Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo OA Andreev, AD Dupuy, M Segala, S Sandugu, DA Serra, CO Chichester, ... Proceedings of the National Academy of Sciences 104 (19), 7893-7898, 2007 | 345 | 2007 |
Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix YK Reshetnyak, OA Andreev, U Lehnert, DM Engelman Proceedings of the National Academy of Sciences 103 (17), 6460-6465, 2006 | 271 | 2006 |
A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers YK Reshetnyak, M Segala, OA Andreev, DM Engelman Biophysical journal 93 (7), 2363-2372, 2007 | 227 | 2007 |
A novel technology for the imaging of acidic prostate tumors by positron emission tomography AL Vavere, GB Biddlecombe, WM Spees, JR Garbow, D Wijesinghe, ... Cancer research 69 (10), 4510-4516, 2009 | 216 | 2009 |
Family of pH (low) insertion peptides for tumor targeting D Weerakkody, A Moshnikova, MS Thakur, V Moshnikova, J Daniels, ... Proceedings of the National Academy of Sciences 110 (15), 5834-5839, 2013 | 214 | 2013 |
Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane YK Reshetnyak, OA Andreev, M Segala, VS Markin, DM Engelman Proceedings of the National Academy of Sciences 105 (40), 15340-15345, 2008 | 200 | 2008 |
Probe for the measurement of cell surface pH in vivo and ex vivo M Anderson, A Moshnikova, DM Engelman, YK Reshetnyak, OA Andreev Proceedings of the National Academy of Sciences 113 (29), 8177-8181, 2016 | 195 | 2016 |
pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path OA Andreev, AG Karabadzhak, D Weerakkody, GO Andreev, ... Proceedings of the National Academy of Sciences 107 (9), 4081-4086, 2010 | 179 | 2010 |
pHLIP peptide targets nanogold particles to tumors L Yao, J Daniels, A Moshnikova, S Kuznetsov, A Ahmed, DM Engelman, ... Proceedings of the National Academy of Sciences 110 (2), 465-470, 2013 | 174 | 2013 |
pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation M An, D Wijesinghe, OA Andreev, YK Reshetnyak, DM Engelman Proceedings of the National Academy of Sciences 107 (47), 20246-20250, 2010 | 163 | 2010 |
pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents OA Andreev, DM Engelman, YK Reshetnyak Molecular membrane biology 27 (7), 341-352, 2010 | 151 | 2010 |
Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP YK Reshetnyak, L Yao, S Zheng, S Kuznetsov, DM Engelman, ... Molecular imaging and biology 13, 1146-1156, 2011 | 118 | 2011 |
Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors LC Wyatt, A Moshnikova, T Crawford, DM Engelman, OA Andreev, ... Proceedings of the National Academy of Sciences 115 (12), E2811-E2818, 2018 | 111 | 2018 |
Applications of pHLIP technology for cancer imaging and therapy LC Wyatt, JS Lewis, OA Andreev, YK Reshetnyak, DM Engelman Trends in Biotechnology 35 (7), 653-664, 2017 | 111 | 2017 |
Targeting diseased tissues by pHLIP insertion at low cell surface pH OA Andreev, DM Engelman, YK Reshetnyak Frontiers in physiology 5, 97, 2014 | 106 | 2014 |
T-cells produce acidic niches in lymph nodes to suppress their own effector functions H Wu, V Estrella, M Beatty, D Abrahams, A El-Kenawi, S Russell, ... Nature communications 11 (1), 4113, 2020 | 105 | 2020 |
pHLIP®-mediated delivery of PEGylated liposomes to cancer cells L Yao, J Daniels, D Wijesinghe, OA Andreev, YK Reshetnyak Journal of Controlled Release 167 (3), 228-237, 2013 | 102 | 2013 |
Enhancement of radiation effect on cancer cells by gold-pHLIP MP Antosh, DD Wijesinghe, S Shrestha, R Lanou, YH Huang, ... Proceedings of the National Academy of Sciences 112 (17), 5372-5376, 2015 | 94 | 2015 |
Targeting pancreatic ductal adenocarcinoma acidic microenvironment Z Cruz-Monserrate, CL Roland, D Deng, T Arumugam, A Moshnikova, ... Scientific reports 4 (1), 4410, 2014 | 92 | 2014 |
pH (low) insertion peptide (pHLIP) targets ischemic myocardium EA Sosunov, EP Anyukhovsky, AA Sosunov, A Moshnikova, D Wijesinghe, ... Proceedings of the National Academy of Sciences 110 (1), 82-86, 2013 | 85 | 2013 |