Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers M Miteva, KC Kirkbride, KV Kilchrist, TA Werfel, H Li, CE Nelson, ... Biomaterials 38, 97-107, 2015 | 159 | 2015 |
Endosomolytic and tumor-penetrating mesoporous silica nanoparticles for siRNA/miRNA combination cancer therapy Y Wang, Y Xie, KV Kilchrist, J Li, CL Duvall, D Oupický ACS applied materials & interfaces 12 (4), 4308-4322, 2020 | 125 | 2020 |
Zwitterionic nanocarrier surface chemistry improves siRNA tumor delivery and silencing activity relative to polyethylene glycol MA Jackson, TA Werfel, EJ Curvino, F Yu, TE Kavanaugh, SM Sarett, ... ACS nano 11 (6), 5680-5696, 2017 | 117 | 2017 |
Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing SM Sarett, TA Werfel, L Lee, MA Jackson, KV Kilchrist, D Brantley-Sieders, ... Proceedings of the National Academy of Sciences 114 (32), E6490-E6497, 2017 | 116 | 2017 |
Gal8 visualization of endosome disruption predicts carrier-mediated biologic drug intracellular bioavailability KV Kilchrist, SC Dimobi, MA Jackson, BC Evans, TA Werfel, EA Dailing, ... ACS nano 13 (2), 1136-1152, 2019 | 115 | 2019 |
Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival TA Werfel, S Wang, MA Jackson, TE Kavanaugh, MM Joly, LH Lee, ... Cancer research 78 (7), 1845-1858, 2018 | 77 | 2018 |
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles BC Evans, RB Fletcher, KV Kilchrist, EA Dailing, AJ Mukalel, JM Colazo, ... Nature Communications 10 (1), 5012, 2019 | 66 | 2019 |
Porous silicon and polymer nanocomposites for delivery of peptide nucleic acids as anti-microRNA therapies KR Beavers, TA Werfel, T Shen, TE Kavanaugh, KV Kilchrist, JW Mares, ... Advanced Materials (Deerfield Beach, Fla.) 28 (36), 7984, 2016 | 56 | 2016 |
Endosomolytic nano-polyplex platform technology for cytosolic peptide delivery to inhibit pathological vasoconstriction BC Evans, KM Hocking, KV Kilchrist, ES Wise, CM Brophy, CL Duvall ACS nano 9 (6), 5893-5907, 2015 | 54 | 2015 |
MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia BC Evans, KM Hocking, MJ Osgood, I Voskresensky, J Dmowska, ... Science translational medicine 7 (291), 291ra95-291ra95, 2015 | 52 | 2015 |
Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy. ACS Appl. Mater Y Wang, Y Xie, KV Kilchrist, J Li, CL Duvall, DE Oupický Interfaces 12, 4308-4322, 2020 | 42 | 2020 |
Mechanism of enhanced cellular uptake and cytosolic retention of MK2 inhibitory peptide nano-polyplexes KV Kilchrist, BC Evans, CM Brophy, CL Duvall Cellular and molecular bioengineering 9, 368-381, 2016 | 37 | 2016 |
Conjugation of palmitic acid improves potency and longevity of siRNA delivered via endosomolytic polymer nanoparticles SM Sarett, KV Kilchrist, M Miteva, CL Duvall Journal of Biomedical Materials Research Part A 103 (9), 3107-3116, 2015 | 34 | 2015 |
Thiol‐acrylate nanocomposite foams for critical size bone defect repair: A novel biomaterial L Garber, C Chen, KV Kilchrist, C Bounds, JA Pojman, D Hayes Journal of Biomedical Materials Research Part A: An Official Journal of The …, 2013 | 32 | 2013 |
Amphiphilic polyelectrolyte graft copolymers enhance the activity of cyclic dinucleotide STING agonists DC Nguyen, D Shae, HM Pagendarm, KW Becker, M Wehbe, KV Kilchrist, ... Advanced healthcare materials 10 (2), 2001056, 2021 | 17 | 2021 |
Genetically encoded split-luciferase biosensors to measure endosome disruption rapidly in live cells KV Kilchrist, JW Tierney, CL Duvall ACS sensors 5 (7), 1929-1936, 2020 | 17 | 2020 |
Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis NA Mignemi, PM McClatchey, KV Kilchrist, IM Williams, BA Millis, ... American Journal of Physiology-Endocrinology and Metabolism 316 (6), E1012-E1023, 2019 | 14 | 2019 |
Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes AJ Mukalel, BC Evans, KV Kilchrist, EA Dailing, B Burdette, ... Journal of Controlled Release 282, 110-119, 2018 | 14 | 2018 |
Hydrolytic charge‐reversal of PEG ylated polyplexes enhances intracellular un‐packaging and activity of si RNA TA Werfel, C Swain, CE Nelson, KV Kilchrist, BC Evans, M Miteva, ... Journal of Biomedical Materials Research Part A 104 (4), 917-927, 2016 | 14 | 2016 |
Microparticle depots for controlled and sustained release of endosomolytic nanoparticles KM Garland, S Sevimli, KV Kilchrist, CL Duvall, RS Cook, JT Wilson Cellular and Molecular Bioengineering 12, 429-442, 2019 | 13 | 2019 |