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Senthilvelrajan Kaniyappan
Senthilvelrajan Kaniyappan
Lab head/Group leader at Neural Signalling section at Roche
在 roche.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
106842021
The release and trans-synaptic transmission of Tau via exosomes
Y Wang, V Balaji, S Kaniyappan, L Krüger, S Irsen, K Tepper, ...
Molecular neurodegeneration 12, 1-25, 2017
6342017
Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity
S Kumar, K Tepper, S Kaniyappan, J Biernat, S Wegmann, ...
Journal of biological chemistry 289 (29), 20318-20332, 2014
902014
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability
S Kaniyappan, RR Chandupatla, EM Mandelkow, E Mandelkow
Alzheimer's & Dementia 13 (11), 1270-1291, 2017
832017
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
S Kaniyappan, K Tepper, J Biernat, RR Chandupatla, S Hübschmann, ...
Molecular Neurodegeneration 15 (1), 39, 2020
492020
A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
F Drepper, J Biernat, S Kaniyappan, HE Meyer, EM Mandelkow, ...
Journal of Biological Chemistry 295 (52), 18213-18225, 2020
422020
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
J Hochmair, C Exner, M Franck, A Dominguez‐Baquero, L Diez, ...
The EMBO Journal 41 (11), e108882, 2022
402022
C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells.
RV Sasi Kumar K, Ramadhas A, Nayak SC, Kaniyappan S, Dayma K
Biochim Biophys Acta., 2015
38*2015
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems
V Balaji, S Kaniyappan, E Mandelkow, Y Wang, EM Mandelkow
Autophagy 14 (12), 2139-2154, 2018
332018
Potent Tau aggregation inhibitor D‐peptides selected against Tau‐repeat 2 using mirror image phage display
M Malhis, S Kaniyappan, I Aillaud, RR Chandupatla, LM Ramirez, ...
ChemBioChem 22 (21), 3049-3059, 2021
222021
Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes
RR Chandupatla, A Flatley, R Feederle, EM Mandelkow, S Kaniyappan
Alzheimer's & Dementia: Translational Research & Clinical Interventions 6 (1 …, 2020
212020
Suppressing tau aggregation and toxicity by an anti-aggregant tau fragment
GJ Pir, B Choudhary, S Kaniyappan, RR Chandupatla, E Mandelkow, ...
Molecular neurobiology 56, 3751-3767, 2019
172019
The plasma factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex
S Singh, A Nazabal, S Kaniyappan, JL Pellequer, AS Wolberg, D Imhof, ...
Biomolecules 9 (12), 765, 2019
162019
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
I Aillaud, S Kaniyappan, RR Chandupatla, LM Ramirez, S Alkhashrom, ...
Alzheimer's Research & Therapy 14 (1), 15, 2022
132022
Disruption of structural disulfides of coagulation FXIII-B subunit; functional implications for a rare bleeding disorder
S Singh, MS Akhter, J Dodt, A Sharma, S Kaniyappan, H Yadegari, ...
International Journal of Molecular Sciences 20 (8), 1956, 2019
82019
Spreading of tau protein does not depend on aggregation propensity
S Rodrigues, M Anglada-Huguet, K Hochgräfe, S Kaniyappan, ...
Journal of Molecular Neuroscience 73 (9), 693-712, 2023
42023
Purification and characterization of low-n tau oligomers
S Kaniyappan, RR Chandupatla, E Mandelkow
Amyloid Proteins: Methods and Protocols, 99-111, 2018
32018
Reversal of tau-dependent cognitive decay by blocking adenosine A1 receptors: comparison of transgenic mouse models with different levels of tauopathy
M Anglada-Huguet, H Endepols, A Sydow, R Hilgers, B Neumaier, ...
International journal of molecular sciences 24 (11), 9260, 2023
22023
Discovery of Orally Available and Brain Penetrant AEP Inhibitors
D Krummenacher, W He, B Kuhn, C Schnider, A Beurier, V Brom, ...
Journal of Medicinal Chemistry 66 (24), 17026-17043, 2023
12023
Pre-stress of actin cortices is important for the viscoelastic response of living cells
A Cordes, H Witt, A Gallemí-Pérez, B Brückner, F Grimm, M Vache, ...
BioRxiv, 783613, 2019
12019
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