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Prof. Dr. Sevki Adem
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Identification of potent COVID-19 main protease (Mpro) inhibitors from natural polyphenols: an in silico strategy unveils a hope against CORONA
S Adem, V Eyupoglu, I Sarfraz, A Rasul, M Ali
Preprints 2020, 2020030333, 2020
2592020
Caffeic acid derivatives (CAFDs) as inhibitors of SARS-CoV-2: CAFDs-based functional foods as a potential alternative approach to combat COVID-19
Ş Adem, V Eyupoglu, I Sarfraz, A Rasul, AF Zahoor, M Ali, M Abdalla, ...
Phytomedicine 85, 153310, 2021
1222021
Synthesis, spectroscopic characterizations, enzyme inhibition, molecular docking study and DFT calculations of new Schiff bases of sulfa drugs
S Alyar, T Şen, ÜÖ Özmen, H Alyar, Ş Adem, C Şen
Journal of Molecular Structure 1185, 416-424, 2019
672019
Ginkgetin: A natural biflavone with versatile pharmacological activities
M Adnan, A Rasul, G Hussain, MA Shah, MK Zahoor, H Anwar, I Sarfraz, ...
Food and Chemical Toxicology 145, 111642, 2020
662020
Synthesis, spectroscopic characterizations, carbonic anhydrase II inhibitory activity, anticancer activity and docking studies of new Schiff bases of sulfa drugs
S Alyar, ÜÖ Özmen, Ş Adem, H Alyar, E Bilen, K Kaya
Journal of Molecular Structure 1223, 128911, 2021
532021
Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2′, 5′-ADP Sepharose 4B affinity in a …
S Adem, M Ciftci
Protein Expression and Purification 81 (1), 1-4, 2012
522012
Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
A Sarfraz, A Rasul, I Sarfraz, MA Shah, G Hussain, N Shafiq, M Masood, ...
Environmental Research 190, 110017, 2020
482020
Synthesis, characterization, antimicrobial activity, carbonic anhydrase enzyme inhibitor effects, and computational studies on new Schiff bases of Sulfa drugs and their Pd (II …
S Alyar, C Şen, H Alyar, Ş Adem, A Kalkanci, UO Ozdemir
Journal of Molecular Structure 1171, 214-222, 2018
482018
6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: from cancer initiation to metastasis and chemoresistance
I Sarfraz, A Rasul, G Hussain, MA Shah, FA Zahoor, M Asrar, Z Selamoglu, ...
BioFactors, 2020
452020
The isolation of secondary metabolites from Rheum ribes L. and the synthesis of new semi-synthetic anthraquinones: Isolation, synthesis and biological activity
IH Gecibesler, F Disli, S Bayindir, M Toprak, AR Tufekci, AS Yaglıoglu, ...
Food Chemistry 342, 128378, 2021
402021
In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2
E Aslan, C Guler, S Adem
Journal of enzyme inhibition and medicinal chemistry 31 (2), 314-317, 2016
392016
Investigation of the effects of some phenolic compounds on the Activities of glucose‐6‐phosphate dehydrogenase and 6‐Phosphogluconate dehydrogenase from human erythrocytes
S Adem, V Comakli, M Kuzu, R Demirdag
Journal of biochemical and molecular toxicology 28 (11), 510-514, 2014
372014
Physcion and physcion 8-O-β-D-glucopyranoside: natural anthraquinones with potential anticancer activities
M Adnan, A Rasul, G Hussain, MA Shah, I Sarfraz, B Nageen, A Riaz, ...
Current Drug Targets 22 (5), 488-504, 2021
322021
Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition …
S Adem, M Ciftci
Journal of enzyme inhibition and medicinal chemistry 31 (6), 1342-1348, 2016
322016
Synthesis, characterization, antimicrobial activity and carbonic anhydrase enzyme inhibitor effects of salicilaldehyde-N-methyl p-toluenesulfonylhydrazone and its Palladium (II …
S Alyar, Ş Adem
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 131, 294-302, 2014
282014
Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19
Ş Adem, V Eyupoglu, IM Ibrahim, I Sarfraz, A Rasul, M Ali, AA Elfiky
Computers in biology and medicine 145, 105452, 2022
252022
Germacrone: A potent secondary metabolite with therapeutic potential in metabolic diseases, cancer and viral infections
A Riaz, A Rasul, N Kanwal, G Hussain, MA Shah, I Sarfraz, R Ishfaq, ...
Current Drug Metabolism 21 (14), 1079-1090, 2020
252020
Synthesis, characterization, molecular docking and in vitro screening of new metal complexes with coumarin Schiff base as anticholine esterase and antipancreatic cholesterol …
Ö Şahin, Ü Özmen Özdemir, N Seferoğlu, Ş Adem, Z Seferoğlu
Journal of Biomolecular Structure and Dynamics 40 (10), 4460-4474, 2022
242022
In vitro effects of some flavones on human pyruvate kinase isoenzyme M2
E Aslan, S Adem
Journal of Biochemical and Molecular Toxicology 29 (3), 109-113, 2015
242015
Phytochemical composition, antioxidant, enzyme inhibition, antimicrobial effects, and molecular docking studies of Centaurea sivasica
Ü Yırtıcı, A Ergene, MN Atalar, Ş Adem
South African Journal of Botany 144, 58-71, 2022
232022
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