| Cancer: a systems biology disease JJ Hornberg, FJ Bruggeman, HV Westerhoff, J Lankelma Biosystems 83 (2-3), 81-90, 2006 | 530 | 2006 |
| Control of MAPK signalling: from complexity to what really matters JJ Hornberg, B Binder, FJ Bruggeman, B Schoeberl, R Heinrich, ... Oncogene 24 (36), 5533-5542, 2005 | 251 | 2005 |
| Principles behind the multifarious control of signal transduction: ERK phosphorylation and kinase/phosphatase control JJ Hornberg, FJ Bruggeman, B Binder, CR Geest, AJMB De Vaate, ... The FEBS journal 272 (1), 244-258, 2005 | 242 | 2005 |
| Use of precision cut lung slices as a translational model for the study of lung biology G Liu, C Betts, DM Cunoosamy, PM Åberg, JJ Hornberg, KB Sivars, ... Respiratory research 20, 1-14, 2019 | 194 | 2019 |
| A high content screening assay to predict human drug-induced liver injury during drug discovery M Persson, AF Løye, T Mow, JJ Hornberg Journal of pharmacological and toxicological methods 68 (3), 302-313, 2013 | 123 | 2013 |
| Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how JJ Hornberg, M Laursen, N Brenden, M Persson, AV Thougaard, DB Toft, ... Drug discovery today 19 (8), 1131-1136, 2014 | 116 | 2014 |
| Metabolic control analysis to identify optimal drug targets JJ Hornberg, FJ Bruggeman, BM Bakker, HV Westerhoff Systems Biological Approaches in Infectious Diseases, 171-189, 2007 | 70 | 2007 |
| Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies JJ Hornberg, M Laursen, N Brenden, M Persson, AV Thougaard, DB Toft, ... Drug discovery today 19 (8), 1137-1144, 2014 | 62 | 2014 |
| A potential imprint control element: identification of a conserved 42 bp sequence upstream of H19 MAE Frevel, JJ Hornberg, AE Reeve Trends in Genetics 15 (6), 216-218, 1999 | 60 | 1999 |
| High‐content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity M Persson, AF Løye, M Jacquet, NS Mow, AV Thougaard, T Mow, ... Basic & clinical pharmacology & toxicology 115 (1), 18-23, 2014 | 57 | 2014 |
| Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma M Liljevald, M Rehnberg, M Söderberg, M Ramnegård, J Börjesson, ... Autoimmunity reviews 15 (11), 1062-1070, 2016 | 53 | 2016 |
| Characterization and optimization of a red-shifted fluorescence polarization ADP detection assay KM Kleman-Leyer, TA Klink, AL Kopp, TA Westermeyer, MD Koeff, ... Assay and drug development technologies 7 (1), 56-67, 2009 | 50 | 2009 |
| The NosX and NirX Proteins of Paracoccus denitrificans Are Functional Homologues: Their Role in Maturation of Nitrous Oxide Reductase NFW Saunders, JJ Hornberg, WNM Reijnders, HV Westerhoff, S de Vries, ... Journal of Bacteriology 182 (18), 5211-5217, 2000 | 46 | 2000 |
| Introduction to systems biology FJ Bruggeman, JJ Hornberg, FC Boogerd, HV Westerhoff Plant systems biology, 1-19, 2007 | 44 | 2007 |
| A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery AK Sjögren, K Breitholtz, E Ahlberg, L Milton, M Forsgard, M Persson, ... Archives of Toxicology 92, 3175-3190, 2018 | 40 | 2018 |
| Structure-based lead identification of ATP-competitive MK2 inhibitors T Barf, A Kaptein, S de Wilde, R van der Heijden, R van Someren, ... Bioorganic & medicinal chemistry letters 21 (12), 3818-3822, 2011 | 29 | 2011 |
| In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity JG Hengstler, AK Sjögren, D Zink, JJ Hornberg Archives of Toxicology 94, 353-356, 2020 | 27 | 2020 |
| Synergistic activation of signalling to extracellular signal‐regulated kinases 1 and 2 by epidermal growth factor and 4β‐phorbol 12‐myristate 13‐acetate JJ Hornberg, MR Tijssen, J Lankelma European journal of biochemistry 271 (19), 3905-3913, 2004 | 27 | 2004 |
| Advances in predictive toxicology for discovery safety through high content screening M Persson, JJ Hornberg Chemical Research in Toxicology 29 (12), 1998-2007, 2016 | 23 | 2016 |
| Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells AV Thougaard, J Christiansen, T Mow, JJ Hornberg Environmental and Molecular Mutagenesis 55 (9), 704-718, 2014 | 21 | 2014 |
