| ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association … Writing Committee Members, SA Hunt, WT Abraham, MH Chin, ... circulation 112 (12), e154-e235, 2005 | 9831* | 2005 |
| Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial MA Pfeffer, E Braunwald, LA Moyé, L Basta, EJ Brown Jr, TE Cuddy, ... New England journal of medicine 327 (10), 669-677, 1992 | 7632 | 1992 |
| Angiotensin–neprilysin inhibition versus enalapril in heart failure JJV McMurray, M Packer, AS Desai, J Gong, MP Lefkowitz, AR Rizkala, ... New England Journal of Medicine 371 (11), 993-1004, 2014 | 7388* | 2014 |
| Cardiac resynchronization in chronic heart failure WT Abraham, WG Fisher, AL Smith, DB Delurgio, AR Leon, E Loh, ... New England Journal of Medicine 346 (24), 1845-1853, 2002 | 6503 | 2002 |
| The effect of carvedilol on morbidity and mortality in patients with chronic heart failure M Packer, MR Bristow, JN Cohn, WS Colucci, MB Fowler, EM Gilbert, ... New England Journal of Medicine 334 (21), 1349-1355, 1996 | 6230 | 1996 |
| Effect of carvedilol on survival in severe chronic heart failure M Packer, AJS Coats, MB Fowler, HA Katus, H Krum, P Mohacsi, ... New England Journal of Medicine 344 (22), 1651-1658, 2001 | 4719 | 2001 |
| Cardiovascular and renal outcomes with empagliflozin in heart failure M Packer, SD Anker, J Butler, G Filippatos, SJ Pocock, P Carson, ... New England Journal of Medicine 383 (15), 1413-1424, 2020 | 4250 | 2020 |
| Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy S Pattingre, A Tassa, X Qu, R Garuti, XH Liang, N Mizushima, M Packer, ... Cell 122 (6), 927-939, 2005 | 4181 | 2005 |
| Elevated circulating levels of tumor necrosis factor in severe chronic heart failure B Levine, J Kalman, L Mayer, HM Fillit, M Packer New England Journal of Medicine 323 (4), 236-241, 1990 | 3531 | 1990 |
| Empagliflozin in heart failure with a preserved ejection fraction SD Anker, J Butler, G Filippatos, JP Ferreira, E Bocchi, M Böhm, ... New England Journal of Medicine 385 (16), 1451-1461, 2021 | 3299 | 2021 |
| Spironolactone for heart failure with preserved ejection fraction et al Pitt B, Pfeffer MA, Assmann SF N Engl J Med 370 (15), 1383-92, 2014 | 2741* | 2014 |
| Effect of oral milrinone on mortality in severe chronic heart failure M Packer, JR Carver, RJ Rodeheffer, RJ Ivanhoe, R DiBianco, SM Zeldis, ... New England Journal of Medicine 325 (21), 1468-1475, 1991 | 2729 | 1991 |
| The Seattle Heart Failure Model: prediction of survival in heart failure WC Levy, D Mozaffarian, DT Linker, SC Sutradhar, SD Anker, AB Cropp, ... Circulation 113 (11), 1424-1433, 2006 | 2412 | 2006 |
| Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction SD Solomon, JJV McMurray, IS Anand, J Ge, CSP Lam, AP Maggioni, ... New England Journal of Medicine 381 (17), 1609-1620, 2019 | 1942 | 2019 |
| Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-α, in patients with moderate-to-severe heart … ES Chung, M Packer, KH Lo, AA Fasanmade, JT Willerson Circulation 107 (25), 3133-3140, 2003 | 1885 | 2003 |
| Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure M Packer, PA Poole-Wilson, PW Armstrong, JGF Cleland, JD Horowitz, ... Circulation 100 (23), 2312-2318, 1999 | 1811 | 1999 |
| Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study M Packer, MB Fowler, EB Roecker, AJS Coats, HA Katus, H Krum, ... Circulation 106 (17), 2194-2199, 2002 | 1789 | 2002 |
| Effect of amlodipine on morbidity and mortality in severe chronic heart failure M Packer, CM O'Connor, JK Ghali, ML Pressler, PE Carson, RN Belkin, ... New England Journal of Medicine 335 (15), 1107-1114, 1996 | 1571 | 1996 |
| The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure M Packer Journal of the American College of Cardiology 20 (1), 248-254, 1992 | 1525 | 1992 |
| Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL) DL Mann, JJV McMurray, M Packer, K Swedberg, JS Borer, WS Colucci, ... Circulation 109 (13), 1594-1602, 2004 | 1498 | 2004 |
