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Tim Majarian
Tim Majarian
Research Scientist, Vertex Pharmaceuticals
在 vrtx.com 的电子邮件经过验证
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Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers
KE Westerman, TD Majarian, F Giulianini, DK Jang, J Miao, JC Florez, ...
Nature Communications 13 (1), 3993, 2022
312022
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
H Kim, KE Westerman, K Smith, J Chiou, JB Cole, T Majarian, ...
Diabetologia 66 (3), 495-507, 2023
272023
Gene-lifestyle interactions in the genomics of human complex traits
V Laville, T Majarian, YJ Sung, K Schwander, MF Feitosa, DI Chasman, ...
European Journal of Human Genetics 30 (6), 730-739, 2022
212022
Point process models for localization and interdependence of punctate cellular structures
Y Li, TD Majarian, AW Naik, GR Johnson, RF Murphy
Cytometry Part A 89 (7), 633-643, 2016
142016
Rare non-coding variation identified by large scale whole genome sequencing reveals unexplained heritability of type 2 diabetes
J Wessel, TD Majarian, HM Highland, S Raghavan, MD Szeto, ...
MedRxiv, 2020.11. 13.20221812, 2020
132020
Learning the sequence of influenza A genome assembly during viral replication using point process models and fluorescence in situ hybridization
TD Majarian, RF Murphy, SS Lakdawala
Plos Computational Biology 15 (1), e1006199, 2019
132019
Association and interaction of genetics and area-level socioeconomic factors on the prevalence of type 2 diabetes and obesity
SJ Cromer, CM Lakhani, JM Mercader, TD Majarian, P Schroeder, ...
Diabetes Care 46 (5), 944-952, 2023
102023
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
D DiCorpo, SM Gaynor, EM Russell, KE Westerman, LM Raffield, ...
Communications biology 5 (1), 756, 2022
82022
Multi-ancestry polygenic mechanisms of type 2 diabetes
K Smith, AJ Deutsch, C McGrail, H Kim, S Hsu, A Huerta-Chagoya, ...
Nature medicine 30 (4), 1065-1074, 2024
62024
Cellorganizer: Learning and using cell geometries for spatial cell simulations
TD Majarian, I Cao-Berg, X Ruan, RF Murphy
Modeling Biomolecular Site Dynamics: Methods and Protocols, 251-264, 2019
62019
Deriving stratified effects from joint models investigating gene-environment interactions
V Laville, T Majarian, PS De Vries, AR Bentley, MF Feitosa, YJ Sung, ...
BMC bioinformatics 21, 1-11, 2020
52020
Specificity of CRISPR-Cas9 editing in exagamglogene autotemcel
A Yen, Z Zappala, RS Fine, TD Majarian, P Sripakdeevong, D Altshuler
New England Journal of Medicine 390 (18), 1723-1725, 2024
32024
Polygenic scores help reduce racial disparities in predictive accuracy of automated type 1 diabetes classification algorithms
AJ Deutsch, L Stalbow, TD Majarian, JM Mercader, AK Manning, ...
Diabetes care 46 (4), 794-800, 2023
32023
Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure
V Laville, T Majarian, YJ Sung, K Schwander, MF Feitosa, D Chasman, ...
bioRxiv, 562157, 2019
3*2019
A method for characterizing phenotypic changes in highly variable cell populations and its application to high content screening of Arabidopsis thaliana protoplasts
GR Johnson, JD Kangas, A Dovzhenko, R Trojok, K Voigt, TD Majarian, ...
Cytometry Part A 91 (4), 326-335, 2017
32017
Multi-ancestry polygenic mechanisms of type 2 diabetes elucidate disease processes and clinical heterogeneity
K Smith, AJ Deutsch, C McGrail, H Kim, S Hsu, R Mandla, PH Schroeder, ...
medRxiv, 2023
22023
Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption
TD Majarian, AR Bentley, V Laville, MR Brown, DI Chasman, PS de Vries, ...
Frontiers in Genetics 13, 954713, 2022
22022
Multi-omics insights into the biological mechanisms underlying gene-by-lifestyle interactions with smoking and alcohol consumption detected by genome-wide trans-ancestry meta …
TD Majarian, AR Bentley, V Laville, MR Brown, DI Chasman, LA Cupples, ...
medRxiv, 2021.07. 26.21261153, 2021
2021
Encouraging open science, replicability of analysis and collaborative cloud computing for whole genome sequence analysis of complex traits
T Majarian, AK Manning
GENETIC EPIDEMIOLOGY 42 (7), 715-715, 2018
2018
High-throughput Genetic Clustering of Type 2 Diabetes Loci Reveals Heterogeneous Mechanistic Pathways of Metabolic Disease
T Majarian, M von Grotthuss, JM Mercader, SH Kwak, J Kim, JC Florez, ...
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