtomeri, M Tiainen, P Katajisto, N Ekman, ... Oxford University Press for The Company of Biologists Limited 135 (13), 2331 …, 2008 | 51 | 2008 |
Lkb1 is required for TGFβ-mediated myofibroblast differentiation K Vaahtomeri, E Ventelä, K Laajanen, P Katajisto, PJ Wipff, B Hinz, ... Journal of cell science 121 (21), 3531-3540, 2008 | 48 | 2008 |
Retrograde movements determine effective stem cell numbers in the intestine M Azkanaz, B Corominas-Murtra, SIJ Ellenbroek, L Bruens, AT Webb, ... Nature 607 (7919), 548-554, 2022 | 43 | 2022 |