| Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling L Gasparini, GK Gouras, R Wang, RS Gross, MF Beal, P Greengard, H Xu Journal of Neuroscience 21 (8), 2561-2570, 2001 | 642 | 2001 |
| Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription Y Chen, K Zhou, R Wang, Y Liu, YD Kwak, T Ma, RC Thompson, Y Zhao, ... Proceedings of the National Academy of Sciences 106 (10), 3907-3912, 2009 | 473 | 2009 |
| Does insulin dysfunction play a role in Alzheimer's disease? L Gasparini, WJ Netzer, P Greengard, H Xu Trends in pharmacological sciences 23 (6), 288-293, 2002 | 444 | 2002 |
| Potential roles of insulin and IGF-1 in Alzheimer's disease L Gasparini, H Xu Trends in neurosciences 26 (8), 404-406, 2003 | 362 | 2003 |
| Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action L Gasparini, E Ongini, G Wenk Journal of neurochemistry 91 (3), 521-536, 2004 | 309 | 2004 |
| Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ EVIDENCE FOR DISTINCT MECHANISMS INVOLVED IN γ-SECRETASE PROCESSING OF THE APP … C Yu, SH Kim, T Ikeuchi, H Xu, L Gasparini, R Wang, SS Sisodia Journal of Biological Chemistry 276 (47), 43756-43760, 2001 | 281 | 2001 |
| Interaction of tau protein with the dynactin complex E Magnani, J Fan, L Gasparini, M Golding, M Williams, G Schiavo, ... The EMBO journal 26 (21), 4546-4554, 2007 | 225 | 2007 |
| Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome A Contestabile, F Benfenati, L Gasparini Progress in neurobiology 91 (1), 1-22, 2010 | 217 | 2010 |
| Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease L Gasparini, M Racchi, G Binetti, M Trabucchi, SB Solerte, D Alkon, ... The FASEB journal 12 (1), 17-34, 1998 | 200 | 1998 |
| Lithium rescues synaptic plasticity and memory in Down syndrome mice A Contestabile, B Greco, D Ghezzi, V Tucci, F Benfenati, L Gasparini The Journal of Clinical Investigation 123 (1), 348, 2013 | 183 | 2013 |
| A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD) E Giorgio, D Robyr, M Spielmann, E Ferrero, E Di Gregorio, D Imperiale, ... Human molecular genetics 24 (11), 3143-3154, 2015 | 164 | 2015 |
| Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features V Tucci, T Kleefstra, A Hardy, I Heise, S Maggi, MH Willemsen, H Hilton, ... The Journal of clinical investigation 124 (4), 1468, 2014 | 160 | 2014 |
| Modulation of β‐amyloid metabolism by non‐steroidal anti‐inflammatory drugs in neuronal cell cultures L Gasparini, L Rusconi, H Xu, P Del Soldato, E Ongini Journal of neurochemistry 88 (2), 337-348, 2004 | 145 | 2004 |
| Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability L Gasparini, RA Crowther, KR Martin, N Berg, M Coleman, M Goedert, ... Neurobiology of aging 32 (3), 419-433, 2011 | 130 | 2011 |
| Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy E Barini, O Antico, Y Zhao, F Asta, V Tucci, T Catelani, R Marotta, H Xu, ... Molecular neurodegeneration 11, 1-20, 2016 | 116 | 2016 |
| Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells L Gasparini, M Racchi, L Benussi, D Curti, G Binetti, A Bianchetti, ... Neuroscience letters 231 (2), 113-117, 1997 | 110 | 1997 |
| A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface JY Leem, CA Saura, C Pietrzik, J Christianson, C Wanamaker, LST King, ... Neurobiology of disease 11 (1), 64-82, 2002 | 99 | 2002 |
| Attenuation of chronic neuroinflammation by a nitric oxide‐releasing derivative of the antioxidant ferulic acid GL Wenk, K McGann‐Gramling, B Hauss‐Wegrzyniak, D Ronchetti, ... Journal of neurochemistry 89 (2), 484-493, 2004 | 98 | 2004 |
| Early behavioural markers of disease in P301S tau transgenic mice ML Scattoni, L Gasparini, E Alleva, M Goedert, G Calamandrei, ... Behavioural brain research 208 (1), 250-257, 2010 | 97 | 2010 |
| Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease L Gasparini, E Ongini, D Wilcock, D Morgan Brain research reviews 48 (2), 400-408, 2005 | 96 | 2005 |
