Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells ODK Maddocks, CR Berkers, SM Mason, L Zheng, K Blyth, E Gottlieb, ... Nature 493 (7433), 542-546, 2013 | 966 | 2013 |
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress ZT Schug, B Peck, DT Jones, Q Zhang, S Grosskurth, IS Alam, ... Cancer cell 27 (1), 57-71, 2015 | 723 | 2015 |
The RUNX genes: gain or loss of function in cancer K Blyth, ER Cameron, JC Neil Nature Reviews Cancer 5 (5), 376-387, 2005 | 541 | 2005 |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation ODK Maddocks, D Athineos, EC Cheung, P Lee, T Zhang, ... Nature 544 (7650), 372-376, 2017 | 524 | 2017 |
Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death G Ichim, J Lopez, SU Ahmed, N Muthalagu, E Giampazolias, ME Delgado, ... Molecular cell 57 (5), 860-872, 2015 | 412 | 2015 |
Improving the metabolic fidelity of cancer models with a physiological cell culture medium J Vande Voorde, T Ackermann, N Pfetzer, D Sumpton, G Mackay, G Kalna, ... Science advances 5 (1), eaau7314, 2019 | 317 | 2019 |
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis S Cardaci, L Zheng, G MacKay, NJF Van den Broek, ED MacKenzie, ... Nature cell biology 17 (10), 1317-1326, 2015 | 281 | 2015 |
Fumarate induces redox-dependent senescence by modifying glutathione metabolism L Zheng, S Cardaci, L Jerby, ED MacKenzie, M Sciacovelli, TI Johnson, ... Nature communications 6 (1), 6001, 2015 | 278 | 2015 |
Proviral insertions induce the expression of bone-specific isoforms of PEBP2αA (CBFA1): Evidence for a new myc collaborating oncogene M Stewart, A Terry, M Hu, M O’hara, K Blyth, E Baxter, E Cameron, ... Proceedings of the National Academy of Sciences 94 (16), 8646-8651, 1997 | 258 | 1997 |
Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation V Bulusu, S Tumanov, E Michalopoulou, NJ van den Broek, G MacKay, ... Cell reports 18 (3), 647-658, 2017 | 235 | 2017 |
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency E Giampazolias, B Zunino, S Dhayade, F Bock, C Cloix, K Cao, A Roca, ... Nature cell biology 19 (9), 1116-1129, 2017 | 224 | 2017 |
In vivo models in breast cancer research: progress, challenges and future directions I Holen, V Speirs, B Morrissey, K Blyth Disease models & mechanisms 10 (4), 359-371, 2017 | 213 | 2017 |
X-SCID transgene leukaemogenicity AJ Thrasher, HB Gaspar, C Baum, U Modlich, A Schambach, F Candotti, ... Nature 443 (7109), E5-E6, 2006 | 203 | 2006 |
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium SE Reid, EJ Kay, LJ Neilson, AT Henze, J Serneels, EJ McGhee, ... The EMBO journal 36 (16), 2373-2389, 2017 | 202 | 2017 |
TIGAR is required for efficient intestinal regeneration and tumorigenesis EC Cheung, D Athineos, P Lee, RA Ridgway, W Lambie, C Nixon, ... Developmental cell 25 (5), 463-477, 2013 | 195 | 2013 |
CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high-grade serous carcinoma J Walton, J Blagih, D Ennis, E Leung, S Dowson, M Farquharson, ... Cancer research 76 (20), 6118-6129, 2016 | 193 | 2016 |
Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer EC Cheung, GM DeNicola, C Nixon, K Blyth, CF Labuschagne, ... Cancer cell 37 (2), 168-182. e4, 2020 | 192 | 2020 |
N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods X Yu, T Zech, L McDonald, EG Gonzalez, A Li, I Macpherson, JP Schwarz, ... Journal of cell biology 199 (3), 527-544, 2012 | 189 | 2012 |
MCL-1 is a prognostic indicator and drug target in breast cancer KJ Campbell, S Dhayade, N Ferrari, AH Sims, E Johnson, SM Mason, ... Cell death & disease 9 (2), 19, 2018 | 185 | 2018 |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ... Nature communications 12 (1), 366, 2021 | 177 | 2021 |