Biofilm formation mechanisms and targets for developing antibiofilm agents N Rabin, Y Zheng, C Opoku-Temeng, Y Du, E Bonsu, HO Sintim Future medicinal chemistry 7 (4), 493-512, 2015 | 826 | 2015 |
Agents that inhibit bacterial biofilm formation N Rabin, Y Zheng, C Opoku-Temeng, Y Du, E Bonsu, HO Sintim Future medicinal chemistry 7 (5), 647-671, 2015 | 319 | 2015 |
Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules C Opoku-Temeng, J Zhou, Y Zheng, J Su, HO Sintim Chemical Communications 52 (60), 9327-9342, 2016 | 103 | 2016 |
Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels M Wang, MA Sooreshjani, C Mikek, C Opoku-Temeng, HO Sintim Future Medicinal Chemistry 10 (11), 1301-1317, 2018 | 95 | 2018 |
Klebsiella pneumoniae capsule polysaccharide as a target for therapeutics and vaccines C Opoku-Temeng, SD Kobayashi, FR DeLeo Computational and structural biotechnology journal 17, 1360-1366, 2019 | 94 | 2019 |
Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative Y Zheng, G Tsuji, C Opoku-Temeng, HO Sintim Chemical science 7 (9), 6238-6244, 2016 | 56 | 2016 |
3H-pyrazolo [4, 3-f] quinoline haspin kinase inhibitors and anticancer properties C Opoku-Temeng, N Dayal, MA Sooreshjani, HO Sintim Bioorganic chemistry 78, 418-426, 2018 | 45 | 2018 |
N-(1, 3, 4-oxadiazol-2-yl) benzamide analogs, bacteriostatic agents against methicillin-and vancomycin-resistant bacteria C Opoku-Temeng, GA Naclerio, H Mohammad, N Dayal, NS Abutaleb, ... European Journal of Medicinal Chemistry 155, 797-805, 2018 | 42 | 2018 |
Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols C Opoku-Temeng, HO Sintim Scientific Reports 6 (1), 25445, 2016 | 39 | 2016 |
Targeting c-di-GMP signaling, biofilm formation, and bacterial motility with small molecules C Opoku-Temeng, HO Sintim c-di-GMP Signaling: Methods and Protocols, 419-430, 2017 | 38 | 2017 |
Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics C Opoku-Temeng, KI Onyedibe, UK Aryal, HO Sintim Journal of proteomics 202, 103368, 2019 | 36 | 2019 |
Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin C Opoku-Temeng, HO Sintim Chemical Communications 52 (19), 3754-3757, 2016 | 30 | 2016 |
Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis GA Naclerio, CW Karanja, C Opoku‐Temeng, HO Sintim ChemMedChem 14 (10), 1000-1004, 2019 | 29 | 2019 |
Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines N Dayal, C Opoku-Temeng, DE Hernandez, MA Sooreshjani, ... Future Medicinal Chemistry 10 (7), 823-835, 2018 | 25 | 2018 |
Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin C Opoku-Temeng, N Dayal, J Miller, HO Sintim RSC advances 7 (14), 8288-8294, 2017 | 24 | 2017 |
Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines E Larocque, N Naganna, X Ma, C Opoku-Temeng, B Carter-Cooper, ... Future medicinal chemistry 9 (11), 1213-1225, 2017 | 20 | 2017 |
Innate host defense against Klebsiella pneumoniae and the outlook for development of immunotherapies C Opoku-Temeng, N Malachowa, SD Kobayashi, FR DeLeo Journal of Innate Immunity 14 (3), 167-181, 2022 | 19 | 2022 |
Alkynylnicotinamide‐Based Compounds as ABL1 Inhibitors with Potent Activities against Drug‐Resistant CML Harboring ABL1 (T315I) Mutant Kinase EA Larocque, N Naganna, C Opoku‐Temeng, AM Lambrecht, HO Sintim ChemMedChem 13 (12), 1172-1180, 2018 | 17 | 2018 |
Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov–Doebner Reactions N Dayal, C Opoku-Temeng, H Mohammad, NS Abutaleb, D Hernandez, ... ACS infectious diseases 5 (11), 1820-1830, 2019 | 16 | 2019 |
Tetrahydro-3 H-pyrazolo [4, 3-a] phenanthridine-based CDK inhibitor C Opoku-Temeng, N Dayal, DE Hernandez, N Naganna, HO Sintim Chemical Communications 54 (36), 4521-4524, 2018 | 16 | 2018 |