Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans TM Wilkinson, CKF Li, CSC Chui, AKY Huang, M Perkins, JC Liebner, ... Nature medicine 18 (2), 274-280, 2012 | 1072 | 2012 |
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations D Mayhew, N Devos, C Lambert, JR Brown, SC Clarke, VL Kim, ... Thorax 73 (5), 422-430, 2018 | 264 | 2018 |
Innate and adaptive T cells in asthmatic patients: relationship to severity and disease mechanisms TSC Hinks, X Zhou, KJ Staples, BD Dimitrov, A Manta, T Petrossian, ... Journal of allergy and clinical immunology 136 (2), 323-333, 2015 | 220 | 2015 |
IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3 KJ Staples, T Smallie, LM Williams, A Foey, B Burke, BMJ Foxwell, ... The Journal of Immunology 178 (8), 4779-4785, 2007 | 212 | 2007 |
A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD TMA Wilkinson, E Aris, S Bourne, SC Clarke, M Peeters, TG Pascal, ... Thorax 72 (10), 919-927, 2017 | 194 | 2017 |
Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17 KJ Staples, TSC Hinks, JA Ward, V Gunn, C Smith, R Djukanović Journal of Allergy and Clinical Immunology 130 (6), 1404-1412. e7, 2012 | 145 | 2012 |
A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion SM Newton, RJ Smith, KA Wilkinson, MP Nicol, NJ Garton, KJ Staples, ... Proceedings of the National Academy of Sciences 103 (42), 15594-15598, 2006 | 143 | 2006 |
Dysregulation of Antiviral Function of CD8+ T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis RT McKendry, CM Spalluto, H Burke, B Nicholas, D Cellura, ... American journal of respiratory and critical care medicine 193 (6), 642-651, 2016 | 136 | 2016 |
IL‐1β‐dependent activation of NF‐κB mediates PGE2 release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase MC Catley, JE Chivers, LM Cambridge, N Holden, DM Slater, KJ Staples, ... FEBS letters 547 (1-3), 75-79, 2003 | 133 | 2003 |
Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients P Vijayanand, K Durkin, G Hartmann, J Morjaria, G Seumois, KJ Staples, ... The Journal of Immunology 184 (8), 4568-4574, 2010 | 118 | 2010 |
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD K Ostridge, N Williams, V Kim, M Bennett, S Harden, L Welch, S Bourne, ... Thorax 71 (2), 126-132, 2016 | 106 | 2016 |
Multitissue transcriptomics delineates the diversity of airway T cell functions in asthma A Singhania, JC Wallington, CG Smith, D Horowitz, KJ Staples, ... American journal of respiratory cell and molecular biology 58 (2), 261-270, 2018 | 101 | 2018 |
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations JA Tree, JE Turnbull, KR Buttigieg, MJ Elmore, N Coombes, J Hogwood, ... British Journal of Pharmacology 178 (3), 626-635, 2021 | 100 | 2021 |
Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care records NP Williams, NA Coombs, MJ Johnson, LK Josephs, LA Rigge, ... International journal of chronic obstructive pulmonary disease 12, 313, 2017 | 98 | 2017 |
Steroid-induced deficiency of mucosal-associated invariant T cells in the chronic obstructive pulmonary disease lung. Implications for nontypeable Haemophilus influenzae infection TSC Hinks, JC Wallington, AP Williams, R Djukanović, KJ Staples, ... American journal of respiratory and critical care medicine 194 (10), 1208-1218, 2016 | 97 | 2016 |
Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort VL Kim, NA Coombs, KJ Staples, KK Ostridge, NP Williams, SA Wootton, ... European Respiratory Journal 50 (4), 2017 | 90 | 2017 |
Adenosine 3′, 5′-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A KJ Staples, M Bergmann, K Tomita, MD Houslay, I McPhee, PJ Barnes, ... The Journal of Immunology 167 (4), 2074-2080, 2001 | 89 | 2001 |
Inflammatory phenotyping predicts clinical outcome in COVID-19 H Burke, A Freeman, DC Cellura, BL Stuart, NJ Brendish, S Poole, ... Respiratory Research 21 (1), 1-9, 2020 | 82 | 2020 |
Human CD49a+ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus GE Cooper, K Ostridge, SI Khakoo, TMA Wilkinson, KJ Staples Frontiers in Immunology 9, 1671, 2018 | 73 | 2018 |
IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection JC Wallington, AP Williams, KJ Staples, TMA Wilkinson Journal of Allergy and Clinical Immunology 141 (6), 2182-2195. e6, 2018 | 69 | 2018 |