| Discovery and structure–activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions A Murza, X Sainsily, D Coquerel, J Côté, P Marx, É Besserer-Offroy, ... Journal of medicinal chemistry 59 (7), 2962-2972, 2016 | 135 | 2016 |
| Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties M Demeule, N Beaudet, A Régina, É Besserer-Offroy, A Murza, ... The Journal of clinical investigation 124 (3), 1199-1213, 2014 | 121 | 2014 |
| Elucidation of the structure–activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability A Murza, A Parent, E Besserer‐Offroy, H Tremblay, F Karadereye, ... ChemMedChem 7 (2), 318-325, 2012 | 112 | 2012 |
| Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs A Luginina, A Gusach, E Marin, A Mishin, R Brouillette, P Popov, ... Science advances 5 (10), eaax2518, 2019 | 81 | 2019 |
| Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors A Gusach, A Luginina, E Marin, RL Brouillette, É Besserer-Offroy, ... Nature communications 10 (1), 5573, 2019 | 66 | 2019 |
| The signaling signature of the neurotensin type 1 receptor with endogenous ligands É Besserer-Offroy, RL Brouillette, S Lavenus, U Froehlich, A Brumwell, ... European journal of pharmacology 805, 1-13, 2017 | 65 | 2017 |
| C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action A Murza, E Besserer-Offroy, J Cote, P Berube, JM Longpre, R Dumaine, ... Journal of medicinal chemistry 58 (5), 2431-2440, 2015 | 57 | 2015 |
| Synthesis, in vitro and in vivo characterization of (L)-(trimethylsilyl) alanine containing neurotensin analogues R Fanelli, É Besserer-Offroy, A René, J Côté, P Tétrault, ... Journal of Medicinal Chemistry, 2015 | 38* | 2015 |
| Apelin-13 regulates vasopressin-induced aquaporin-2 expression and trafficking in kidney collecting duct cells C Boulkeroua, H Ayari, T Khalfaoui, M Lafrance, É Besserer-Offroy, ... Cell Physiol Biochem 53 (4), 687-700, 2019 | 31 | 2019 |
| Structure–activity relationship of novel macrocyclic biased apelin receptor agonists A Murza, X Sainsily, J Côté, L Bruneau-Cossette, É Besserer-Offroy, ... Organic & biomolecular chemistry 15 (2), 449-458, 2017 | 31 | 2017 |
| The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment É Besserer-Offroy, P Bérubé, J Côté, A Murza, JM Longpré, R Dumaine, ... Pharmacological research 131, 7-16, 2018 | 30 | 2018 |
| Structural optimization and characterization of potent analgesic macrocyclic analogues of neurotensin (8–13) M Sousbie, M Vivancos, RL Brouillette, É Besserer-Offroy, JM Longpre, ... Journal of Medicinal Chemistry 61 (16), 7103-7115, 2018 | 29 | 2018 |
| Design, synthesis, and biological evaluation of CXCR4 ligands CE Mona, É Besserer-Offroy, J Cabana, R Leduc, P Lavigne, N Heveker, ... Organic & Biomolecular Chemistry 14 (43), 10298-10311, 2016 | 27 | 2016 |
| Structure-based virtual screening of ultra-large library yields potent antagonists for a lipid GPCR AA Sadybekov, RL Brouillette, E Marin, AV Sadybekov, A Luginina, ... Biomolecules 10 (12), 1634, 2020 | 25 | 2020 |
| Use of molecular modeling to design selective NTS2 neurotensin analogues R Fanelli, N Floquet, E Besserer-Offroy, B Delort, M Vivancos, JM Longpre, ... Journal of Medicinal Chemistry 60 (8), 3303-3313, 2017 | 22 | 2017 |
| Structural insights on ligand recognition at the human leukotriene B4 receptor 1 N Michaelian, A Sadybekov, É Besserer-Offroy, GW Han, ... Nature communications 12 (1), 2971, 2021 | 17 | 2021 |
| Stereoselective Synthesis of β‐(5‐Arylthiazolyl) α‐Amino Acids and Use in Neurotensin Analogues D Hapău, E Rémond, R Fanelli, M Vivancos, A René, J Côté, ... European Journal of Organic Chemistry 2016 (5), 1017-1024, 2016 | 17* | 2016 |
| Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain RL Brouillette, É Besserer-Offroy, CE Mona, M Chartier, S Lavenus, ... Pharmacological research 155, 104750, 2020 | 15 | 2020 |
| In search of the optimal macrocyclization site for neurotensin M Sousbie, E Besserer-Offroy, RL Brouillette, JM Longpré, R Leduc, ... ACS Medicinal Chemistry Letters 9 (3), 227-232, 2018 | 15 | 2018 |
| Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog P Tétreault, É Besserer-Offroy, R Brouillette, A René, A Murza, R Fanelli, ... European Journal of Pharmacology, 173174, 2020 | 11 | 2020 |
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