| A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors EM Jarho, JI Venäläinen, J Huuskonen, JAM Christiaans, ... Journal of medicinal chemistry 47 (23), 5605-5607, 2004 | 82 | 2004 |
| Cardiovascular hybrid drugs: combination of more than one pharmacological property in one single molecule JAM Christiaans, H Timmerman European journal of pharmaceutical sciences 4 (1), 1-22, 1996 | 76 | 1996 |
| Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors JI Venäläinen, JA Garcia-Horsman, MM Forsberg, A Jalkanen, ... Biochemical pharmacology 71 (5), 683-692, 2006 | 73 | 2006 |
| 4-Phenylbutanoyl-2 (S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2 (S)-acylpyrrolidines as prolyl oligopeptidase inhibitors EAA Wallén, JAM Christiaans, SM Saario, MM Forsberg, JI Venäläinen, ... Bioorganic & medicinal chemistry 10 (7), 2199-2206, 2002 | 61 | 2002 |
| Dicarboxylic acid bis (L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors EAA Wallén, JAM Christiaans, MM Forsberg, JI Venäläinen, PT Männistö, ... Journal of medicinal chemistry 45 (20), 4581-4584, 2002 | 53 | 2002 |
| Synthesis and in Vitro Pharmacology of a Series of New Chiral Histamine H3-Receptor Ligands: 2-(R and S)-Amino-3-(1 H-imidazol-4 (5)-yl) propyl Ether Derivatives JT Kovalainen, JAM Christiaans, S Kotisaari, JT Laitinen, PT Männistö, ... Journal of medicinal chemistry 42 (7), 1193-1202, 1999 | 40 | 1999 |
| New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis (l-prolyl-pyrrolidine) amides EAA Wallén, JAM Christiaans, EM Jarho, MM Forsberg, JI Venäläinen, ... Journal of medicinal chemistry 46 (21), 4543-4551, 2003 | 35 | 2003 |
| Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site JI Venäläinen, RO Juvonen, JA Garcia-Horsman, EAA WALLéN, ... Biochemical Journal 382 (3), 1003-1008, 2004 | 32 | 2004 |
| Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors EAA Wallén, JAM Christiaans, TJ Saarinen, EM Jarho, MM Forsberg, ... Bioorganic & medicinal chemistry 11 (17), 3611-3619, 2003 | 31 | 2003 |
| Dicarboxylic Acid Azacycle l-Prolyl-pyrrolidine Amides as Prolyl Oligopeptidase Inhibitors and Three-Dimensional Quantitative Structure−Activity Relationship of the … EM Jarho, EAA Wallén, JAM Christiaans, MM Forsberg, JI Venäläinen, ... Journal of medicinal chemistry 48 (15), 4772-4782, 2005 | 24 | 2005 |
| Preclinical evaluation of [18F] PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors SSV Golla, PJ Klein, J Bakker, RC Schuit, JAM Christiaans, L van Geest, ... Nuclear medicine and biology 42 (2), 205-212, 2015 | 21 | 2015 |
| Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as … PJ Klein, JAM Christiaans, A Metaxas, RC Schuit, AA Lammertsma, ... Bioorganic & Medicinal Chemistry 23 (5), 1189-1206, 2015 | 20 | 2015 |
| 2 (S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl) pyrrolidines and 2 (S)-(aroyl)-1-(4-phenylbutanoyl) pyrrolidines as prolyl oligopeptidase inhibitors EM Jarho, JI Venäläinen, S Poutiainen, H Leskinen, J Vepsäläinen, ... Bioorganic & medicinal chemistry 15 (5), 2024-2031, 2007 | 20 | 2007 |
| Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate … PJ Klein, M Chomet, A Metaxas, JAM Christiaans, E Kooijman, RC Schuit, ... European journal of medicinal chemistry 118, 143-160, 2016 | 17 | 2016 |
| Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11C] methoxyphenyl) pyridin-3-yl) methyl) cyclopentanamine as a PET tracer for NR2B subunit … JAM Christiaans, PJ Klein, A Metaxas, EJM Kooijman, RC Schuit, ... Nuclear medicine and biology 41 (8), 670-680, 2014 | 16 | 2014 |
| A proton relay process as the mechanism of activation of the histamine H3-receptor determined by 1H NMR and ab initio quantum mechanical calculations JT Kovalainen, JAM Christiaans, R Ropponen, A Poso, M Peräkylä, ... Journal of the American Chemical Society 122 (29), 6989-6996, 2000 | 13 | 2000 |
| An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors EM Jarho, JI Venäläinen, J Juntunen, AL Yli-Kokko, J Vepsäläinen, ... Bioorganic & medicinal chemistry letters 16 (21), 5590-5593, 2006 | 12 | 2006 |
| Synthesis and in vitro pharmacology of new 1, 4-dihydropyridines. 1. 2-(ω-Aminoalkylthiomethyl)-1, 4-dihydropyridines as potent calcium channel blockers JAM Christiaans, AD Windhorst, PM Groenenberg, H Van der Goot, ... European journal of medicinal chemistry 28 (11), 859-867, 1993 | 12 | 1993 |
| Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates J van der Aart, M Yaqub, EJM Kooijman, J Bakker, JAM Langermans, ... Molecular Imaging and Biology 21, 676-685, 2019 | 11 | 2019 |
| 1H NMR study on putative intramolecular hydrogen bonding for histamine H3-receptor agonists JT Kovalainen, JAM Christiaans, A Poso, J Vepsäläinen, R Laatikainen, ... Tetrahedron letters 40 (12), 2425-2428, 1999 | 11 | 1999 |
